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Specialty: Urology & Nephrology
Source: Current Opinion in Nephrology and Hypertension
Condition: Pulmonary Hypertension

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Total 2 results found since Jan 2013.

PPARγ is a gatekeeper for extracellular matrix and vascular cell homeostasis: beneficial role in pulmonary hypertension and renal/cardiac/pulmonary fibrosis
Purpose of review Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial cell (PAEC) dysfunction and apoptosis, pulmonary arterial smooth muscle cell (PASMC) proliferation, inflammation, vasoconstriction, and metabolic disturbances that include disrupted bone morphogenetic protein receptor (BMPR2)-peroxisome proliferator-activated receptor gamma (PPARγ) axis and DNA damage. Activation of PPARγ improves many of these mechanisms, although erroneous reports on potential adverse effects of thiazolidinedione (TZD)-class PPARγ agonists reduced their clinical use in the past decade. Here, we...
Source: Current Opinion in Nephrology and Hypertension - January 30, 2020 Category: Urology & Nephrology Tags: PATHOPHYSIOLOGY OF HYPERTENSION: Edited by Nancy J. Brown Source Type: research

Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation
Purpose of review: Angiotensin converting enzyme 2 (ACE2) is an important regulator of the renin–angiotensin system through actions to degrade angiotensin II. Loss of ACE2 can contribute to the development and progression of cardiovascular disease, and experimental studies have highlighted a beneficial role for novel therapeutic approaches that activate or replenish tissue ACE2. This review focuses on experimental studies that have used the off-target effects of the antitrypanosomal agent, diminazene aceturate (DIZE) to activate ACE2. Recent findings: In cardiovascular disease, activation of the classical renin–angiot...
Source: Current Opinion in Nephrology and Hypertension - August 5, 2016 Category: Urology & Nephrology Tags: PHARMACOLOGY AND THERAPEUTICS: Edited by Adam Whaley-Connell and Sankar D. Navaneethan Source Type: research