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Antiproliferative Effect of Synadenium grantii Hook f. stems (Euphorbiaceae) and a Rare Phorbol Diterpene Ester
Synadenium grantii is frequently used for the treatment of various diseases such as allergies, gastric disorders, and especially cancer. The aim of this study was to evaluate the possible antiproliferative potential of the methanol extract, fractions, and pure compounds from the stems of S grantii. Phytochemical analysis was carried out by conventional chromatographic techniques, and the antiproliferative activity was analyzed using the sulforhodamine B assay and an MTT-based assay. Nonpolar fraction and its subfractions from the stems of S grantii exhibited promising cytostatic effect against several human tumor cell line...
Source: International Journal of Toxicology - December 1, 2016 Category: Toxicology Authors: Campos, A., Vendramini-Costa, D. B., Longato, G. B., Zermiani, T., Ruiz, A. L. T. G., de Carvalho, J. E., Pandiella, A., Cechinel Filho, V. Tags: Regular Articles Source Type: research