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Source: Cancer Research
Cancer: Squamous Cell Carcinoma
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Total 42 results found since Jan 2013.
Abstract 5466: Integrative TCGA analyses identify Basonuclin1 (BNC1) as a key mediator for platinum resistance
Conclusion. Collectively, BNC1 represents an important target for enhancing platinum-sensitivity in ovarian and lung cancer. Targeting BNC1 in platinum-resistant malignancies may improve patient survival.Note: This abstract was not presented at the meeting.Citation Format: Sherry Y. Wu, Justyna Filant, Michael McGuire, Rajesha Rupaimoole, Sunila Pradeep, Anna Unruh, Herbrich Shelley, Cristina Ivan, Ruder Dennis, Cristian Rodriguez-Aguayo, Vasudha Sehgal, Takahito Miyake, Archana Nagaraja, Kshipra Gharpure, Guillermo Armaiz, Rebecca Previs, Gabriel Lopez-Berestein, Prahlad Ram, Keith Baggerly, Anil Sood. Integrative TCGA an...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Wu, S. Y., Filant, J., McGuire, M., Rupaimoole, R., Pradeep, S., Unruh, A., Shelley, H., Ivan, C., Dennis, R., Rodriguez-Aguayo, C., Sehgal, V., Miyake, T., Nagaraja, A., Gharpure, K., Armaiz, G., Previs, R., Lopez-Berestein, G., Ram, P., Baggerly, K., So Tags: Experimental and Molecular Therapeutics Source Type: research
Abstract 5474: PD-L1 regulates cisplatin chemoresistance in head and neck squamous cell carcinoma
In conclusion, we have identified a novel role for PD-L1 in the development of chemoresistance through its interaction with the MRN complex, which plays a major role in the repair of chemo-induced DNA DSB. Therapies aimed at blocking PD-L1 show great promise because of their ability to enhance both chemotherapeutics and the anti-tumor immune response.Citation Format: Randall S. Ruffner, Andrew Ramsey, Bert W. O'Malley, Daqing Li. PD-L1 regulates cisplatin chemoresistance in head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Ap...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Ruffner, R. S., Ramsey, A., O'Malley, B. W., Li, D. Tags: Experimental and Molecular Therapeutics Source Type: research
Abstract 3776: HnRNP A1 regulates cell cycle and proliferation in oral squamous cancer cells
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in human head and neck neoplasms. Despite the improvement of therapeutic approaches, reducing high mortality is still the major challenge of OSCC. However, the molecular pathogenesis of OSCC remains largely unclear, which hinders the development of effective preventive and therapeutic methods. Alternative splicing of pre-mRNA has been implicated to be involved in tumorigenesis. Splicing factors play key roles in the regulation of alternative splicing. HnRNP A1 is an important multi-function splicing factor and closely related to tumorigenesis. It has be...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Yu, C., Guo, J., Jia, J., Jia, R., Fan, M. Tags: Molecular and Cellular Biology Source Type: research
Abstract 3793: Overexpression of A20 and activated-Src result in TRAIL resistance in oral cancer cells
In this study, we have used oral squamous cell carcinoma cell lines with and without distinct metastatic ability, and revealed the relationship between their anoikis and apoptosis sensitivity and the metastatic ability. At first we examined their sensitivity to anoikis by using the low attachment culture condition. There was no apparent relation between their metastatic potential and the sensitivity to anoikis. SAS cells which have no metastatic potency showed modest sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), whereas SAS-T5 cells and SAS-L1 cells, a clone with high metastatic potential ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Hino, S., Hamakawa, T., Nakashiro, K.-i., Hamakawa, H. Tags: Molecular and Cellular Biology Source Type: research
Abstract 4142: A role for apolipoprotein E in invasion in oral squamous cell carcinoma
Oral squamous cell carcinomas (OSCC) have a poor patient prognosis, which is attributed to their invasive nature. Our goal was to identify a novel gene that is important in OSCC invasion. We utilized genome-wide expression data generated from OSCC patient tumor samples with varying degrees of invasiveness, as measured by the histological parameter worst pattern of invasion (WPOI). RNA extracted from tumors that were classified as either WPOI 5 or WPOI 3, two categories of tumors that have been previously shown to correlate with local recurrence and poor overall survival, were evaluated utilizing two microarray platforms. W...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Jayakar, S. K., Loudig, O. D., Brandwein-Gensler, M., Kim, R., Ow, T. J., Prystowsky, M. B., Childs, G., Segall, J. E., Belbin, T. J. Tags: Tumor Biology Source Type: research
Abstract LB-215: The TAM family of receptor tyrosine kinases play a role in acquired resistance to cetuximab
Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that has shown efficacy in metastatic colorectal cancer, head and neck squamous cell carcinoma (HNSCC) and non-small cell lung cancer (NSCLC). Clinical data suggests that patients whom initially respond to cetuximab eventually acquire resistance, highlighting the importance of understanding resistant mechanisms for the development of better treatment regimes for cancer patients. Recent studies have identified a role for the TAM family of receptor tyrosine kinases (Tyro, Axl, and Mer) in tumor biology, and more specifically the Axl receptor as ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Brand, T. M., Iida, M., Corrigan, K. L., Luthar, N., Hornung, M., Toulany, M., Gill, P., Salgia, R., Wheeler, D. L. Tags: Experimental and Molecular Therapeutics Source Type: research
Abstract 1310: Increased cytoplasmic CDC25A phosphatase in cutaneous squamous cell carcinoma leads to 14-3-3 relocalization and suppression of apoptosis
Non-melanoma skin cancer, the most common cancer in the United States, frequently results from chronic exposure to ultraviolet (UV) irradiation. UV-induced DNA damage activates cell cycle arrest checkpoints through degradation of the cyclin-dependent kinase activators, the Cell Division Cycle 25 (CDC25) phosphatases, which are over-expressed and, thus, deregulate cell cycle control in many human cancers. To investigate a role for CDC25 in skin cancer, CDC25 levels were examined in both UV-induced mouse tumors and human skin cancer. CDC25A and CDC25C protein and transcripts were increased in benign and malignant skin tumors...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Almatouq, J., Ho, K., Hansen, L. A. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2350: Inhibition of Gli1 as a novel therapeutic target for lung squamous cell carcinoma
Conclusions: Our data suggest that Hh pathway downstream factor Gli1 expression is essential for cell proliferation and colony formation in lung SCC. Gli1 is not regulated by canonical Hh pathway regulators, whereas PI3K, ERK, and TGF pathways are involved in its regulation. Blocking Gli1 function is a novel therapeutic strategy for lung SCC treatment.
Citation Format: Chunli Shao. Inhibition of Gli1 as a novel therapeutic target for lung squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Can...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Shao, C. Tags: Molecular and Cellular Biology Source Type: research
Abstract 596: DKK3 expression and its function in head and neck squamous cell carcinoma
In this study, 90 cases of HNSCC tissue samples, which were obtained from Okayama University hospital with written informed consent, for immunohistochemistry to examine DKK3 protein expression. The protein expression status was scored as positive or negative. Pearson's Chi-square test and Fisher's exact test were used to evaluate the correlation between the DKK3 protein expression and clinicopathological characteristics. Kaplan-Meier analysis was performed to determine the survival analysis. For functional analyses, HNSCC-derived cells were used. Gastric and colorectal cancer cell lines were also used for comparison. DKK3 ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Katase, N., Gunduz, M., Tsujigiwa, H., Ito, S., Fujii, M., Nagatsuka, H., Sasaki, A., Nohno, T. Tags: Molecular and Cellular Biology Source Type: research
Abstract 1925: CK2 phosphorylates and inhibits tumor suppressor TAp73 function to promote cancer stem cell gene expression and phenotype in head and neck cancer
Cancer development, cell survival, and therapeutic resistance have recently been linked to a small sub-population of cells expressing stem cell genes, and capable of reproducing the cancer cell population, called cancer stem cells (CSC). CK2 (formerly casein kinase II) has emerged as a key signal serine/threonine kinase that modulates diverse signal cascades that regulate cell fate and growth. We previously showed that CK2 is aberrantly expressed and activated in head and neck squamous cell carcinomas (HNSCC). Concomitant inactivation of tumor suppressor TAp73, along with mutation of related family member TP53, is also oft...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Lu, H., Yan, C. H., Bian, Y., Chen, Z., Waes, C. V. Tags: Tumor Biology Source Type: research
Abstract 38: Quantitative proteomic approaches to identify biomarkers for oral cancer & targeting S100A7 by RNA-mediated interference through NF kappa beta-mediated pathway
Oral cancer is a leading cause of cancer death worldwide. The goal of cancer-screening program is to detect tumours at early stage. Moreover the screening tool must be sufficiently non invasive and inexpensive to allow widespread applicability.Protein biomarker discovery for early detection of head and neck squamous cell carcinoma (HNSCC) is a crucial needs to improve patient outcomes. The proteins secreted from cancer tissues are an important molecules which play a vital role, involved in various biological processes related to cancer metastasis and progression which makes a tissue proteome a rich reservoir of potential b...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Dey, K. K., Mandal, M. Tags: Tumor Biology Source Type: research
Abstract 2225: Comprehensive molecular characterization of esophageal squamous cell carcinoma
Conclusions
By demonstrating the genomic landscape of over 180 ESCC cases, our integrated study unmasks a number of novel genetic lesions in ESCC and provides an important molecular foundation for understanding esophageal tumors and developing therapeutic targets.
Citation Format: Dechen Lin, Xuan Meng, Liang Xu, Lingwen Ding, Manoj Garg, Henry Yang, Lizhen Liu, Jiajie Hao, Mingrong Wang, Yasunobu Nagata, Yusuke Sato, Yusuke Okuno, Seishi Ogawa, Phillip Koeffler. Comprehensive molecular characterization of esophageal squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Associatio...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Lin, D., Meng, X., Xu, L., Ding, L., Garg, M., Yang, H., Liu, L., Hao, J., Wang, M., Nagata, Y., Sato, Y., Okuno, Y., Ogawa, S., Koeffler, P. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2269: Combination of erlotinib and epigallocatechin-3-gallate induces apoptosis of squamous cell carcinoma of the head and neck through posttranslational regulation of Bim and Bcl-2
Conclusion: Our results strongly suggest that the combination of erlotinib and EGCG induces apoptosis of SCCHN cells by regulating Bim and Bcl-2 at the post-translational level. Currently, a clinical trial is underway at Winship Cancer Institute of Emory University to inhibit or reverse the progression of oral premalignant lesions using this combination. (This study is supported by R03CA159369, P50CA128613 and Robbins Scholar Award of Winship Cancer Institute).
Citation Format: Abedul Haque, Mohammad A. Rahman, Zhuo G. Chen, Dong M. Shin, A.R.M. Ruhul Amin. Combination of erlotinib and epigallocatechin-3-gallate induces ap...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Haque, A., Rahman, M. A., Chen, Z. G., Shin, D. M., Amin, A. R. M. R. Tags: Molecular and Cellular Biology Source Type: research
Abstract 316: Modifying autophagy through combination treatments as a potential therapeutic strategy in head and neck squamous cell carcinoma (HNSCC)
Discussion: Manipulating autophagy with Akt inhibition (induction) and Paclitaxel (decreasing autophagic trafficking) leads to an accumulation of autophagosomes and eventual cell death in a synergistic manner. This therapeutic approach of altering the normal autophagic process warrants further investigation.
Citation Format: Omar G. Ahmed, Wen-Liang Kuo, Tai-Fen Wei, Jeannette S. Messer, Marina Sharifi, Madhavi Nagilla, Kay Macleod, Ezra E.W. Cohen. Modifying autophagy through combination treatments as a potential therapeutic strategy in head and neck squamous cell carcinoma (HNSCC). [abstract]. In: Proceedings of the 105t...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Ahmed, O. G., Kuo, W.-L., Wei, T.-F., Messer, J. S., Sharifi, M., Nagilla, M., Macleod, K., Cohen, E. E. W. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2091: Metastatic oral cancer cell adhesion to vascular and lymphatic endothelial cells is sialyl Lewis A/X-dependent
Conclusions: Elevated levels of sLeX in metastatic OSCC cells results from increased FUT3 expression. Metastatic OSCC cell binding to HuDMEC/HLEC is sLeA/X-mediated and may be a target for anti-metastasis therapy.
Citation Format: Ahmed Alkishi, Syed Ali Khurram, Martin Thornhill, Craig Murdoch. Metastatic oral cancer cell adhesion to vascular and lymphatic endothelial cells is sialyl Lewis A/X-dependent. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2091. doi:10.1158/1538-7445.AM2014-2091
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Alkishi, A., Khurram, S. A., Thornhill, M., Murdoch, C. Tags: Tumor Biology Source Type: research
