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Cancer: Colon Cancer
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Total 16 results found since Jan 2013.
Higher Order Chromatin Structure of the Gel-forming Mucin Gene Gene Regulation
Four of the genes that encode gel-forming mucins, which are major components of the mucus layer protecting many epithelial surfaces, are clustered at chromosome 11p15.5 and show both cell- and tissue-specific expression patterns. We aimed to determine whether the individual genes were coordinately regulated by mechanisms involving higher order chromatin structure. CCCTC-binding factor (CTCF) sites were predicted in silico and CTCF occupancy then evaluated by chromatin immunoprecipitation. CTCF was found at many sites across the gene cluster, and its binding was correlated with mucin gene expression. Next, siRNA-mediated de...
Source: Journal of Biological Chemistry - March 1, 2013 Category: Chemistry Authors: Gosalia, N., Leir, S.-H., Harris, A. Tags: Glycobiology and Extracellular Matrices Source Type: research
