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Influence of CREST on CEA and CAS Trends in Women - Do the Results Matter? (I8-1.007)
CONCLUSION: Similar to the finding reported in CREST, women have a higher incidence of postoperative complications with carotid artery stenting in our cohort. The trends in the choice of procedure in women have not changed significantly after the CREST Study.Disclosure: Dr. Khalid has nothing to disclose. Dr. Reddy has nothing to disclose. Dr. Rajamani has nothing to disclose. Dr. Bhattacharya has nothing to disclose. Dr. Seraji-Bozorgzad has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khalid, S., Reddy, S., Chaturvedi, S., Rajamani, K., Bhattacharya, P., Seraji-Bozorgzad, N. Tags: Clinical Decision Making After the Dust Settles on Clinical Trials Poster Presentations Source Type: research

Cerebral Ischemic Events Associated with Intravenous Thrombolytic Administration in International Joint Efficacy Comparison of Thrombolytics (INJECT) Trial (P7.124)
Conclusions: Most cerebral ischemic events occur in the immediate post-thrombolytic period and result in disproportionately low survival over 6 months.Disclosure: Dr. Tasneem has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Suri has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Tasneem, N., Adil, M., Suri, M., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Issues in Acute Stroke Treatment Source Type: research

Influence of CREST on CEA and CAS Trends in Women - Do the Results Matter? (P7.166)
CONCLUSION: Similar to the finding reported in CREST, women have a higher incidence of postoperative complications with carotid artery stenting in our cohort. The trends in the choice of procedure in women have not changed significantly after the CREST Study.Disclosure: Dr. Khalid has nothing to disclose. Dr. Reddy has nothing to disclose. Dr. Rajamani has nothing to disclose. Dr. Bhattacharya has nothing to disclose. Dr. Seraji-Bozorgzad has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khalid, S., Reddy, S., Chaturvedi, S., Rajamani, K., Bhattacharya, P., Seraji-Bozorgzad, N. Tags: Cerebrovascular Disease and Interventional Neurology: Carotid Disease Source Type: research

Are Carotid Artery Stenosis-Isolated and Carotid Artery-Plus Two Distinct Entities? (P7.172)
CONCLUSIONS: CAS-isolated and CAS-plus appear to be two distinct entities with unique demographic and clinical attributes.Disclosure: Dr. Jani has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Hussain has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Jani, V., Malik, A., Hussain, S., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Carotid Disease Source Type: research

Spinning Out of Control: The Black Box of Basilar and Hemiplegic Migraine (P7.176)
CONCLUSIONS:In this retrospective study, triptans were used effectively with no subsequent vascular events for the abortive treatment of migraines with basilar and hemiplegic features. This data also suggests that beta blockers, tricyclic anti-depressants, anti-convulsants, and Botox injections have some efficacy in the treatment of migraines with basilar type and hemiplegic features.Disclosure: Dr. Krel has nothing to disclose. Dr. Mathew has nothing to disclose. Dr. Spinner has received personal compensation for activities with Merz Pharma and Allergan Inc. as speaker bureau member. Dr. Joshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Krel, R., Mathew, P., Spinner, W., Joshi, S. Tags: Headache: Treatment Source Type: research

High Burden of Brain Microvascular Disease in Difficult-to-Control Hypertension (P6.276)
CONCLUSION: requirement of a therapeutic strategy involving combination of multiple drugs generally indicates more severe underlying hypertensive disease. It is possible that mechanisms of endothelial dysfunction responsible of the neurovascular unit damage might remain active despite achieving BP target.Disclosure: Dr. Zurru has nothing to disclose. Dr. Alonzo has nothing to disclose. Dr. Brescacin has nothing to disclose. Dr. Luzzi has nothing to disclose. Dr. Camera has nothing to disclose. Dr. Waisman has nothing to disclose. Dr. Cristiano has received personal compensation for activities with Bayer Pharmaceuticals Cor...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Zurru, M., Alonzo, C., Brescacin, L., Luzzi, A., Camera, L., Waisman, G., Cristiano, E. Tags: Cerebrovascular Disease and Interventional Neurology: Risk Factors Source Type: research

Comparison Of Classical Risk Factors, Lypids, Stress And Depression Among Patients With First Ischemic Stroke And Acute Myocardial Infarction In A Center From Buenos Aires. (P6.277)
Conclusions: Smoking and dyslipemia were more frequent in AMI. IS patients were older. ApoB and ApoA levels were lower in AMI. Mild depressive symptoms were significantly more frequent in men with AMI.Disclosure: Dr. Lisei has nothing to disclose. Dr. Lopez Vicchi has nothing to disclose. Dr. Persi has nothing to disclose. Dr. Failo has nothing to disclose. Dr. Iglesias has nothing to disclose. Dr. Ballarino has nothing to disclose. Dr. Camerlingo has nothing to disclose. Dr. Parisi has nothing to disclose. Dr. Gatto has received personal compensation for activities with Tuteur as a scientific advisor, and Bago, Novartis, ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lisei, D., Lopez Vicchi, M., Persi, G., Failo, M., Iglesias, R., Ballarino, M., Camerlingo, S., Parisi, V. L., Gatto, E. Tags: Cerebrovascular Disease and Interventional Neurology: Risk Factors Source Type: research

Incident Cancer in Stroke Survivors: Analysis of the Vitamin Intervention for Stroke Prevention (VISP) Trial (P5.114)
Conclusions: Incident cancer is not uncommon and is associated with lower survival among stroke survivors.Disclosure: Dr. Suri has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Rodriguez has nothing to disclose. Dr. Nickles has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Suri, M., Adil, M., Rodriguez, G., Chaudhry, S., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Epidemiology Source Type: research

"On-the-job" Fatal Cardiovascular Events: Analysis of National Institute for Occupational Safety and Health Data (P5.120)
Conclusions: "On-the-job" cardiovascular events occur relatively frequently particularly after vigorous activity and appropriate screening and preparedness is recommended.Disclosure: Dr. Zarar has nothing to disclose. Dr. Saed has nothing to disclose. Dr. Tasneem has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Zarar, A., Saed, A., Tasneem, N., Adil, M., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Epidemiology Source Type: research

Troponin Elevation in Intra-arterial Stroke Intervention (P4.211)
CONCLUSIONS: Aggressive treatment may increase the risk of troponin elevation without increasing mortality in AIS patients. This finding is reassuring in view of continued interest in IA treatment of stroke in addition to tPA thrombolysis.Disclosure: Dr. Kumar has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Alawi has nothing to disclose. Dr. Michael has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Kumar, A., Mehta, S., Alawi, A., Michael, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Endovascular Source Type: research

Safety of Dihydroergotamine Use in Patients with Symptoms of Hemiplegic or Basilar Type Migraine (P7.200)
ConclusionDihydroergotamine use showed no serious adverse events in this case series of patients meeting ICHD II criteria for migraine in whom HM or BTM was suggested. Study limitations preclude generalizability of results to other populations. Additional case series are needed before prospective trials can be justified.Disclosure: Dr. Klein has received personal compensation for activities with Allergan, Inc., Zogenix, UCB Pharma, Nautilus, and US WorldMeds. Dr. Hanna has nothing to disclose. Dr. Buddhdev has nothing to disclose. Dr. Naglak has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Klein, B., Hanna, W., Buddhdev, B., Naglak, M. Tags: Headache: Treatment Source Type: research

Effect of Carotid Revascularization Endarterectomy Versus Stenting Trial Results on Performance of Carotid Artery Stent Placement and Carotid Endarterectomy in United States (S51.005)
Conclusion: The frequency of CAS and CEA for carotid artery stenosis has not changed after the publication of CREST trial. The demographics, pre-treatment co-morbidity profile and in-hospital complications remain unchanged during the two time periods. CAS continues to have higher risk of post-operative neurological complications as reported in CREST trial.Disclosure: Dr. Siddiq has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Nickles has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Siddiq, F., Adil, M., Malik, A., Chaudhry, S., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Large Vessel Atherosclerotic Disease Source Type: research

Overview of Arterial Thromboembolic Events (ATEs) in AVAglio, a Randomized, Placebo-controlled Phase III Trial of Bevacizumab, Radiotherapy and Temozolomide (BEV+RT/TMZ) for Newly Diagnosed Glioblastoma (S22.003)
CONCLUSION: More ATEs were reported in the BEV+RT/TMZ versus Plb+RT/TMZ arm. ATEs in the BEV+RT/TMZ arm tended to occur late in the study and may be related to prolonged treatment duration/co-morbidities, however the majority resolved (two-thirds with sequelae). Study supported by: F. Hoffmann-La Roche LtdDisclosure: Dr. Mason has received personal compensation for activities with Roche Diagnostics Corporation. Dr. Cloughsey has received personal compensation for activities with F. Hoffman-La Roche, Genentech Inc., Merck & Co. Inc., Merck & Co. Inc., Serono Inc., Celgene, Tocagen, Apogenix, and Newgen. Dr. Wick has...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Mason, W., Cloughesy, T., Wick, W., Henriksson, R., Saran, F., Nishikawa, R., Dhar, S., Revil, C., Garcia, J., Chinot, O. Tags: Neuro-oncology Source Type: research

Free fatty acids to predict recurrent ischemic stroke
Recurrent stroke accounts for substantial morbidity and mortality among ischemic stroke survivors. To establish effective treatments for secondary stroke prevention, it is important to determine factors associated with stroke recurrence. Among the blood biomarkers associated with stroke risk, lipoprotein-associated phospholipase A2 (LpPLA2) is perhaps the most studied. LpPLA2 hydrolyzes oxidized phospholipids and plays an important role in atherosclerosis with elevated plasma levels associated with increased risk of ischemic stroke and myocardial infarction. Other markers associated with stroke risk include fibrinogen, C-r...
Source: Neurology - March 31, 2014 Category: Neurology Authors: Jickling, G. C., Spence, J. D. Tags: All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Herpes zoster as a risk factor for stroke and TIA: A retrospective cohort study in the UK
Conclusion: HZ is an independent risk factor for vascular disease in the UK population, particularly for stroke, TIA, and MI in subjects affected before the age of 40 years. In older subjects, better ascertainment of vascular risk factors and earlier intervention may explain the reduction in risk of stroke after the occurrence of HZ.
Source: Neurology - January 20, 2014 Category: Neurology Authors: Breuer, J., Pacou, M., Gauthier, A., Brown, M. M. Tags: Stroke in young adults, Viral infections, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

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