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SANGUINATE (PEGylated Carboxyhemoglobin Bovine): Mechanism of Action and Clinical Update
Abstract Historically, blood substitutes were under development that would provide oxygen carrying capacity as well as fluid replacement for both trauma and surgical indications. Their development was halted by the inability of the products to deliver therapeutic amounts of oxygen targeted to hypoxic tissue as well as from the inherent toxicity of the molecules. This led to the concept of an oxygen therapeutic that would be targeted for indications caused by anemia/ischemia/hypoxia but would not exhibit the toxicity that plagued earlier products. The complex pathophysiology of diseases such as sickle cell and hemorrhagic s...
Source: Artificial Organs - April 11, 2017 Category: Transplant Surgery Authors: Abraham Abuchowski Tags: Main Text Article Source Type: research