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Glutamate quantification in patients with supratentorial gliomas using chemical shift imaging
This study aimed to evaluate and validate chemical shift imaging (CSI) for in vivo glutamate (Glu) quantification in patients with supratentorial gliomas. If validated, CSI could become an extremely useful tool to investigate metabolic dysfunction of Glu in excitotoxic neuropathologies. Quantitative CSI estimates of Glu concentrations were compared with known concentrations of Glu in aqueous phantom solutions. Forty‐one patients with known or likely supratentorial gliomas underwent preoperative CSI. The spectra obtained were analyzed for Glu concentrations and Glu to creatine (Cr) ratios. These in vivo measurements were ...
Source: NMR in Biomedicine - March 24, 2014 Category: Radiology Authors: S. V. Liubinas, K. J. Drummond, P. M. Desmond, A. Bjorksten, A. P. Morokoff, A. H. Kaye, T. J. O'Brien, B. A. Moffat Tags: Research article Source Type: research

Technical considerations on the validity of blood oxygenation level‐dependent‐based MR assessment of vascular deoxygenation
A blood oxygenation level‐dependent (BOLD)‐based apparent relative oxygen extraction fraction (rOEF) as a semi‐quantitative marker of vascular deoxygenation has recently been introduced in clinical studies of patients with glioma and stroke, yielding promising results. These rOEF measurements are based on independent quantification of the transverse relaxation times T2 and T2* and relative cerebral blood volume (rCBV). Simulations demonstrate that small errors in any of the underlying measures may result in a large deviation of the calculated rOEF. Therefore, we investigated the validity of such measurements. For thi...
Source: NMR in Biomedicine - May 9, 2014 Category: Radiology Authors: Nuria M. Hirsch, Vivien Toth, Annette Förschler, Hendrik Kooijman, Claus Zimmer, Christine Preibisch Tags: Research article Source Type: research

How cost-effective is intraoperative MRI for gliomas?
Using a simulated clinical decision analysis model, researchers from the University...Read more on AuntMinnie.comRelated Reading: Workflow optimization cuts MRI turnaround time Imaging analytics platform optimizes MRI operations MRA is cost-effective for kidney disease-related aneurysms Study reveals steep cost of delaying stroke treatment MRI for knee pain adds cost with negligible benefit
Source: AuntMinnie.com Headlines - April 2, 2019 Category: Radiology Source Type: news