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Abstract PD4-07: Are aromatase inhibitors associated with higher myocardial infarction risk in breast cancer patients? A Medicare population study
Conclusions: The occurrence of MI is very low in this cohort (4.4%), reassuring the clinicians that the older adults with comorbidities may not be at a higher risk of MI with adjuvant endocrine therapy. However, the confidence interval for the hazard ratio of AIs vs Tamoxifen is very wide, indicating that a larger sample may be needed for the power of the study to be conclusive.Citation Format: Kamaraju S, Smith E, Shi Y, Laud P, Neuner J. Are aromatase inhibitors associated with higher myocardial infarction risk in breast cancer patients? A Medicare population study [abstract]. In: Proceedings of the Thirty-Ninth Annual C...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: S Kamaraju, E Smith, Y Shi, P Laud, J Neuner Tags: Poster Discussion Abstracts Source Type: research

Abstract P2-01-23: Long-term follow-up of persistent breast dermopigmentation after sentinel lymph node identification using superparamagnetic iron oxide particles (SIENNA+(R))
Patients with breast cancer (BC) and those at high risk for BC are often reluctant to initiate Tamoxifen (Tam) due to potential adverse events (AEs) such as deep vein thrombosis (DVT), pulmonary embolus (PE), acute ischemic stroke (AIS), myocardial infarction (MI) and endometrial cancer (EC). Some decline this life saving therapy due to fear of AEs. AE rates from RCTs are low, but AE rates in the general population are not well documented.Methods: The MarketScanR database (2010-2013) was searched for patients aged 30-64 with a prescription of Tam active for more than 120 days. Patients with prior DVT, PE, AIS, MI or EC wer...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: K Hannebicque, L Boulanger, E Bogart, S Giard, MP Chauvet, JL Houpeau Tags: Poster Session Abstracts Source Type: research

Abstract 882: Obesity, comorbidity and endometrial cancer survival: the multiethnic cohort
We examined the association of pre-diagnostic BMI and obesity-related comorbidities with overall survival in African-American, Japanese, Native Hawaiian, Latino and white women in the Multiethnic Cohort.Methods: Women with complete risk factor data who developed endometrial cancer during follow up were included in the analysis (N = 998). BMI and obesity-related comorbidities (diabetes, hypertension, heart attack and stroke) were self-reported at cohort entry and at subsequent follow-ups. Cox's models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) with time-varying exposures in relation to all...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Setiawan, V. W., Maskarinec, G., Lin, Y. G., Yang, D., Wilkens, L. R., Henderson, B. E., Le Marchand, L. Tags: Epidemiology Source Type: research