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Cancer: Adenocarcinoma
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From Screening to Treatment of Pancreatic Cancer: A Comprehensive Review
We present an in-depth analysis of the phase I-III clinical trials determining the role and efficacy of different modalities. We also describe rationale for future investigation.DISCUSSION: Despite advances in first-line and second-line therapies for APC, median OS remains short of a year. We need collaborative efforts between the cooperative groups, institutions, community practices and industry to work together in enrolling these patients in clinical trials. In addition to use new technologies, such as organoids, we must pay attention to the palliative aspect of care for these patients from the beginning including nutrit...
Source: JOP - September 6, 2021 Category: Gastroenterology Authors: Muhammad Wasif Saif Source Type: research
High-throughput Single-cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma
Angew Chem Int Ed Engl. 2021 Sep 10. doi: 10.1002/anie.202107223. Online ahead of print.ABSTRACTEven populations of clonal cells are heterogeneous, which requires high-throughput analysis methods with single-cell sensitivity. Here, we propose a rapid, label-free single-cell analytical method based on active capillary dielectric barrier discharge ionization mass spectrometry, which can analyze multiple metabolites in single cells at a rate of 38 cells/minute. Multiple cell types (HEK-293T, PANC-1, CFPAC-1, H6c7, HeLa and iBAs) were discriminated successfully. We found that abnormal lipid metabolism occurs in pancreatic canc...
Source: Angewandte Chemie - September 10, 2021 Category: Chemistry Authors: Qinlei Liu Wenjie Ge Tongtong Wang Jiayi Lan Sandra Mart ínez-Jarquín Christian Wolfrum Markus Stoffel Renato Zenobi Source Type: research
From Screening to Treatment of Pancreatic Cancer: A Comprehensive Review
We present an in-depth analysis of the phase I-III clinical trials determining the role and efficacy of different modalities. We also describe rationale for future investigation.DISCUSSION: Despite advances in first-line and second-line therapies for APC, median OS remains short of a year. We need collaborative efforts between the cooperative groups, institutions, community practices and industry to work together in enrolling these patients in clinical trials. In addition to use new technologies, such as organoids, we must pay attention to the palliative aspect of care for these patients from the beginning including nutrit...
Source: JOP - September 6, 2021 Category: Gastroenterology Authors: Muhammad Wasif Saif Source Type: research
High-throughput Single-cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma
Angew Chem Int Ed Engl. 2021 Sep 10. doi: 10.1002/anie.202107223. Online ahead of print.ABSTRACTEven populations of clonal cells are heterogeneous, which requires high-throughput analysis methods with single-cell sensitivity. Here, we propose a rapid, label-free single-cell analytical method based on active capillary dielectric barrier discharge ionization mass spectrometry, which can analyze multiple metabolites in single cells at a rate of 38 cells/minute. Multiple cell types (HEK-293T, PANC-1, CFPAC-1, H6c7, HeLa and iBAs) were discriminated successfully. We found that abnormal lipid metabolism occurs in pancreatic canc...
Source: Angewandte Chemie - September 10, 2021 Category: Chemistry Authors: Qinlei Liu Wenjie Ge Tongtong Wang Jiayi Lan Sandra Mart ínez-Jarquín Christian Wolfrum Markus Stoffel Renato Zenobi Source Type: research
From Screening to Treatment of Pancreatic Cancer: A Comprehensive Review
We present an in-depth analysis of the phase I-III clinical trials determining the role and efficacy of different modalities. We also describe rationale for future investigation.DISCUSSION: Despite advances in first-line and second-line therapies for APC, median OS remains short of a year. We need collaborative efforts between the cooperative groups, institutions, community practices and industry to work together in enrolling these patients in clinical trials. In addition to use new technologies, such as organoids, we must pay attention to the palliative aspect of care for these patients from the beginning including nutrit...
Source: JOP - September 6, 2021 Category: Gastroenterology Authors: Muhammad Wasif Saif Source Type: research
High-throughput Single-cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma
Angew Chem Int Ed Engl. 2021 Sep 10. doi: 10.1002/anie.202107223. Online ahead of print.ABSTRACTEven populations of clonal cells are heterogeneous, which requires high-throughput analysis methods with single-cell sensitivity. Here, we propose a rapid, label-free single-cell analytical method based on active capillary dielectric barrier discharge ionization mass spectrometry, which can analyze multiple metabolites in single cells at a rate of 38 cells/minute. Multiple cell types (HEK-293T, PANC-1, CFPAC-1, H6c7, HeLa and iBAs) were discriminated successfully. We found that abnormal lipid metabolism occurs in pancreatic canc...
Source: Angewandte Chemie - September 10, 2021 Category: Chemistry Authors: Qinlei Liu Wenjie Ge Tongtong Wang Jiayi Lan Sandra Mart ínez-Jarquín Christian Wolfrum Markus Stoffel Renato Zenobi Source Type: research
From Screening to Treatment of Pancreatic Cancer: A Comprehensive Review
We present an in-depth analysis of the phase I-III clinical trials determining the role and efficacy of different modalities. We also describe rationale for future investigation.DISCUSSION: Despite advances in first-line and second-line therapies for APC, median OS remains short of a year. We need collaborative efforts between the cooperative groups, institutions, community practices and industry to work together in enrolling these patients in clinical trials. In addition to use new technologies, such as organoids, we must pay attention to the palliative aspect of care for these patients from the beginning including nutrit...
Source: JOP - September 6, 2021 Category: Gastroenterology Authors: Muhammad Wasif Saif Source Type: research
