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Source: Neurology
Condition: Dementia

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Total 240 results found since Jan 2013.

Von Willebrand Factor and the Risk of Dementia: A Population-Based Study (P1.092)
Conclusions: Higher levels of Von Willebrand factor are associated with an increased risk of dementia, including Alzheimer’s disease, possibly due to direct prothrombotic effects or secondary to endothelial injury.Disclosure: Dr. Wolters has nothing to disclose. Dr. Boender has nothing to disclose. Dr. Hofman has nothing to disclose. Dr. De Maat has nothing to disclose. Dr. Koudstaal has nothing to disclose. Dr. Leebeek has received research support from Baxter and CSL Behring. Dr. Ikram has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Wolters, F., Boender, J., Hofman, A., De Maat, M., Koudstaal, P., Leebeek, F., Ikram, M. Tags: Epidemiology of Aging and Dementias Source Type: research

Poststroke spasticity: Treating to the disability
People who have strokes are subject to numerous potentially devastating sequelae, most often sensorimotor paresis, impairment of cognition and language, and other functional disabilities, including depression and dementia. Of these sequelae, spasticity occurring with motor dysfunction is a frequent finding that has to be evaluated in light of other diagnoses, such as central paresis, ataxia, pathologic stance or gait, and other coordination dysfunctions. Often, spasticity is not notably present in acute ischemic strokes but develops later on, and may then become a major obstacle for achieving independence in performance of...
Source: Neurology - January 14, 2013 Category: Neurology Authors: Brainin, M. Tags: INTRODUCTION Source Type: research

Prevalence of Cerebrovascular Events in Extraluminal Protruding Intracranial Atherosclerotic Plaques: Analysis of Intracranial Vessels from the Nun Study (P03.009)
CONCLUSIONS: Outside protruding plaques without angiographic stenosis appear to be responsible for ischemic events in patients with cryptogenic stroke. Higher prevalence of stroke in these patients warrants the use of newer imaging modalities like high resolution magnetic resonance imaging to identify patients who are at high risk of cerebrovascular events.Disclosure: Dr. Semaan has nothing to disclose. Dr. Majidi has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. Santa Cruz has nothing to disclose. Dr. Suri has nothing to disclose. Dr. ATACH Investigators has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Semaan, E., Majidi, S., Chaudhry, S., Santa Cruz, K., Suri, M. F., Qureshi, A. Tags: P03 Child Neurology II Source Type: research

Adherence to a Mediterranean diet and risk of incident cognitive impairment
Conclusions: Higher adherence to MeD was associated with a lower likelihood of ICI independent of potential confounders. This association was moderated by presence of diabetes mellitus.
Source: Neurology - April 29, 2013 Category: Neurology Authors: Tsivgoulis, G., Judd, S., Letter, A. J., Alexandrov, A. V., Howard, G., Nahab, F., Unverzagt, F. W., Moy, C., Howard, V. J., Kissela, B., Wadley, V. G. Tags: All Cognitive Disorders/Dementia, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Intermittent Temporal Slowing in Cognitively Normal Oldest-old: The 90+ EEG Study (P3.214)
CONCLUSIONS: In this preliminary study, asymptomatic ITS was not associated with subsequent cognitive decline in healthy oldest-old participants. ITS may represent a benign, aging phenomenon, as opposed to an underlying pathological process, and may not require further clinical work-up in the oldest-old. However, the small sample size limits our statistical power and the results warrant a larger study to confirm the findings.Study supported by: NIH grants T32NS045540 and R01AG21055 Disclosure: Dr. Bullain has nothing to disclose. Dr. Corrada has nothing to disclose. Dr. Greenia has nothing to disclose. Dr. ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Bullain, S., Corrada, M., Greenia, D., Kawas, C. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Clinical Aspects Source Type: research

Taking Neurology to the Underserved - A Pilot Initiative in an Urban Homebound Program (P6.007)
CONCLUSIONS: Our pilot program highlights types of chronic neurologic illnesses afflicting the homebound population, treatment interventions utilized, and clinical challenges encountered. By considering the real-world intersection of disease and living environment, trainees gained perspective on the debilitating impact of neurological illness on homebound patients. This pilot program reveals the need and feasibility of neurological home based care as an important clinical, educational, and palliative paradigm.Disclosure: Dr. Ramdhani has nothing to disclose. Dr. Fabian has received personal compensation for activities with...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ramdhani, R., Fabian, M., Wajnberg, A., DeCherrie, L., Krieger, S. Tags: General Neurology V Source Type: research

Hypercholesterolemia and Neurological Diseases Related Mortality in the NEDICES Cohort (P6.030)
CONCLUSIONS: Long-term overall mortality rate is lower among elderly subjects with HC when compared to those without HC. This association is justified mainly by a decrease in non-cardiovascular mortality, without any association of HC with cause-specific or combined cardiovascular or neurological causes of mortality.Study Supported by: Instituto de Salud Carlos III (ISCIII), Spain.Disclosure: Dr. Sierra-Hidalgo has nothing to disclose. Dr. Sanchez-Ferro has nothing to disclose. Dr. Trincado has nothing to disclose. Dr. Díaz Guzmán has nothing to disclose. Dr. Hernández Gallego has nothing to disclose. ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sierra-Hidalgo, F., Sanchez-Ferro, A., Trincado, R., Diaz Guzman, J., Hernandez Gallego, J., Benito-Leon, J., Vega, S., Bermejo-Pareja, F. Tags: General Neurology VI Source Type: research

Cognitive Deficits of Large-Vessel and Small-Vessel Vascular Dementia (P6.238)
CONCLUSIONS: Patients with small-vessel VaD are more impaired than patients with large-vessel VaD in the patterns of cognitive deficits. Small-vessel VaD may contribute to cognitive decline by affecting language, visuospatial function and frontal/executive function.Study Supported by:Disclosure: Dr. Na has nothing to disclose. Dr. Yoo has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Na, J.-Y., Yoo, B.-G. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Memory Source Type: research

Spatial Neglect Commonly Occurs after Traumatic Brain Injury (P7.289)
CONCLUSIONS: The occurrence of SN following TBI is common: more than one quarter of TBI patients had SN. This finding warrants further examination of its prevalence and impact on recovery, especially in the cognitive domain, following a TBI.Study Supported by: Kessler FoundationDisclosure: Dr. Chen has nothing to disclose. Dr. Ward has nothing to disclose. Dr. Hreha has received personal compensation for activities with Kessler Institute for Rehabilitation. Dr. Liu has nothing to disclose. Dr. Khan has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Chen, P., Ward, I., Hreha, K., Liu, Y., Khan, U. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Attention/Neglect Source Type: research

Leftward Where Bias And Rightward Distraction In Chronic Neglect. (P7.293)
CONCLUSIONS: We replicated previously reported, leftward Where bias in chronic neglect. Future longitudinal research can explore whether ipsilateral neglect caused rightward Aiming errors with right distraction, or whether occurs typically in contralesional neglect. N- participants demonstrated near, not far, asymmetric Aiming. Whether our findings relate to visuo-motor function instroke /neglect (e.g. fall risk) requires further study.Study Supported by: NIDRR/NIHDisclosure: Dr. Barrett has received personal compensation for activities with WebMD. Dr. Barrett has received research support from Kessler Foundation, National...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Barrett, A., Goedert, K., Oh-Park, M. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Attention/Neglect Source Type: research

Plasma Lipids and Cerebral Small Vessel Disease (S40.002)
CONCLUSIONS: Increasing triglycerides but not other lipid fractions were associated with MRI-markers of cerebral small vessel disease in older community persons.Disclosure: Dr. Schilling has nothing to disclose. Dr. Tzourio has received personal compensation for activities with Abbott, and Servier. Dr. Dufouil has received personal compensation for activities with Eisai Inc. as a consultant. Dr. Zhu has nothing to disclose. Dr. Berr has nothing to disclose. Dr. Alpérovitch has nothing to disclose. Dr. Crivello has nothing to disclose. Dr. Mazoyer has nothing to disclose. Dr. Debette has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Schilling, S., Tzourio, C., Dufouil, C., Zhu, Y., Berr, C., Alperovitch, A., Crivello, F., Mazoyer, B., Debette, S. Tags: General Neurology II Source Type: research

Factor Scores for Brain Reserve, Alzheimer and Vascular Pathology are Independent Risk Factors for Dementia in a Population-based Cohort Study: The Kame Project (S58.006)
CONCLUSIONS: Brain reserve appears to play a very important role in buffering the effects of Alzheimer and vascular pathology on dementia risk. Simple reaction time, which clustered with education and verbal IQ, provides an easily-obtained measure of reserve.Study Supported by: NIA: R01 AG09769.Disclosure: Dr. Borenstein has nothing to disclose. Dr. Mortimer has nothing to disclose. Dr. Larson has received royalty payments from UpToDate.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Borenstein, A., Mortimer, J., Larson, E. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Clinical Aspects Source Type: research

Comparing Semi-quantitative and Volumetric Measurements of MRI White Matter Hyperintensities: The Northern Manhattan Study (S62.007)
CONCLUSIONS: Our volumetric and visual rating measures of WMH were strongly correlated, but the volumetric measure was associated with more risk factors in this community-based sample. User-friendly WMH scales that capture vascular risk are needed to develop risk-prediction scores for WMH lesion burden.Study Supported by:Evelyn F. McKnight Brain Institute and NINDS (R37 NS 29993; K02 NS 059729)Disclosure: Dr. Oboudiyat has nothing to disclose. Dr. Gardener has nothing to disclose. Dr. Marquez has nothing to disclose. Dr. Sacco has nothing to disclose. Dr. DeCarli has received personal compensation in an editorial capacity ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Oboudiyat, C., Gardener, H., Marquez, C., Elkind, M., Sacco, R., DeCarli, C., Wright, C. Tags: Cerebrovascular Disease and Interventional Neurology: Cognitive and Behavioral Source Type: research

Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy
Conclusion: Lower serum levels of IGF-1 are associated with an increased risk of developing AD dementia and higher levels with greater brain volumes even among middle-aged community-dwelling participants free of stroke and dementia. Higher levels of IGF-1 may protect against subclinical and clinical neurodegeneration.
Source: Neurology - May 5, 2014 Category: Neurology Authors: Westwood, A. J., Beiser, A., DeCarli, C., Harris, T. B., Chen, T. C., He, X.-m., Roubenoff, R., Pikula, A., Au, R., Braverman, L. E., Wolf, P. A., Vasan, R. S., Seshadri, S. Tags: MRI, Endocrine, Alzheimer's disease, Cohort studies ARTICLE Source Type: research

Vitamin D and the risk of dementia and Alzheimer disease
Conclusion: Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions.
Source: Neurology - September 1, 2014 Category: Neurology Authors: Littlejohns, T. J., Henley, W. E., Lang, I. A., Annweiler, C., Beauchet, O., Chaves, P. H. M., Fried, L., Kestenbaum, B. R., Kuller, L. H., Langa, K. M., Lopez, O. L., Kos, K., Soni, M., Llewellyn, D. J. Tags: All Cognitive Disorders/Dementia, Alzheimer's disease ARTICLE Source Type: research