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Prolongation of Life in Rats with Malignant Glioma by Intranasal siRNA/Drug Codelivery to the Brain with Cell-Penetrating Peptide-Modified Micelles
Molecular PharmaceuticsDOI: 10.1021/mp400644e
Source: Molecular Pharmaceutics - April 16, 2014 Category: Drugs & Pharmacology Authors: Takanori Kanazawa, Kazuki Morisaki, Shohei Suzuki and Yuuki Takashima Source Type: research

Involvement of midkine in neuroblastoma tumourigenesis
This article is part of a themed section on Midkine. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐4
Source: British Journal of Pharmacology - January 24, 2014 Category: Drugs & Pharmacology Authors: S Kishida, K Kadomatsu Tags: REVIEW Source Type: research

Involvement of midkine in neuroblastoma tumorigenesis
Summary Midkine is highly expressed in various cancers, including neuroblastoma, one of the most malignant pediatric solid tumors, and it has been shown to be useful as a tumor marker, a prognosis factor, and a target of molecular therapy. In order to establish a midkine‐targetting therapy, several molecular tools (e.g., siRNA, antibodies, and RNA aptamer) have been used. In neuroblastoma, the involvement of midkine in tumorigenesis has been revealed in vivo by model mice, and its targetting by RNA aptamer has been shown to be effective toward xenografted tumors. Chemoresistance is one of the notable phenotypes regulated...
Source: British Journal of Pharmacology - October 7, 2013 Category: Drugs & Pharmacology Authors: S Kishida, K Kadomatsu Tags: Review Article – Midkine Themed Issue Source Type: research

Involvement of Src and the actin cytoskeleton in the antitumorigenic action of adenosine dialdehyde.
In this study, we examined the effects of transmethylation on tumorigenic responses and its regulatory mechanism using an upregulation strategy of adenosylhomocysteine (SAH) acting as a negative feedback inhibitor. Treatment with adenosine dialdehyde (AdOx), an inhibitor of transmethylation-suppressive adenosylhomocysteine (SAH) hydrolase (SAHH), enhanced the level of SAH and effectively blocked the proliferation, migration, and invasion of cancer cells; the treatment also induced the differentiation of C6 glioma cells and suppressed the neovascular genesis of eggs in a dose-dependent manner. Through immunoblotting analysi...
Source: Biochemical Pharmacology - January 24, 2013 Category: Drugs & Pharmacology Authors: Kim JH, Lee YG, Yoo S, Oh J, Jeong D, Song WK, Yoo BC, Rhee MH, Park J, Cha SH, Hong S, Cho JY Tags: Biochem Pharmacol Source Type: research

Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
In this study, we found that inhibition of T-type Ca(2+) channels in GBM cells significantly reduced their survival and resistance to therapy. Moreover, either T-type selective antagonists, such as mibefradil, or siRNA-mediated knockdown of the T-type channel alpha subunits not only reduced cell viability and clonogenic potential, but also induced apoptosis. In response to channel blockade or ablation, we observed reduced phosphorylation of Akt and Rictor, suggesting inhibition of the mTORC2/Akt pathway. This was followed by reduction in phosphorylation of anti-apoptotic Bad and caspases activation. The apoptotic response ...
Source: Biochemical Pharmacology - December 31, 2012 Category: Drugs & Pharmacology Authors: Valerie NC, Dziegielewska B, Hosing AS, Augustin E, Gray LS, Brautigan DL, Larner JM, Dziegielewski J Tags: Biochem Pharmacol Source Type: research

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