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Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through ...
Conclusion Combined treatment with sulindac and simvastatin augmented their apoptotic potential in lung cancer cells through AKT signaling-dependent downregulation of survivin. These results indicate that sulindac and simvastatin may be clinically promising therapies for the prevention of lung cancer.
Source: Cancer Research and Treatment - October 26, 2014 Category: Cancer & Oncology Tags: Original Article Source Type: research

Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis
Autophagy. 2021 Sep 15:1-19. doi: 10.1080/15548627.2021.1965421. Online ahead of print.ABSTRACTEpidemiological and clinical studies have shown that exposure to particulate matter (PM) is associated with an increased incidence of lung cancer and metastasis. However, the underlying mechanism remains unclear. Here, we demonstrated the central role of PM-induced neutrophil recruitment in promoting lung cancer metastasis. We found that reactive oxygen species (ROS)-mediated alveolar epithelial macroautophagy/autophagy was essential for initiating neutrophil chemotaxis and pre-metastatic niche formation in the lungs in response ...
Source: Autophagy - September 15, 2021 Category: Cytology Authors: Jiajun Liu Shumin Li Xuefeng Fei Xi Nan Yingying Shen Huiqing Xiu Stephania A Cormier Chaojie Lu Chuqi Guo Shibo Wang Zhijian Cai Pingli Wang Source Type: research