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Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome
Publication date: Available online 26 October 2015 Source:Trends in Pharmacological Sciences Author(s): Nader G. Abraham, Joshua M. Junge, George S. Drummond The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic syndrome. This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2, biliverdin reductase, and HO activity on vascular disease. The HO system engages with other systems to mitigate the deleterious effects of oxidative stress in obesity and cardiovascular disease (CVD). Recent reports indicate that HO-1/HO-2 prote...
Source: Trends in Pharmacological Sciences - October 27, 2015 Category: Drugs & Pharmacology Source Type: research