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Source: Neurology
Condition: Autoimmune Disease

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Total 31 results found since Jan 2013.

Ischemic Stroke as the Presenting Symptom in a Young Patient with Essential Thrombocythemia Caused by CALR Gene Mutation (P2.253)
CONCLUSIONS: Ischemic stroke is a rare complication of essential thrombocythemia and this case is unusual because of multiple strokes in a very young patient as the presenting symptom. Fortunately, the condition was recognized and successfully treated with aspirin and hydroxyurea. She was not left with any residual neurological deficits. This case demonstrates another unusual and rarely reported cause for stroke in a young patient.Disclosure: Dr. Anderson has nothing to disclose. Dr. Bonsell has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Anderson, N., Bonsell, K. Tags: Cerebrovascular Disease and Interventional Neurology: Genetics and Stroke Source Type: research

Autoimmune thyroiditis as a risk factor for stroke: A historical cohort study
Conclusion: Our results support the hypothesis of a slightly increased risk of stroke in patients with AIT. The higher effect size found soon after AIT diagnosis suggests an increased cardiovascular risk due to thyroid-hormone deficiency rather than a cumulative effect of autoimmune pathology. Better screening and early treatment of patients with asymptomatic hypothyroid AIT could help reduce excess risk of stroke in the first year after diagnosis.
Source: Neurology - May 5, 2014 Category: Neurology Authors: Karch, A., Thomas, S. L. Tags: Stroke prevention, Autoimmune diseases, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Comment: Does L-thyroxine prevent or cause stroke in hypothyroidism?
The association between overt hypothyroidism and atherosclerotic risk factors, especially hypertension and dyslipidemia, is clear. To date, only a few small and methodologically flawed epidemiologic studies have investigated the relationship between hypothyroidism and stroke, precluding definitive conclusions. In the current issue of Neurology®, Karch and Thomas1 present a large well-designed case-control study investigating this relationship. They compared 34,907 patients with autoimmune thyroiditis on treatment with l-thyroxine and 149,632 matched individuals without autoimmune thyroiditis from a UK primary care elec...
Source: Neurology - May 5, 2014 Category: Neurology Authors: Squizzato, A., Gerdes, V. E. A. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Stroke In Young Adults: A 4-Year Retrospective Hospital-Based Study, First Report From United Arab Emirates (P1.020)
CONCLUSIONS: Stroke in young adults is prevalent in our region; main cause is unknown. The increased mortality in this age population is alarming requiring better risk-factor control measures. MR: Mortality rates, ICH: intracerebral hemorrhage, SAH: subarachnoid hemorrhageDisclosure: Dr. AlAmeri has nothing to disclose. Dr. AlNuaimi has nothing to disclose. Dr. Alsaadi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: AlAmeri, M., AlNuaimi, A., Alsaadi, T. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research

Stroke Due To Extracranial Internal Carotid Artery Dissection After Roller Coaster Rides In A 4-Year-Old Boy (P7.343)
CONCLUSIONS: To our knowledge this is the youngest patient with stroke secondary to ICA dissection following roller-coaster rides. Although the exact mechanism of injury leading to ICA dissection in the setting of sudden linear acceleration, deceleration and rotational forces such as those experienced while riding a roller coaster is not fully understood, these injuries have been attributed to brief sustained excessive gravitational forces likely augmented among predisposed individuals. Children may be at higher risk due to the immature anatomy of their cervical spine. Alterations to roller coaster ride dynamics and use of...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nouh, A., Vela-Duarte, D., Grobelny, T., Hoganson, G., Pasquale, D., Biller, J. Tags: Child Neurology and Developmental Neurology VI Source Type: research

Intracranial Fibromuscular Dysplasia in a Middle-Aged Woman with Recurrent Ischemic Stroke (P4.388)
Conclusions: FMD is a rare disease and has very rarely been described in the intracranial arteries. This case illustrates the natural history and progression of FMD in this patient and elucidates the limited treatment options for preventing disease progression and secondary complications. FMD most predominantly affects younger to middle-aged females and if the disease process goes unrecognized it can have devastating consequences. It is important to continue research endeavors into the genetic and biologic determinants of FMD in order to develop better prevention and therapeutic strategies for this condition.Disclosure: Dr...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Beaton, N., Malik, A., Maque-Acosta, Y., Koch, S. Tags: Non-Atherosclerotic Arteriopathies Source Type: research

Pearls & Oy-sters: Acute ischemic stroke caused by atypical thrombotic thrombocytopenic purpura
Source: Neurology - May 27, 2013 Category: Neurology Authors: Rojas, J. C., Banerjee, C., Siddiqui, F., Nourbakhsh, B., Powell, C. M. Tags: Stroke in young adults, Autoimmune diseases, All Medical/Systemic disease, Hematologic, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

Lasting Relief from Chronic Pain after Cerebral Infarction (P02.005)
CONCLUSIONS: This patient's stroke appeared to produce the beneficial and persistent effect of dramatic pain relief, enabling him to discontinue all analgesic medications, including methadone. The alleviation of pain after ischemic infarction is highly unusual, and possible explanations include 1) damage to both anterior cingulate gyri producing apathy of such severity that the experience of pain was markedly blunted, and 2) bilateral injury to the nucleus accumbens abolishing a cerebral region critical for the appreciation of pain and opiate-related reward.Disclosure: Dr. Burke has nothing to disclose. Dr. Anderson's spou...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Burke, H., Anderson, C., Filley, C. Tags: P02 Ethics, Pain, and Palliative Care Source Type: research

Giant-Cell Arteritis Presenting as Isolated Bilateral CN-VI Palsies: A Rare Case Report of a 65 Year Male. (P2.378)
Conclusions:GCA is the most prevalent systemic vasculitis in the elderly. It can present with a wide variety of symptoms ranging from fatigue, headache, visual loss, and even stroke. However as noted in this case, isolated CN-VI palsy can be a very rare, early manifestation of GCA. As GCA responds well to corticosteroid therapy, prompt diagnosis and treatment is critical to prevent and/or limit neurologic sequelae. As highlighted by this case, in the event of recurrent incidents and absence of other diagnosis; GCA should be considered even if headache is absent.Disclosure: Dr. Lunagariya has nothing to disclose. Dr. Patel ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lunagariya, A., Patel, U., Kotadiya, F., Wilson, C. Tags: CNS Inflammatory Diseases and Differential Diagnosis II Source Type: research

Primary Central Nervous System Vasculitis Triggered by Cytomegalovirus Encephalitis (P01.231)
CONCLUSIONS: Our case is the first reported case in the literature of proven CMV encephalitis triggering a subsequent non-infectious CNS vasculitis probably secondary to an autoimmune response. The absence of findings in the initial MRIs of the brain in spite of an intermittently symptomatic patient and the subsequent development of ischemic infarcts supports the theory of intermittent focal hypoperfusion, finally leading to infarction. The high clinical suspicion even with lack of clear evidence of the disease process and empirical treatment led to a successful clinical recovery.Disclosure: Dr. Rosales has nothing to disc...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Rosales, D., Garcia-Gracia, C., Salgado, E., Salanga, V. Tags: P01 Cerebrovascular Disease I Source Type: research

Acute Cerebral Infarction as the Presenting Feature of anti-PL-7 Anti-Synthetase Syndrome (P5.126)
CONCLUSIONS: Anti-PL7 is one of eight known aminoacyl-tRNA synthetase (ARS) antibodies. Emerging evidence would suggest that each ARS antibody has a distinct phenotype. There is one report of acute infarction with cerebral vasculitis and anti-Jo1 ARS autoantibody. This is the first report of stroke in association with anti-PL7 anti-synthetase syndrome. Increased recognition of this disorder will allow for better delineation of the phenotype. Study Supported by:Disclosure: Dr. McNicholas has nothing to disclose. Dr. Henry has nothing to disclose. Dr. Ryan has received personal compensation for activities with Novartis, Merc...
Source: Neurology - April 8, 2015 Category: Neurology Authors: McNicholas, N., Henry, M., Ryan, A. Tags: Cerebrovascular Disease and Interventional Neurology: Biomarkers and Emerging Science Source Type: research

Teaching NeuroImages: HIV-associated cerebral vasculopathy with multiple nodular aneurysms
HIV-associated cerebral vasculopathy with multiple aneurysms has been widely reported in children1 and has to be considered in HIV-infected patients with high CSF viral load, but only few cases in adults have been published so far. Nodular and fusiform aneurysms (figure, A–D) are a typical imaging finding2 that may lead to suspicion of an autoimmune etiology by mimicking polyarteritis nodosa. These aneurysms might carry clinical significance with regard to the risk of subarachnoid or intracerebral hemorrhage, or causing infarction through formation of emboli. Highly active antiretroviral therapy leads to remission of...
Source: Neurology - April 3, 2017 Category: Neurology Authors: Seiler, A., You, S.-J., Wagner, M., Klein, J. C. Tags: Stroke in young adults, All Imaging, Vasculitis, HIV, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

Moyamoya and ethnic diversity (P6.252)
Conclusions:Our study showed significant proportion of AA patients compared to other cohorts studied in the US. With the rise in MMS in different ethnicities in the US, further studies need to be conducted to get a better understanding of causes within these populations.Disclosure: Dr. Irshad has nothing to disclose. Dr. Schultz has nothing to disclose. Dr. Zahoor has nothing to disclose. Dr. Malik has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Irshad, K., Schultz, L., Zahoor, S., Malik, S. Tags: Non-Atherosclerotic Angiopathies and Cerebral Venous Thrombosis Source Type: research

A Case Report of Dihydroergotamine Administration for Status Migrainosus in a Patient on Longstanding Citalopram Causing a Fatal Reversible Cerebral Vasoconstriction Syndrome (RCVS) (P02.027)
CONCLUSIONS: We report this case report of fatal RCVS of a patient on long standing citalopram who developed this after being administered Dihydroergotamine for status migrainosus. As this is thought to be a self-limiting in terms of clinical features. However, some patients may have more severe focal neurologic symptoms and signs, including ischemic or hemorrhagic strokes as described in our patient.Disclosure: Dr. Asi has nothing to disclose. Dr. Gomes has nothing to disclose. Dr. Dani has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Asi, K., Gomes, J., Dani, D. Tags: P02 Cerebrovascular Disease II Source Type: research

Cystatin C as a Marker of Degeneration in Multiple Sclerosis (P03.241)
CONCLUSIONS: Cystatin C concentration decrease in RR form of MS could give evidence for high disease activity in this stage of the disease with high myelin damage and neurodegeneration.Supported by: Grant IGA MHCZ NT 12221-5/2010.Disclosure: Dr. Prikrylová Vranová has nothing to disclose. Dr. Sládková has nothing to disclose. Dr. Mares has nothing to disclose. Dr. Hlustík has nothing to disclose. Dr. Langová has nothing to disclose. Dr. Kanovsky has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Prikrylova Vranova, H., Sladkova, V., Mares, J., Hlustik, P., Langova, J., Kanovsky, P. Tags: P03 Multiple Sclerosis: Disease Biomarkers Source Type: research