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Source: J Biochem Mol Biol
Cancer: Leukemia
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Total 1264 results found since Jan 2013.
Cell cycle regulation and induction of apoptosis by beta-carotene in U937 and HL-60 leukemia cells
J Biochem Mol Biol. 2007 Nov 30;40(6):1009-15. doi: 10.5483/bmbrep.2007.40.6.1009.ABSTRACTIn this communication, we report the efficacy of beta-carotene towards differentiation and apoptosis of leukemia cells. Dose (20 microM) and time dependence (12 h) tests of beta- carotene showed a higher magnitude of decrease (significance p < 0.05) in cell numbers and cell viability in HL-60 cells than U937 cells but not normal cell like Peripheral blood mononuclear cell (PBMC). Microscopical observation of beta-carotene treated cells showed a distinct pattern of morphological abnormalities with inclusion of apoptotic bodies in bo...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: K R Upadhyaya K S Radha H K Madhyastha Source Type: research
Induction of megakaryocytic differentiation in chronic myelogenous leukemia cell K562 by 3-hydrogenkwadaphnin
In this study, we report that 3-HK (12 nM) has the ability to cease proliferation, induce differentiation and apoptosis in chronic myelogenous leukemia (CML) K562 cell line. The treated cells lost erythroid properties and differentiated along the megakaryocytic lineage based on the morphological features apparent after Wright-Giemsa staining, DNA content analysis and the expression of cell surface marker glycoprotein IIb as analyzed by flow cytometry. Moreover, using Hoechst 33258 and Annexin V double staining indicated the occurrence of apoptosis among the treated cells. On the other hand, restoration of the depleted GTP ...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: Azadeh Meshkini Razieh Yazdanparast Source Type: research
Cell cycle regulation and induction of apoptosis by beta-carotene in U937 and HL-60 leukemia cells
J Biochem Mol Biol. 2007 Nov 30;40(6):1009-15. doi: 10.5483/bmbrep.2007.40.6.1009.ABSTRACTIn this communication, we report the efficacy of beta-carotene towards differentiation and apoptosis of leukemia cells. Dose (20 microM) and time dependence (12 h) tests of beta- carotene showed a higher magnitude of decrease (significance p < 0.05) in cell numbers and cell viability in HL-60 cells than U937 cells but not normal cell like Peripheral blood mononuclear cell (PBMC). Microscopical observation of beta-carotene treated cells showed a distinct pattern of morphological abnormalities with inclusion of apoptotic bodies in bo...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: K R Upadhyaya K S Radha H K Madhyastha Source Type: research
Induction of megakaryocytic differentiation in chronic myelogenous leukemia cell K562 by 3-hydrogenkwadaphnin
In this study, we report that 3-HK (12 nM) has the ability to cease proliferation, induce differentiation and apoptosis in chronic myelogenous leukemia (CML) K562 cell line. The treated cells lost erythroid properties and differentiated along the megakaryocytic lineage based on the morphological features apparent after Wright-Giemsa staining, DNA content analysis and the expression of cell surface marker glycoprotein IIb as analyzed by flow cytometry. Moreover, using Hoechst 33258 and Annexin V double staining indicated the occurrence of apoptosis among the treated cells. On the other hand, restoration of the depleted GTP ...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: Azadeh Meshkini Razieh Yazdanparast Source Type: research
Cell cycle regulation and induction of apoptosis by beta-carotene in U937 and HL-60 leukemia cells
J Biochem Mol Biol. 2007 Nov 30;40(6):1009-15. doi: 10.5483/bmbrep.2007.40.6.1009.ABSTRACTIn this communication, we report the efficacy of beta-carotene towards differentiation and apoptosis of leukemia cells. Dose (20 microM) and time dependence (12 h) tests of beta- carotene showed a higher magnitude of decrease (significance p < 0.05) in cell numbers and cell viability in HL-60 cells than U937 cells but not normal cell like Peripheral blood mononuclear cell (PBMC). Microscopical observation of beta-carotene treated cells showed a distinct pattern of morphological abnormalities with inclusion of apoptotic bodies in bo...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: K R Upadhyaya K S Radha H K Madhyastha Source Type: research
Induction of megakaryocytic differentiation in chronic myelogenous leukemia cell K562 by 3-hydrogenkwadaphnin
In this study, we report that 3-HK (12 nM) has the ability to cease proliferation, induce differentiation and apoptosis in chronic myelogenous leukemia (CML) K562 cell line. The treated cells lost erythroid properties and differentiated along the megakaryocytic lineage based on the morphological features apparent after Wright-Giemsa staining, DNA content analysis and the expression of cell surface marker glycoprotein IIb as analyzed by flow cytometry. Moreover, using Hoechst 33258 and Annexin V double staining indicated the occurrence of apoptosis among the treated cells. On the other hand, restoration of the depleted GTP ...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: Azadeh Meshkini Razieh Yazdanparast Source Type: research
Cell cycle regulation and induction of apoptosis by beta-carotene in U937 and HL-60 leukemia cells
J Biochem Mol Biol. 2007 Nov 30;40(6):1009-15. doi: 10.5483/bmbrep.2007.40.6.1009.ABSTRACTIn this communication, we report the efficacy of beta-carotene towards differentiation and apoptosis of leukemia cells. Dose (20 microM) and time dependence (12 h) tests of beta- carotene showed a higher magnitude of decrease (significance p < 0.05) in cell numbers and cell viability in HL-60 cells than U937 cells but not normal cell like Peripheral blood mononuclear cell (PBMC). Microscopical observation of beta-carotene treated cells showed a distinct pattern of morphological abnormalities with inclusion of apoptotic bodies in bo...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: K R Upadhyaya K S Radha H K Madhyastha Source Type: research
Induction of megakaryocytic differentiation in chronic myelogenous leukemia cell K562 by 3-hydrogenkwadaphnin
In this study, we report that 3-HK (12 nM) has the ability to cease proliferation, induce differentiation and apoptosis in chronic myelogenous leukemia (CML) K562 cell line. The treated cells lost erythroid properties and differentiated along the megakaryocytic lineage based on the morphological features apparent after Wright-Giemsa staining, DNA content analysis and the expression of cell surface marker glycoprotein IIb as analyzed by flow cytometry. Moreover, using Hoechst 33258 and Annexin V double staining indicated the occurrence of apoptosis among the treated cells. On the other hand, restoration of the depleted GTP ...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: Azadeh Meshkini Razieh Yazdanparast Source Type: research
