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Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000-2012
Conclusions PLWHA had higher risks of incident Sjögren syndrome, psoriasis, SLE, autoimmune haemolytic anaemia and uveitis.
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Yen, Y.-F., Chuang, P.-H., Jen, I.-A., Chen, M., Lan, Y.-C., Liu, Y.-L., Lee, Y., Chen, Y.-H., Chen, Y.-M. A. Tags: Immunology (including allergy), Muscle disease, Ophthalmology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Systemic lupus erythematosus Clinical and epidemiological research Source Type: research

Rheumatoid arthritis phenotype at presentation differs depending on the number of autoantibodies present
Conclusions The number of autoantibodies, reflecting the breadth of the humoral autoimmune response, is associated with the clinical presentation of RA. Predisease pathophysiology is thus reflected by the initial clinical phenotype.
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Derksen, V. F. A. M., Ajeganova, S., Trouw, L. A., van der Helm-van Mil, A. H. M., Hafström, I., Huizinga, T. W. J., Toes, R. E. M., Svensson, B., van der Woude, D. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE
Conclusions ROCK activity is elevated in PBMCs from patients with SLE and RA. Production of IL-17 and IL-21 by SLE T cells or Th17 cells can furthermore be inhibited by targeting the RhoA-ROCK pathway via both non-selective and selective approaches.
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Rozo, C., Chinenov, Y., Maharaj, R. K., Gupta, S., Leuenberger, L., Kirou, K. A., Bykerk, V. P., Goodman, S. M., Salmon, J. E., Pernis, A. B. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Systemic lupus erythematosus Basic and translational research Source Type: research

TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis
Conclusions Using an innovative antigen-agnostic approach, we uncovered a population of bona fide synovial Treg cells readily accessible from the blood and selectively expanding during active disease, paving the way to non-invasive diagnostics and better understanding of the pathogenesis of autoimmunity.
Source: Annals of the Rheumatic Diseases - January 9, 2017 Category: Rheumatology Authors: Rossetti, M., Spreafico, R., Consolaro, A., Leong, J. Y., Chua, C., Massa, M., Saidin, S., Magni-Manzoni, S., Arkachaisri, T., Wallace, C. A., Gattorno, M., Martini, A., Lovell, D. J., Albani, S. Tags: Open access, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis
Conclusions This study reveals a potential role for MAIT cells in patients with AS and is the first linking IL-7 to the elevated IL-17 profile in patients through the AS-associated risk gene IL7R.
Source: Annals of the Rheumatic Diseases - November 9, 2016 Category: Rheumatology Authors: Gracey, E., Qaiyum, Z., Almaghlouth, I., Lawson, D., Karki, S., Avvaru, N., Zhang, Z., Yao, Y., Ranganathan, V., Baglaenko, Y., Inman, R. D. Tags: Genetics, Immunology (including allergy), Inflammation, Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Basic and translational research Source Type: research

Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis
Conclusions These findings indicate that simultaneous activation of all three PPAR isoforms exerts a dampening effect on inflammation and fibrosis, making IVA337 a potentially effective therapeutic candidate in the treatment of fibrotic diseases including SSc.
Source: Annals of the Rheumatic Diseases - November 9, 2016 Category: Rheumatology Authors: Ruzehaji, N., Frantz, C., Ponsoye, M., Avouac, J., Pezet, S., Guilbert, T., Luccarini, J.-M., Broqua, P., Junien, J.-L., Allanore, Y. Tags: Open access, Immunology (including allergy), Inflammation, Connective tissue disease Basic and translational research Source Type: research

Parental rheumatoid arthritis and long-term child morbidity: a nationwide cohort study
Conclusions were roughly similar for children exposed to maternal clinical RA and for children only followed up to 16 years of age. Conclusion Children of parents with RA had consistent excess morbidity. If the associations reflect biological mechanisms, genetic factors seem to play an important role. These findings call for attention given to children of parents with RA.
Source: Annals of the Rheumatic Diseases - September 8, 2016 Category: Rheumatology Authors: Rom, A. L., Wu, C. S., Olsen, J., Jawaheer, D., Hetland, M. L., Ottesen, B., Morch, L. S. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research

Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs
Conclusion We provided novel evidence that B cells differentiated within synovial ELS in the RA joints frequent target deiminated proteins which could be generated during NETosis of RA synovial neutrophils including histones. Thus, NETs could represent a source of citrullinated antigens fuelling the ACPA autoimmune response within the RA synovium.
Source: Annals of the Rheumatic Diseases - September 8, 2016 Category: Rheumatology Authors: Corsiero, E., Bombardieri, M., Carlotti, E., Pratesi, F., Robinson, W., Migliorini, P., Pitzalis, C. Tags: Open access, Genetics, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS)
Conclusions Childhood cancer survivors are at increased risk for certain types of autoimmune diseases. These findings underscore the need for prolonged follow-up of these survivors.
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Holmqvist, A. S., Olsen, J. H., Mellemkjaer, L., Garwicz, S., Hjorth, L., Moëll, C., Mansson, B., Tryggvadottir, L., Hasle, H., Winther, J. F., on behalf of the ALiCCS study group Tags: Press releases, Immunology (including allergy), Renal medicine, Vascularitis, Health economics Clinical and epidemiological research Source Type: research

Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway
Conclusions We report for the first time the association of TYK2 with SSc and reinforce the relevance of the IL-12 pathway in SSc pathophysiology.
Source: Annals of the Rheumatic Diseases - July 7, 2016 Category: Rheumatology Authors: Lopez-Isac, E., Campillo-Davo, D., Bossini-Castillo, L., Guerra, S. G., Assassi, S., Simeon, C. P., Carreira, P., Ortego-Centeno, N., Garcia de la Pena, P., the Spanish Scleroderma Group, Beretta, L., Santaniello, A., Bellocchi, C., Lunardi, C., Moroncini Tags: Genetics, Immunology (including allergy), Connective tissue disease, Epidemiology Basic and translational research Source Type: research

MicroRNA markers of inflammation and remodelling in temporal arteries from patients with giant cell arteritis
Conclusions MiR-146b-5p, -146a, -21, -150, -155, -299-5p are overexpressed in the presence of inflammation in TABs from patients with GCA.
Source: Annals of the Rheumatic Diseases - July 7, 2016 Category: Rheumatology Authors: Croci, S., Zerbini, A., Boiardi, L., Muratore, F., Bisagni, A., Nicoli, D., Farnetti, E., Pazzola, G., Cimino, L., Moramarco, A., Cavazza, A., Casali, B., Parmeggiani, M., Salvarani, C. Tags: Immunology (including allergy), Pathology, Inflammation, Radiology, Vascularitis, Surgical diagnostic tests, Clinical diagnostic tests Basic and translational research Source Type: research

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups
Conclusions This work represents the largest IIM genetic study to date, reveals new insights into the genetic architecture of these rare diseases and suggests different predominating pathophysiology in different clinical subgroups.
Source: Annals of the Rheumatic Diseases - July 7, 2016 Category: Rheumatology Authors: Rothwell, S., Cooper, R. G., Lundberg, I. E., Miller, F. W., Gregersen, P. K., Bowes, J., Vencovsky, J., Danko, K., Limaye, V., Selva-O'Callaghan, A., Hanna, M. G., Machado, P. M., Pachman, L. M., Reed, A. M., Rider, L. G., Cobb, J., Platt, H., Molberg, O Tags: Genetics, Immunology (including allergy), Muscle disease, Interstitial lung disease, Connective tissue disease, Musculoskeletal syndromes Basic and translational research Source Type: research

Outcomes of percutaneous coronary intervention in patients with rheumatoid arthritis and systemic lupus erythematosus: an 11-year nationwide cohort study
Conclusions This study recognises the inherent risks associated with RA and SLE in patients undergoing PCI and highlights the necessity to improve the caring and secondary prevention strategies for these high-risk patients.
Source: Annals of the Rheumatic Diseases - June 9, 2016 Category: Rheumatology Authors: Lai, C.-H., Lai, W.-W., Chiou, M.-J., Lin, W.-C., Yang, Y.-J., Li, C.-Y., Tsai, L.-M. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Systemic lupus erythematosus, Epidemiology Clinical and epidemiological research Source Type: research

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus
Conclusions Treg defects in patients with SLE are associated with IL-2 deficiency, and can be corrected with low doses of IL-2. The restoration of endogenous mechanisms of immune tolerance by low-dose IL-2 therapy, thus, proposes a selective biological treatment strategy, which directly addresses the pathophysiology in SLE.
Source: Annals of the Rheumatic Diseases - June 9, 2016 Category: Rheumatology Authors: von Spee-Mayer, C., Siegert, E., Abdirama, D., Rose, A., Klaus, A., Alexander, T., Enghard, P., Sawitzki, B., Hiepe, F., Radbruch, A., Burmester, G.-R., Riemekasten, G., Humrich, J. Y. Tags: Immunology (including allergy), Connective tissue disease, Systemic lupus erythematosus Basic and translational research Source Type: research

PUF60: a prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome
Conclusions PUF60 represents a novel autoantigen in patients with SS and DM. PUF60 antibodies are associated with distinct clinical features and different immune responses in different diseases.
Source: Annals of the Rheumatic Diseases - May 9, 2016 Category: Rheumatology Authors: Fiorentino, D. F., Presby, M., Baer, A. N., Petri, M., Rieger, K. E., Soloski, M., Rosen, A., Mammen, A. L., Christopher-Stine, L., Casciola-Rosen, L. Tags: Immunology (including allergy), Muscle disease, Connective tissue disease, Musculoskeletal syndromes, Systemic lupus erythematosus Clinical and epidemiological research Source Type: research

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