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Source: Neurology
Condition: Dementia
Education: Education

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Total 54 results found since Jan 2013.

Comparison of symptomatic and asymptomatic persons with primary age-related tauopathy
Conclusions: These findings support the hypothesis that participants with PART have an amyloid-independent dementing Alzheimer disease–like temporal lobe tauopathy.
Source: Neurology - October 16, 2017 Category: Neurology Authors: Besser, L. M., Crary, J. F., Mock, C., Kukull, W. A. Tags: All Clinical Neurology, Prognosis, Depression, All Cognitive Disorders/Dementia, Cognitive aging ARTICLE Source Type: research

Association of parathyroid hormone with 20-year cognitive decline: The ARIC study
Conclusions: Our work does not support an independent influence of PTH on cognitive decline in this population-based cohort study.
Source: Neurology - August 28, 2017 Category: Neurology Authors: Kim, S. M., Zhao, D., Schneider, A. L. C., Korada, S. K., Lutsey, P. L., Guallar, E., Alonso, A., Windham, B. G., Gottesman, R. F., Michos, E. D. Tags: Endocrine, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Structural MRI markers of brain aging early after ischemic stroke
Conclusions: Brain structure is likely to be compromised before ischemic stroke by vascular risk factors. Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.
Source: Neurology - July 10, 2017 Category: Neurology Authors: Werden, E., Cumming, T., Li, Q., Bird, L., Veldsman, M., Pardoe, H. R., Jackson, G., Donnan, G. A., Brodtmann, A. Tags: MRI, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Alzheimer's disease, Vascular dementia ARTICLE Source Type: research

MCI subtypes are heterogeneous and preceded by different risk factors: A study on aMCI and naMCI incidence (P4.194)
Conclusions:Results suggested that aMCI and naMCI are inherently heterogeneous from the outset, illustrated by their different risk factors. Recognizing indicators of MCI prior to clinical presentation is critical in targeted interventions, early treatment, and prevention from rapid progression to dementia.Study Supported by:NIA grant: AG03949Sylvia and Leonard Marx FoundationDisclosure: Dr. Zammit has nothing to disclose. Dr. Lipton has received personal compensation from Allergan, American Headache Society, Autonomic Technologies, Boston Scientific, Bristol Myers Squibb, Cognimed, Colucid, Eli Lilly, eNeura Therapeutics,...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zammit, A., Lipton, R., Katz, M., Derby, C., Hall, C. Tags: Behavioral and Cognitive Neurology: Neurodegenerative Disorders Source Type: research

HELIAD study: Dementia prevalence in Greece (P3.095)
Conclusions:The prevalence of dementia and its subtypes in Greece is similar or at the lower range of that reported in many other European countries and globally. In our sample, increased age and decreased level of education status, but not gender, were predictive of a diagnosis of dementia with age being the strongest predictive factor.Study Supported by:Funding/Support: IIRG-09-133014 from the Alzheimer’s Association; 189 10276/8/9/2011 from the ESPA-EU program Excellence Grant (ARISTEIA) which is co-funded by the European Social Fund and Greek National resources; and Y2β/o.51657/14.4.2009 from the Ministry fo...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Sakka, P., Kosmidis, M., Yannakoulia, M., Dardiotis, E., Hadjigeorgiou, G., Scarmeas, N. Tags: Aging and Dementia: Epidemiologic Studies Source Type: research

Dextromethorphan/Quinidine Improved Symptoms of Pseudobulbar Affect Irrespective of Concomitant Antidepressant Use (P6.210)
Conclusions:In this analysis, DM/Q was associated with PBA symptom improvement regardless of concomitant antidepressant use at baseline.Study Supported by: Avanir Pharmaceuticals, Inc.Disclosure: Dr. Formella has received personal compensation for activities with Avanir Pharmaceuticals, Inc. as an employee. Dr. Alexander has nothing to disclose. Dr. Cutler has received personal compensation for activities with Acadia, Alkermes, Allergan, Arbor Pharmaceuticals, Avanir, Intra-Cellular Therapies, Ironshore, and Lundbeck. Dr. Cutler has received research support from Acadia, Akili, Interactive, Alkermes, Allergan, Avanir, Axso...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Formella, A. E., Alexander, D. N., Cutler, A. J., DAmico, S., Hammond, F. M., Sauve, W., Zorowitz, R. D., Siffert, J. Tags: Behavioral and Cognitive Neurology: Emotion/Behavior Source Type: research

Predictive Variables of Cognitive Dysfunction in Patients with Lupus (P1.340)
Conclusions:Duration of disease and low educational level are predictors of CD in patients with SLE. Depression and anxiety did not influence cognitive performance. Although cardiovascular comorbidity is a risk factor for dementia in general population, those variables might play a minor role in SLE patients.Study Supported by:Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and São Paulo Research Foundation (FAPESP) (grant #2015/08833-7) supported this study.Disclosure: Dr. Alessi has nothing to disclose. Dr. Dutra Antonio has nothing to disclose. Dr. Maria has nothing...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Alessi, H., Dutra, L. A., Maria, L., Xavier, P., Couce, P., Kayser, C., Barsottini, O. Tags: CNS Inflammatory Diseases and Differential Diagnosis I Source Type: research

Elevated cerebrospinal fluid total Tau levels reflects predominant cortical involvement in Alzheimers disease (P1.093)
Conclusions:Elevated CSF Tau levels in AD patients could be surrogate biomarker for AD subtypes with predominant early cortical symptoms and atrophy. There is a need for a systematic prospective unbiased follow-up to see if rapid clinical progression in AD is related to elevated T-Tau and distinct AD subtypes.Disclosure: Dr. Pillai has nothing to disclose. Dr. Khrestian has nothing to disclose. Dr. Bekris has nothing to disclose. Dr. Safar has nothing to disclose. Dr. Leverenz has received personal compensation for activities with Axovant, GE Healthcare and Navidea Biopharmaceuticals as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Pillai, J., Khrestian, M., Bekris, L., Safar, J., Leverenz, J. Tags: Aging and Dementia: Biomarkers Source Type: research

Association between frequency of sleep medication use and brain morphology (P3.058)
Conclusions:This is the first study to examine the association between frequency of sleep medication use and brain morphology in a healthy group of older adults. Metabolic effects or a possible neurotoxicity could play a role to the observed associations.Study Supported by:NIH R01AG038465-02NIH R01AG026158-07Research programs of excellence IKY/SIEMENS for Angeliki Tsapanou, Nikolao ScarmeaDisclosure: Dr. Tsapanou has nothing to disclose. Dr. Gu has nothing to disclose. Dr. Haider has nothing to disclose. Dr. Stern has received personal compensation for activities with Takeda, Axovant, and Eli Lilly and Company as an adviso...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tsapanou, A., Gu, Y., Haider, L., Sakhardande, J., Scarmeas, N., Stern, Y. Tags: Sleep Disruption and Medical Co-Morbidities Source Type: research

A Brief Dementia Screening Test in South Africa: Results from the Health and Aging Longitudinal Study of an INDEPTH community (HAALSI) (P4.191)
Conclusions:There is a potentially protective and long-lasting impact of secondary school education on cognitive status later in life in this setting. Using a brief screening test in this relatively poor cohort of older South Africans, patterns of low cognition are similar to those in the USA and other countries.Study Supported by:The National Institute on Aging at the National Institute of Health (NIH) (1P01AG041710-01A1; 1R01AG051144–01; 3U54HG006938-03S1). F. Mateen is supported by a subgrant of P30AG024409 from the NIH for the Harvard Center for Global Demography and Aging. The Agincourt HDSS was supported by the...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mateen, F., Jennings, E., Montana, L., Wagner, R., Kahn, K., Tollman, S., Berkman, L. Tags: Behavioral and Cognitive Neurology: Neurodegenerative Disorders Source Type: research

Aerobic exercise and vascular cognitive impairment: A randomized controlled trial
Conclusions: This study provides preliminary evidence for the efficacy of 6 months of thrice-weekly progressive aerobic training in community-dwelling adults with mild SIVCI, relative to usual care plus education. ClinicalTrials.gov identifier: NCT01027858. Classification of evidence: This study provides Class II evidence that for adults with mild SIVCI, an aerobic exercise program for 6 months results in a small, significant improvement in ADAS-Cog performance.
Source: Neurology - November 13, 2016 Category: Neurology Authors: Liu-Ambrose, T., Best, J. R., Davis, J. C., Eng, J. J., Lee, P. E., Jacova, C., Boyd, L. A., Brasher, P. M., Munkacsy, M., Cheung, W., Hsiung, G.-Y. R. Tags: All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Vascular dementia, Class I ARTICLE Source Type: research

China's shift from population control to population quality: Implications for neurology
China's population restriction, known across the globe as the 1-child policy, has been in place since 1981, with variations to allow some couples a second child.1,2 In response to social challenges arising from this policy, the Chinese government announced in 2015 that it would transition to a new 2-child policy, encouraging couples since January 1, 2016, to have 2 children.3 This transition accompanies a focus on population quality (i.e., improvements in health, education, and social welfare) in newborns to the large Chinese elderly population, with an initiative to reform the Chinese health care system and increase disea...
Source: Neurology - August 21, 2016 Category: Neurology Authors: Ke, Q., Zhang, L., He, C., Zhao, Z., Qi, M., Griggs, R. C., Gatheridge, M. A. Tags: Stroke prevention, All Neuromuscular Disease, All Cognitive Disorders/Dementia GLOBAL PERSPECTIVES Source Type: research

Prognostic Risk Profiles for Dementia: A Machine Learning Approach (P1.091)
Conclusions: These results suggest that vascular factors may play a greater role in dementia pathogenesis than currently thought. Furthermore, using this method we were able to achieve prediction accuracies that compare favorably with the existing literature.Disclosure: Dr. Morgenstern has nothing to disclose. Dr. Daley has nothing to disclose. Dr. Hachinski has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Morgenstern, J., Daley, M., Hachinski, V. Tags: Epidemiology of Aging and Dementias Source Type: research

Temporal and Racial Trends in Post-Stroke Dementia in the "Stroke Buckle" of the United States (P1.099)
CONCLUSIONS: Over the last decade, incidence of PSD significantly increased in South Carolina. Black stroke patients had higher overall rates of PSD than whites, but this difference was largely driven by a comparatively greater burden of Non-AD dementia. Since Non-AD dementia is predominantly composed of vascular dementia, better vascular risk factor control may help bridge this racial disparity.Disclosure: Dr. Boan has nothing to disclose. Dr. Lackland has nothing to disclose. Dr. Feng has nothing to disclose. Dr. Voeks has nothing to disclose. Dr. Adams has received personal compensation for activities with Reach Call In...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Boan, A., Lackland, D., Feng, W., Voeks, J., Adams, R., Bachman, D., Ovbiagele, B. Tags: Neuroepidemiology: Aging and Dementia, Epilepsy, and Education Source Type: research

Increasing Skeletal Muscle Mass Could Prevent Stroke (P1.177)
Conclusion: High SMM group had low WMC/SI, especially in men. Increased SMM by muscle strengthening exercise may prevent stroke.Disclosure: Dr. Minn has nothing to disclose. Dr. Suk has nothing to disclose. Dr. Koh has nothing to disclose. Dr. Hwang has nothing to disclose. Dr. Park has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Song has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Minn, Y. K., Suk, S. H., Koh, I. S., Hwang, S.-H., Park, J. H., Lee, J. H., Song, H. Tags: Cerebrovascular Disease: Risk Factors and Prevention Source Type: research