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Peroxisome proliferator‐activated receptors in cardiovascular diseases: experimental benefits and clinical challenges
This article reviews the cardiovascular effects of PPARs, with emphasis on the therapeutic potential of PPAR agonists in combating metabolic vascular diseases.
Source: British Journal of Pharmacology - December 2, 2014 Category: Drugs & Pharmacology Authors: WS Cheang, XY Tian, WT Wong, Y Huang Tags: Review Article – Chinese innovation in cardiovascular drug discovery Themed Issue Source Type: research

The peroxisome proliferator‐activated receptors in cardiovascular diseases: experimental benefits and clinical challenges
This article reviews the cardiovascular effects of PPARs, with emphasis on the therapeutic potential of PPAR agonists in combating metabolic vascular diseases.
Source: British Journal of Pharmacology - January 23, 2015 Category: Drugs & Pharmacology Authors: Wai San Cheang, Xiao Yu Tian, Wing Tak Wong, Yu Huang Tags: REVIEW Source Type: research

Elastase ‐2, an angiotensin II‐generating enzyme, contributes to increased Ang II in resistance arteries of mice with myocardial infarction.
Abstract Angiotensin II (Ang II), whose generation largely depends on angiotensin‐converting enzyme activity, mediates most of the renin‐angiotensin‐system effects. Elastase‐2 (ELA‐2), a chymotrypsin‐serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved on Ang II‐generation in resistance arteries are unknown. We hypothesized that ELA‐2 contributes to vascular Ang II generation and to cardiac damage in mice submitted to MI. Concentration‐effect curves to Ang I and Ang II were performed i...
Source: British Journal of Pharmacology - February 21, 2017 Category: Drugs & Pharmacology Authors: Christiane Becari, Marcondes A. B. Silva, Marina T. Durand, Cibele M. Prado, Eduardo B. Oliveira, Mauricio S. Ribeiro, Helio C. Salgado, Maria Cristina O. Salgado, Rita C. Tostes Tags: RESEARCH PAPER Source Type: research

Elastase ‐2, an angiotensin II‐generating enzyme, contributes to increased angiotensin II in resistance arteries of mice with myocardial infarction
Conclusions and ImplicationsThese results provide the first evidence that ELA‐2 contributes to increased Ang II formation in resistance arteries and modulates cardiac function after MI, implicating ELA‐2 as a key player in ACE‐independent dysregulation of the RAS.
Source: British Journal of Pharmacology - April 5, 2017 Category: Drugs & Pharmacology Authors: Christiane Becari, Marcondes A B Silva, Marina T Durand, Cibele M Prado, Eduardo B Oliveira, Mauricio S Ribeiro, Helio C Salgado, Maria Cristina O Salgado, Rita C Tostes Tags: RESEARCH PAPER Source Type: research