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Dyslipidemia
Ann Intern Med. 2023 Jun 13. doi: 10.7326/AITC202306200. Online ahead of print.ABSTRACTDyslipidemia is an important risk factor for coronary artery disease and stroke. All persons with dyslipidemia should be advised to focus on lifestyle interventions, including regular aerobic exercise, a healthy diet, maintenance of a healthy weight, and abstinence from smoking. In addition to lifestyle interventions, lipid-lowering therapy should be considered for persons at moderate to high risk for atherosclerotic cardiovascular disease based on validated risk equations. Statin therapy is the first-line medical treatment for dyslipide...
Source: Annals of Internal Medicine - June 12, 2023 Category: Internal Medicine Authors: Marios Arvanitis Charles J Lowenstein Source Type: research

Cost-Effectiveness of Alirocumab: A Just-in-Time Analysis Based on the ODYSSEY Outcomes Trial.
Conclusion: The price of alirocumab would have to be reduced considerably to be cost-effective. Because substantial reductions already have occurred, we believe that timely, independent cost-effectiveness analyses can inform clinical and policy discussions of new drugs as they enter the market. Primary Funding Source: University of California, San Francisco, and Institute for Clinical and Economic Review. PMID: 30597485 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - January 1, 2019 Category: Internal Medicine Authors: Kazi DS, Penko J, Coxson PG, Guzman D, Wei PC, Bibbins-Domingo K Tags: Ann Intern Med Source Type: research

Clinical Implications of Revised Pooled Cohort Equations for Estimating Atherosclerotic Cardiovascular Disease Risk.
Conclusion: Revised PCEs can improve the accuracy of CVD risk estimates. Primary Funding Source: National Institutes of Health. PMID: 29868850 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - June 5, 2018 Category: Internal Medicine Authors: Yadlowsky S, Hayward RA, Sussman JB, McClelland RL, Min YI, Basu S Tags: Ann Intern Med Source Type: research

Trends in Racial/Ethnic and Nativity Disparities in Cardiovascular Health Among Adults Without Prevalent Cardiovascular Disease in the United States, 1988 to 2014.
Conclusion: Cardiovascular health has declined in the United States, racial/ethnic and nativity disparities persist, and decreased disparities seem to be due to worsening cardiovascular health among whites rather than gains among African Americans and Mexican Americans. Multifaceted interventions are needed to address declining population health and persistent health disparities. Primary Funding Source: National Institute of Neurological Disorders and Stroke and National Center for Advancing Translational Science of the National Institutes of Health. PMID: 29554692 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Brown AF, Liang LJ, Vassar SD, Escarce JJ, Merkin SS, Cheng E, Richards A, Seeman T, Longstreth WT Tags: Ann Intern Med Source Type: research

Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Conclusion: Evidence does not support use of the studied pharmacologic treatments for cognitive protection in persons with normal cognition or MCI. Primary Funding Source: Agency for Healthcare Research and Quality. PMID: 29255847 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - December 19, 2017 Category: Internal Medicine Authors: Fink HA, Jutkowitz E, McCarten JR, Hemmy LS, Butler M, Davila H, Ratner E, Calvert C, Barclay TR, Brasure M, Nelson VA, Kane RL Tags: Ann Intern Med Source Type: research

Continued Statin Prescriptions After Adverse Reactions and Patient Outcomes: A Cohort Study.
Conclusion: Continued statin prescriptions after an adverse reaction were associated with a lower incidence of death and cardiovascular events. Primary Funding Source: Chinese National Key Program of Clinical Science, National Natural Science Foundation of China, and Young Scientific Research Fund of Peking Union Medical College Hospital. PMID: 28738423 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - July 25, 2017 Category: Internal Medicine Authors: Zhang H, Plutzky J, Shubina M, Turchin A Tags: Ann Intern Med Source Type: research

Comparative effectiveness of generic and brand-name statins on patient outcomes: a cohort study.
CONCLUSION: Compared with those initiating brand-name statins, patients initiating generic statins were more likely to adhere and had a lower rate of a composite clinical outcome. PRIMARY FUNDING SOURCE: Teva Pharmaceuticals. PMID: 25222387 [PubMed - in process]
Source: Annals of Internal Medicine - September 16, 2014 Category: Internal Medicine Authors: Gagne JJ, Choudhry NK, Kesselheim AS, Polinski JM, Hutchins D, Matlin OS, Brennan TA, Avorn J, Shrank WH Tags: Ann Intern Med Source Type: research

Review: In older patients without CVD, statins reduce MI and stroke but not all-cause mortality.
PMID: 24842442 [PubMed - in process]
Source: Annals of Internal Medicine - May 20, 2014 Category: Internal Medicine Authors: Schaefer S Tags: Ann Intern Med Source Type: research

Screening, Monitoring, and Treatment of Stage 1 to 3 Chronic Kidney Disease: A Clinical Practice Guideline From the Clinical Guidelines Committee of the American College of Physicians.
Abstract DESCRIPTION: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the screening, monitoring, and treatment of adults with stage 1 to 3 chronic kidney disease. METHODS: This guideline is based on a systematic evidence review evaluating the published literature on this topic from 1985 through November 2011 that was identified by using MEDLINE and the Cochrane Database of Systematic Reviews. Searches were limited to English-language publications. The clinical outcomes evaluated for this guideline included all-cause mortality, c...
Source: Annals of Internal Medicine - October 22, 2013 Category: Internal Medicine Authors: Qaseem A, Hopkins RH, Sweet DE, Starkey M, Shekelle P Tags: Ann Intern Med Source Type: research