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The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors Signal Transduction
We previously reported that the cell cycle–related cyclin-dependent kinase 4–retinoblastoma (RB) transcriptional corepressor pathway is essential for stroke-induced cell death both in vitro and in vivo. However, how this signaling pathway induces cell death is unclear. Previously, we found that the cyclin-dependent kinase 4 pathway activates the pro-apoptotic transcriptional co-regulator Cited2 in vitro after DNA damage. In the present study, we report that Cited2 protein expression is also dramatically increased following stroke/ischemic insult. Critically, utilizing conditional knockout mice, we show that Cited2 is r...
Source: Journal of Biological Chemistry - May 23, 2019 Category: Chemistry Authors: Tianwen Huang, Yasmilde Rodriguez Gonzalez, Dianbo Qu, En Huang, Farzaneh Safarpour, Eugene Wang, Alvin Joselin, Doo Soon Im, Steve M. Callaghan, Wassamon Boonying, Lisa Julian, Sally L. Dunwoodie, Ruth S. Slack, David S. Park Tags: Molecular Bases of Disease Source Type: research