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Acute administration of metformin prior to cardiac ischemia/reperfusion injury protects brain injury.
Abstract Myocardial ischemia is the malperfusion of cardiac tissue due to a blockage in a coronary artery. Subsequent return of blood flow to the ischemic area of the heart, results in ischemia/reperfusion (I/R) injury in the heart and other organs, including the brain. Besides the cardioprotective effects of metformin on the heart against cardiac I/R injury, metformin also reduced neuronal injury in a stroke model. However, the effects of metformin on the brain following cardiac I/R injury has not yet been investigated. Therefore, we hypothesize that metformin reduces brain damage via decreasing brain mitochondri...
Source: European Journal of Pharmacology - July 31, 2020 Category: Drugs & Pharmacology Authors: Leech T, Apaijai N, Palee S, Higgins LA, Maneechote C, Chattipakorn N, Chattipakorn SC Tags: Eur J Pharmacol Source Type: research

D-serine metabolism in the medial prefrontal cortex, but not the hippocampus, is involved in AD/HD-like behaviors in SHRSP/Ezo
Eur J Pharmacol. 2022 Mar 29:174930. doi: 10.1016/j.ejphar.2022.174930. Online ahead of print.ABSTRACTAttention-deficit/hyperactivity disorder (AD/HD) is a mild neurodevelopmental disorder with inattention, hyperactivity, and impulsivity as its core symptoms. We previously revealed that an AD/HD animal model, juvenile stroke-prone spontaneously hypertensive rats (SHRSP/Ezo) exhibited functional abnormalities in N-methyl-D-aspartate (NMDA) receptors in the prefrontal cortex. D-serine is an endogenous co-ligand that acts on the glycine-binding site of NMDA receptors, which is essential for the physiological activation of NMD...
Source: European Journal of Pharmacology - April 1, 2022 Category: Drugs & Pharmacology Authors: Tsugumi Shindo Hiroki Shikanai Akane Watarai Sachiko Hiraide Kenji Iizuka Takeshi Izumi Source Type: research