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Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Condition: Heatstroke

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Total 16 results found since Jan 2013.

Increased cytokine and chemokine gene expression in the CNS of mice during heat stroke recovery.
Abstract Heat stroke (HS) is characterized by a systemic inflammatory response syndrome (SIRS) consisting of profound core temperature (Tc) changes in mice. Encephalopathy is common at HS collapse, but inflammatory changes occurring in the brain during the SIRS remain unidentified. We determined the association between inflammatory gene expression changes in the brain with Tc disturbances during HS recovery in mice. Gene expression changes of heat shock protein (HSP)72, heme-oxygenase (hmox1), cytokines (IL-1β, IL-6, TNFα), cyclooxygenase enzymes (COX-1, COX-2), chemokines (MCP-1, MIP-1α, MIP-1β, CX3CR1), and ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 11, 2013 Category: Physiology Authors: Biedenkapp JC, Leon LR Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Attenuated Thermoregulatory, Metabolic and Liver Acute Phase Protein Response to Heat Stroke in TNF Receptor Knockout Mice.
Abstract Tumor necrosis factor (TNF) is considered an adverse mediator of heat stroke (HS) based on clinical studies showing high serum levels. However, soluble TNF receptors (sTNFR; TNF antagonists) were higher in survivors than nonsurvivors and TNFR KO mice showed a trend towards increased mortality suggesting TNF has protective actions for recovery. We delineated TNF actions in HS by comparing thermoregulatory, metabolic and inflammatory responses between B6129F2 (WT) and TNFR KO mice. Prior to heat exposure, TNFR KO mice showed ~0.4°C lower core temperature (Tc; radiotelemetry), ~10% lower metabolic rate (Mr;...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 16, 2013 Category: Physiology Authors: Leon LR, Dineen SM, Blaha MD, Rodriguez-Fernandez M, Clarke DC Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Point-of-care cardiac troponin test accurately predicts heat stroke severity in rats.
Abstract Heat stroke (HS) remains a significant public health concern. Despite the substantial threat posed by HS, there is still no field or clinical test of HS severity. We suggested previously that circulating cardiac troponin (cTnI) could serve as a robust biomarker of HS severity after heating. In the current study, we hypothesized that cTnI band intensity on a portable point-of-care test (ctPOC) could be used to predict severity and organ damage at the onset of HS. Conscious male Fischer 344 rats (N=16) continuously monitored for HR, BP, and core temperature (Tc) (radiotelemetry) were heated to maximum Tc (T...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 19, 2015 Category: Physiology Authors: Audet GN, Quinn CM, Leon LR Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Neuromotor deficits and altered physiological responses to repeated exertional heat stroke exposures in mice
In conclusion, exposure to a second EHS after two weeks, leads to increased exercise times in the heat, symptom limitation at a lower Tc,max, and greater deficits in neuromotor and behavioral function during recovery.PMID:36279505 | DOI:10.1152/ajpregu.00152.2022
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 24, 2022 Category: Physiology Authors: Jamal M Alzahrani Kevin O Murray Bryce J Gambino Christian K Garcia Laila H Sheikh Kevin J Cusack Orlando Laitano Thomas L Clanton Source Type: research

Identification of therapeutic targets in a murine model of severe exertional heat stroke
Am J Physiol Regul Integr Comp Physiol. 2022 Oct 25. doi: 10.1152/ajpregu.00150.2022. Online ahead of print.ABSTRACTExertional heat stroke (EHS) is a potentially lethal condition resulting from high core body temperatures (TC) in combination with a systemic inflammatory response syndrome (SIRS) with varying degrees of severity across victims, and limited understanding of the underlying mechanism(s). We established a mouse model of severe EHS in an effort to identify mechanisms of hyperthermia / inflammation that may be responsible for organ damage. Mice were forced to run on a motorized wheel in a 37.5°C chamber until los...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 25, 2022 Category: Physiology Authors: Kentaro Oki Chloe G Henderson Shauna M Ward Jermaine A Ward Mark L Plamper Thomas A Mayer Aaron R Caldwell Lisa R Leon Source Type: research

Body mass index, but not sex, influences exertional heat stroke risk in young healthy men and women
Am J Physiol Regul Integr Comp Physiol. 2022 Nov 7. doi: 10.1152/ajpregu.00168.2022. Online ahead of print.ABSTRACTExertional heat stroke (EHS) remains a persistent threat for individuals working or playing in the heat, including athletes, the military and emergency service personnel. However, influence of biological sex and/or body mass index (BMI) on the risk of EHS remain poorly understood. The purpose of this study was to retrospectively assess the influence of sex and BMI on risk of EHS in the active duty U.S. Army. We analyzed data from 2016-2021, using a matched case-control approach, where each individual with a di...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - November 7, 2022 Category: Physiology Authors: Gabrielle E W Giersch Kathryn M Taylor Aaron R Caldwell Nisha Charkoudian Source Type: research

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