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MELAS Syndrome: How Stroke-like are the Stroke episodes? (P1.255)
Conclusions:Patients with MELAS syndrome may present with recurrent strokes in the arterial territory rather than SLEs. Clinicians should entertain the possibility of a mitochondrial disease in young patients with cryptogenic stroke and pursue appropriate diagnostic evaluations and treatment.Disclosure: Dr. Liaw has nothing to disclose. Dr. Lewis has nothing to disclose. Dr. Saini has nothing to disclose. Dr. Gultekin has nothing to disclose. Dr. Koch has nothing to disclose. Dr. Asdaghi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Liaw, N., Lewis, R., Saini, V., Gultekin, S. H., Koch, S., Asdaghi, N. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Ischemic stroke in a patient with Parry-Romberg syndrome (P4.064)
Conclusions:The only other reported patient with PRS and stroke was also found to have a PFO. It is possible that the elevated ANA seen in this patient correlates with propensity towards small venous clots not seen on ultrasound. This may lead to paradoxical emboli and ischemic strokes. It is important to note this potential association between PRS and ischemic stroke in young patients without other known risk factors. It would be worthwhile to treat this subset of patients with medications for secondary stroke prevention.Disclosure: Dr. Ebiana has nothing to disclose. Dr. Singh has nothing to disclose. Dr. Khosa has nothi...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ebiana, V., Singh, S., Khosa, S., Moheb, N., Trikamji, B., Rao, N., Mishra, S. Tags: General Neurology: Vascular Neurology Source Type: research

Evaluation of Clinico-radiological, Molecular and Histological Diagnosis of m.3243A>G-related MELAS Syndrome (P2.259)
CONCLUSIONS: Our data suggest that SLE phenomenology is much more uniform than purported in the literature. These findings highlights the importance of a comprehensive clinical examination including detailed visual field evaluation and consideration of m.3243A>G in all cases of stroke and encephalopathy irrespective of age, gender or family pedigree with an unrecognised high recurrence rate within first year of initial presentation. Aggressive mangement of seizure is advocated to prevent ensuing SLE. Study Supported by:Disclosure: Dr. Ng has nothing to disclose. Dr. Gorman has nothing to disclose. Dr. Schaefer has nothi...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ng, Y. S., Gorman, G., Schaefer, A., Taylor, R., McFarland, R., Turnbull, D. Tags: Cerebrovascular Disease and Interventional Neurology: Genetics and Stroke Source Type: research

Sleep duration is associated with worse neurocognitive function in Hispanic/Latinos: Results of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (I9-4A)
CONCLUSIONS: Sleep duration had an inverted J-shaped curvilinear association with neurocognitive function, such that those with longer sleep duration had worse neurocognitive scores. Study Supported by: The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Cent...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ramos, A., Tarraf, W., Daviglus, M., Davis, S., Gallo, L., Mossavar-Rahmani, Y., Penedo, F., Redline, S., Rundek, T., Sacco, R., Sotres-Alvarez, D., Wright, C., Zee, P., Gonzalez, H. Tags: Treating Dementia in an Age of Mixed Disease Data Blitz Presentations Source Type: research

Sleep duration is associated with worse neurocognitive function in Hispanic/Latinos: Results of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (P1.100)
CONCLUSIONS: Sleep duration had an inverted J-shaped curvilinear association with neurocognitive function, such that those with longer sleep duration had worse neurocognitive scores. Study Supported by: The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Cent...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ramos, A., Tarraf, W., Daviglus, M., Davis, S., Gallo, L., Mossavar-Rahmani, Y., Penedo, F., Redline, S., Rundek, T., Sacco, R., Sotres-Alvarez, D., Wright, C., Zee, P., Gonzalez, H. Tags: Neuroepidemiology: Cerebrovascular Disease, Critical Care, Epilepsy, Child Neurology, and Sleep Source Type: research

Teaching NeuroImages: Superficial siderosis due to a dural cervical arteriovenous fistula
A 58-year-old man presented to our hospital with cerebellar ataxia, pyramidal signs, dysarthria, bilateral deafness, and cognitive impairment. These symptoms were consistent with superficial siderosis (SS) of the CNS, confirmed by MRI (figure A).1 Cerebral angiography showed a dural arteriovenous fistula perispinal and pontic with venous drainage in the left foramen C1-C2, fed by meningeal branches of the vertebral artery (figure, B). The fistulous point was clipped. SS of CNS is a rare disease resulting from hemosiderin deposition on the surface of the CNS and cranial nerves.2 At diagnosis, the etiology may...
Source: Neurology - February 19, 2017 Category: Neurology Authors: Madkouri, R., Grelat, M. Tags: All Cerebrovascular disease/Stroke, All Spinal Cord, Arteriovenous malformation, Subarachnoid hemorrhage RESIDENT AND FELLOW SECTION Source Type: research