Filtered By:
Source: Cancer Research
Cancer: Colon Cancer

This page shows you your search results in order of date. This is page number 4.

Order by Relevance | Date

Total 53 results found since Jan 2013.

Abstract 5358: IL-4/IL-13 induce Duox2/DuoxA2 expression and reactive oxygen production in human pancreatic and colon cancer cells
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) contribute significantly to inflammation-associated carcinogenesis. Expression of dual oxidase 2 (Duox2), one of seven members of the NOX gene family, is up-regulated in inflammatory bowel disease, chronic pancreatitis, and in many human malignancies including carcinomas of the prostate, lung, and breast. Previously, we demonstrated that Stat1 and/or NF-κB play a critical role in modulating the enhanced expression of Duox2, and its cognate maturation factor DuoxA2, by IFN-γ and lipopolysaccharide in human pancreatic cancer cells. This cytokine-mediated increase in...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wu, Y., Doroshow, J. H. Tags: Carcinogenesis Source Type: research

Abstract 5362: Deficiencies in mismatch repair proteins induce elevated levels of acrolein-derived 1,N2-propanodeoxyguanosine and apoptosis in human colon cancer cells treated with acrolein
This study shows that MMR proteins, MLH1 and MSH2, are involved in the repair of Acr-dG. The results also suggest that Acr-dG may cause double-strand breaks which lead to apoptosis. Whether MMR acts as an independent repair pathway for Acr-dG or MMR proteins cross-talk and interact with other DNA repair pathways, such as NER, is under investigation. (Supported by NCI grant CA43159) Citation Format: Jishen Pan, Zhuoli Xuan, Marcin Dyba, Yongwei Zhang, Ying Fu, Rabindra Roy, Louis M. Weiner, Fung-Lung Chung. Deficiencies in mismatch repair proteins induce elevated levels of acrolein-derived 1,N2-propanodeoxyguanosine and apo...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Pan, J., Xuan, Z., Dyba, M., Zhang, Y., Fu, Y., Roy, R., Weiner, L. M., Chung, F.-L. Tags: Carcinogenesis Source Type: research

Abstract 5382: A breakthrough in application of a drug delivery nanoparticle system for therapy and diagnosis of solid tumor
Conclusion: Our data suggest that sCA itself, while designed as an in vivo delivery device, can facilitate entrance of low molecular chemicals into tumor cells in vitro and in vivo. Citation Format: Xin Wu, Hirofumi Yamamoto, Mamoru Uemura, Taishi Hata, Junichi Nishimura, Ichiro Takemasa, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori. A breakthrough in application of a drug delivery nanoparticle system for therapy and diagnosis of solid tumor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wu, X., Yamamoto, H., Uemura, M., Hata, T., Nishimura, J., Takemasa, I., Mizushima, T., Doki, Y., Mori, M. Tags: Cancer Chemistry Source Type: research

Abstract 5455: Resistance to a MEK inhibitor (AZD6244): Its association with increased expression of transcription factor 4
The important role of Ras/Raf/MEK/ERK pathway in carcinogenesis has led to clinical development of MEK inhibitors for treatment of various cancers. Although recent studies have demonstrated impressive antitumor activities of the agents, many tumors show intrinsic and acquired resistance to MEK inhibitors. We tried to find biomarkers that were associated with intrinsic or acquired resistance to a MEK inhibitor (AZD6244) by public microarray data acquisition and development of AZD6244-resistance cell lines. First, we analyzed a set of genome-wide gene expression profiling data from 6 sensitive and 6 resistant cell lines of v...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Goo, B.-K., Hur, E.-H., Choi, Y., Kim, S.-D., Hwang, J. J., Kim, C.-S., Bae, K. S., Choi, J., Cho, S. Y., Yang, S.-H., Lee, J.-H. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 5204: MicroRNA-6734 induces p21 gene expression by targeting a complementary p21 promoter sequence and inhibits colon cancer cells
MicroRNAs (miRNAs) regulate gene expression by binding to the cellular transcript leading to translational repression or degradation of the target mRNA. However, miRNA have also been shown to induce gene expression by targeting promoter in a phenomenon referred to as RNA activation (RNAa). Recently, p21 promoter targeted small activating RNA, dsP21-322, has been shown to inhibit the growth of various cancer cells. The purpose of this study was to investigate the effects of miR-6734, which has a sequence homology with dsP21-322, on p21 gene activation and cell growth inhibition in HCT116 human colon cancer cells. miR-6734 i...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Kang, M. R., Yun, J., Oh, S. J., Lee, C. W., Park, K. H., Kang, J. S. Tags: Molecular and Cellular Biology Source Type: research

Effects of DCLK1-siRNA{+/-}Curcumin on Cancer Stem Cells
Curcumin is known to induce apoptosis of cancer cells by different mechanisms, but its effects on cancer stem cells (CSC) have been less investigated. Here, we report that curcumin promotes the survival of DCLK1-positive colon CSCs, potentially confounding application of its anticancer properties. At optimal concentrations, curcumin greatly reduced expression levels of stem cell markers (DCLK1/CD44/ALDHA1/Lgr5/Nanog) in three-dimensional spheroid cultures and tumor xenografts derived from colon cancer cells. However, curcumin unexpectedly induced proliferation and autophagic survival of a subset of DCLK1-positive CSCs. Sph...
Source: Cancer Research - April 30, 2014 Category: Cancer & Oncology Authors: Kantara, C., O'Connell, M., Sarkar, S., Moya, S., Ullrich, R., Singh, P. Tags: Prevention and Epidemiology Source Type: research

Adaptive Response Diminishes Therapeutic Effectiveness
Adaptive responses can be induced in cells by very low doses of ionizing radiation resulting in an enhanced resistance to much larger exposures. The inhibitor of apoptosis protein, survivin, has been implicated in many adaptive responses to cellular stress. Computerized axial tomography used in image-guided radiotherapy to position and monitor tumor response uses very low radiation doses ranging from 0.5 to 100 mGy. We investigated the ability of these very low radiation doses administered along with two 2 Gy doses separated by 24 hours, a standard conventional radiotherapy dosing schedule, to initiate adaptive responses r...
Source: Cancer Research - July 15, 2013 Category: Cancer & Oncology Authors: Grdina, D. J., Murley, J. S., Miller, R. C., Mauceri, H. J., Sutton, H. G., Li, J. J., Woloschak, G. E., Weichselbaum, R. R. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

MLN4924 Genome-Wide RNAi Screen
MLN4924 is an investigational small-molecule inhibitor of the NEDD8-activating enzyme (NAE) in phase I clinical trials. NAE inhibition prevents the ubiquitination and proteasomal degradation of substrates for cullin-RING ubiquitin E3 ligases that support cancer pathophysiology, but the genetic determinants conferring sensitivity to NAE inhibition are unknown. To address this gap in knowledge, we conducted a genome-wide siRNA screen to identify genes and pathways that affect the lethality of MLN4924 in melanoma cells. Of the 154 genes identified, approximately one-half interfered with components of the cell cycle, apoptotic...
Source: Cancer Research - January 2, 2013 Category: Cancer & Oncology Authors: Blank, J. L., Liu, X. J., Cosmopoulos, K., Bouck, D. C., Garcia, K., Bernard, H., Tayber, O., Hather, G., Liu, R., Narayanan, U., Milhollen, M. A., Lightcap, E. S. Tags: Molecular and Cellular Pathobiology Source Type: research