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Question 1: Role of methotrexate in severe atopic eczema in children
Scenario EW is a 10-year-old female with severe atopic eczema. She has had frequent flare-ups and multiple secondary infections since 6 months of age. Previous therapy has included prednisolone, aciclovir, flucloxacillin, topical fucibet, emollients and steroids. She currently requires high-dose steroids and symptoms recur when tapering the dose. EW's eczema has a severe impact on her quality of life: she has low self-esteem, struggles with sleep and is bullied at school. You wonder if methotrexate would reduce the severity of EW's eczema. Structured clinical question In children with severe eczema, does methotrexate ...
Source: Archives of Disease in Childhood - July 17, 2015 Category: Pediatrics Authors: Scott, M., Lakshman Tags: ADC Archimedes, Oncology, Immunology (including allergy), Vaccination / immunisation, Child health, Physiotherapy, Dermatology, Undergraduate Source Type: research

What Are Risk Factors for Progression To Severe Disease with Bronchiolitis?
Discussion Bronchiolitis is a clinical disease with following features: begins usually with rhinitis and cough that may progress to also having tachypnea, rales, wheezing and increased work of breathing shown by nasal flaring and/or accessory muscle use. The increased work of breathing may cause problems with feeding and hydration and also with mental status changes. It is usually seen in infants and children < 2 years of age. It is also usually seasonal (winter in upper North America) with 60-70% of cases being caused by respiratory syncytial virus but also human rhinorvirus, human metapneumovirus, influenza, adenoviru...
Source: PediatricEducation.org - December 15, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news