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Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study
Conclusions Changes in non-HDL-C were significantly associated with subsequent risk of CVD events, and participants with a high-increasing pattern had a higher CVD risk. Long-term monitoring of non-HDL-C could be useful to improve the prediction of CVD risk. Trial registration number ChiCTR-TNC-1100148.
Source: BMJ Open - April 25, 2023 Category: General Medicine Authors: Ding, X., Zhou, H., Yue, Q., Shu, Z., Ma, X., Li, Y., Wu, S. Tags: Open access, Epidemiology Source Type: research

Prevalence of and factors associated with multimorbidity among 18 101 adults in the South East Asia Community Observatory Health and Demographic Surveillance System in Malaysia: a population-based, cross-sectional study of the MUTUAL consortium
Conclusions The current single-disease services in primary and secondary care should be accompanied by strategies to address complexities associated with multimorbidity, taking into account the factors associated with multimorbidity identified. Future research is needed to identify the most commonly occurring clusters of chronic diseases and their risk factors to develop more efficient and effective multimorbidity prevention and treatment strategies.
Source: BMJ Open - December 23, 2022 Category: General Medicine Authors: Tan, M. M. C., Prina, A. M., Muniz-Terrera, G., Mohan, D., Ismail, R., Assefa, E., Keinert, A. A. M., Kassim, Z., Allotey, P., Reidpath, D., Su, T. T. Tags: Open access, Epidemiology Source Type: research

Prevalence and factors associated with undiagnosed type 2 diabetes among adults in Iraq: analysis of cross-sectional data from the 2015 STEPS survey
Conclusion Almost one in ten adults in Iraq had UT2D, and various associated factors were identified that could be useful in planning interventions.
Source: BMJ Open - November 23, 2022 Category: General Medicine Authors: Pengpid, S., Peltzer, K. Tags: Open access, Global health Source Type: research

Chronic non-communicable diseases: Hainan prospective cohort study
Purpose The Hainan Cohort was established to investigate the incidence, morbidity and mortality of non-communicable diseases and their risk factors in the community population. Participants The baseline investigation of the Hainan Cohort study was initiated in five main areas of Hainan, China, from June 2018 to October 2020. A multistage cluster random-sampling method was used to obtain samples from the general population. Baseline assessments included a questionnaire survey, physical examination, blood and urine sample collection, and laboratory measurements, and outdoor environmental data were obtained. Findings to dat...
Source: BMJ Open - November 18, 2022 Category: General Medicine Authors: Gu, X., Lin, L., Zhao, C., Wu, L., Liu, Y., He, L., Lin, G., Lin, Y., Zhang, F. Tags: Open access, Public health Source Type: research

Prevalence and associated factors of anxiety among the population in an urban area of China: a cross-sectional study
Conclusions Our findings showed an alarmingly high prevalence of anxiety in the population living in an urban area of China. Sleep time <6 hours and waking up suffocating had a significant association with anxiety. These findings suggest that future anxiety prevention programmes in urban areas should incorporate interventions targeted at these factors, such as improving residents’ sleep quality.
Source: BMJ Open - November 8, 2022 Category: General Medicine Authors: Wang, Q., Zhang, J., Yao, H., Jin, P., Zhao, F., Zhang, P. Tags: Open access, Mental health Source Type: research

Reporting dose in complex self-management support interventions for long-term conditions: is it defined by researchers and received by participants? A systematic review
Conclusions Interpreting results and implementing effective complex self-management interventions is difficult when researchers’ reporting of dose is not in line with guidelines. If trial findings indicate benefit from the intervention, clear reporting of dose ensures reliable implementation to standard care. If the results are non-significant, detailed reporting enables better interpretation of results, that is, differentiating between poor implementation and lack of effectiveness. This ensures quality of interventions and validity and generalisability of trial findings. Therefore, wider adoption of reporting the TI...
Source: BMJ Open - August 17, 2022 Category: General Medicine Authors: Rookes, T. A., Barat, A., Turner, R., Taylor, S. Tags: Open access, Evidence based practice Source Type: research

Community-based culturally tailored education programmes for black adults with cardiovascular disease, diabetes, hypertension and stroke: a systematic review protocol of primary empirical studies
The objectives of this review are to: (1) synthesise key programme characteristics and outcomes of culturally tailored community-based (CBCT) programmes that are designed to improve health outcomes in black adults with cardiovascular disease, hypertension, diabetes, or stroke and (2) identify which of the five categories of culturally appropriate programmes from Kreuter and colleagues have been used to implement CBCT programmes. Methods and analysis This is a protocol for a systematic review that will search Medline, Embase and Cumulative Index to Nursing and Allied Health Literature databases to identify studies of CBCT ...
Source: BMJ Open - June 10, 2022 Category: General Medicine Authors: Fulton, J. I., Singh, H., Pakkal, O., Uleryk, E. M., Nelson, M. L. Tags: Open access, Health services research Source Type: research

Danish validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ) and findings from a population health survey: a mixed-methods study
Conclusion The Danish MTBQ is a valid measure of treatment burden with good construct validity and high internal reliability. This is the first study to explore treatment burden at a population level and provides important evidence to policy makers and clinicians about sociodemographic groups at risk of higher treatment burden.
Source: BMJ Open - January 3, 2022 Category: General Medicine Authors: Pedersen, M. H., Duncan, P., Lasgaard, M., Friis, K., Salisbury, C., Breinholt Larsen, F. Tags: Open access, Research methods Source Type: research

Hospital-diagnosed atopic dermatitis and long-term risk of myocardial infarction: a population-based follow-up study
Conclusions Hospital-diagnosed AD was associated with increased risk of MI compared with the general population.
Source: BMJ Open - November 10, 2016 Category: Journals (General) Authors: Riis, J. L., Vestergaard, C., Hjuler, K. F., Iversen, L., Jakobsen, L., Deleuran, M. S., Olsen, M. Tags: Open access, Cardiovascular medicine, Dermatology Research Source Type: research

Psychological factors and DNA methylation of genes related to immune/inflammatory system markers: the VA Normative Aging Study
Conclusions These findings suggest that positive and negative psychological factors affect DNA methylation of selected genes involved in chronic immune/inflammatory processes and inflammation-related endothelial dysfunction. Such epigenetic changes may represent biological pathways that mediate the effects of psychological factors on CHD.
Source: BMJ Open - January 5, 2016 Category: Journals (General) Authors: Kim, D., Kubzansky, L. D., Baccarelli, A., Sparrow, D., Spiro, A., Tarantini, L., Cantone, L., Vokonas, P., Schwartz, J. Tags: Open access, Epidemiology, Public health Research Source Type: research

Implementing guidelines to routinely prevent chronic vascular disease in primary care: the Preventive Evidence into Practice cluster randomised controlled trial
Conclusions This intervention was associated with improved recording of some risk factors but no change in the level of risk at the follow-up audit. Trial registration number Australian and New Zealand Clinical Trials Register (ANZCTR): ACTRN12612000578808, results.
Source: BMJ Open - December 11, 2015 Category: Journals (General) Authors: Harris, M. F., Parker, S. M., Litt, J., van Driel, M., Russell, G., Mazza, D., Jayasinghe, U. W., Del Mar, C., Lloyd, J., Smith, J., Zwar, N., Taylor, R., Powell Davies, G., On behalf of the Preventive Evidence into Practice (PEP) Partnership Group, On be Tags: Open access, Cardiovascular medicine, Evidence based practice, General practice / Family practice, Health services research, Public health, Diabetes and Endocrinology Source Type: research

Informed shared decision-making programme on the prevention of myocardial infarction in type 2 diabetes: a randomised controlled trial
Conclusions The ISDM-P on preventive measures in type 2 diabetes was effective under high fidelity conditions. Involvement of diabetes educators may facilitate implementation of the informed shared decision-making. Trial registration number ISRCTN84636255.
Source: BMJ Open - November 13, 2015 Category: Journals (General) Authors: Buhse, S., Mühlhauser, I., Heller, T., Kuniss, N., Müller, U. A., Kasper, J., Lehmann, T., Lenz, M. Tags: Open access, Evidence based practice, Medical education and training Research Source Type: research

Self-rated health and standard risk factors for myocardial infarction: a cohort study
Conclusions This study supports the use of self-rated health as a standard risk factor among others for myocardial infarction. It remains to demonstrate whether self-rated health adds predictive value for myocardial infarction in combined algorithms with standard risk factors.
Source: BMJ Open - February 13, 2015 Category: Journals (General) Authors: Waller, G., Janlert, U., Norberg, M., Lundqvist, R., Forssen, A. Tags: Open access, Cardiovascular medicine, Public health Research Source Type: research

Stroke incidence and association with risk factors in women: a 32-year follow-up of the Prospective Population Study of Women in Gothenburg
Conclusions Hypertension, smoking, AF, diabetes and high BMI were associated with increased stroke risk. Low education was associated with stroke. Validation of National Patient Registry diagnoses to increase specified diagnoses improved data quality.
Source: BMJ Open - October 28, 2014 Category: Journals (General) Authors: Blomstrand, A., Blomstrand, C., Ariai, N., Bengtsson, C., Bjorkelund, C. Tags: Open access, Cardiovascular medicine, Epidemiology Research Source Type: research