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Of mice and men – modeling post‐stroke depression experimentally
Summary At least one third of stroke survivors suffer from depression. The development of comorbid depression after stroke is clinically highly significant, because post‐stroke depression is associated with increased mortality, slows recovery and leads to worse functional outcomes. Here, we review the evidence that post‐stroke depression can be effectively modeled in experimental rodents via a variety of approaches. This opens an exciting new window onto the neurobiology of depression and permits probing potential underlying mechanisms such as disturbed cellular plasticity, neuroendocrine dysregulation, neuroinflammati...
Source: British Journal of Pharmacology - May 19, 2014 Category: Drugs & Pharmacology Authors: G Kronenberg, K Gertz, A Heinz, M Endres Tags: Review Article – Animal Models in Psychiatry Research Themed Issue Source Type: research

Of mice and men: modelling post‐stroke depression experimentally
At least one‐third of stroke survivors suffer from depression. The development of comorbid depression after stroke is clinically highly significant because post‐stroke depression is associated with increased mortality, slows recovery and leads to worse functional outcomes. Here, we review the evidence that post‐stroke depression can be effectively modelled in experimental rodents via a variety of approaches. This opens an exciting new window onto the neurobiology of depression and permits probing potential underlying mechanisms such as disturbed cellular plasticity, neuroendocrine dysregulation, neuroinflammation, an...
Source: British Journal of Pharmacology - July 2, 2014 Category: Drugs & Pharmacology Authors: G Kronenberg, K Gertz, A Heinz, M Endres Tags: REVIEW Source Type: research