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Effect modification in network meta-analyses for relapsed/refractory multiple myeloma: systematic review and meta-analysis
Conclusions Based on the available evidence, effect modification appears to be sufficiently small that it can be neglected in adequately performed NMAs. NMAs can probably be relied on to provide estimates of HRs for OS and PFS in RRMM, subject to caveats discussed herein.
Source: BMJ Open - August 29, 2023 Category: General Medicine Authors: Rose, C. J., Ohm, I. K., Giske, L., Naess, G. E., Fretheim, A. Tags: Open access, Oncology Source Type: research

Effect of bortezomib on the treatment of multiple myeloma: a systematic review protocol
This study aims to assess the effects of bortezomib on the overall survival (OS), progression-free survival, overall response rate, time to next treatment, health-related quality of life, compliance, adverse events and treatment-related death in patients with MM. Methods and analysis We have performed a systematic review and meta-analysis and will include both randomised and non-randomised controlled studies where the effect of bortezomib was compared in similar or dissimilar background therapies in each arm. General and adaptive search strategies have been created for the following electronic health databases: Embase, Me...
Source: BMJ Open - June 28, 2022 Category: General Medicine Authors: Cantadori, L. O., Gaiolla, R. D., Nunes-Nogueira, V. d. S. Tags: Open access, Haematology (incl blood transfusion) Source Type: research

Multiple myeloma and physical activity: a scoping review
Conclusions The search identified that the literature surrounding multiple myeloma and physical activity is very limited. We encourage those designing new cohort studies to allow for future assessment of associations between physical activity and onset of multiple myeloma and smouldering multiple myeloma, as well as the potential role that physical activity plays in the progression from smouldering multiple myeloma to multiple myeloma. Second, we encourage the design and investigation of gender and treatment-specific physical activity interventions in patients with multiple myeloma. Finally, we highlight the need for more ...
Source: BMJ Open - November 27, 2015 Category: Journals (General) Authors: Smith, L., McCourt, O., Henrich, M., Paton, B., Yong, K., Wardle, J., Fisher, A. Tags: Open access, Oncology, Sports and exercise medicine Research Source Type: research