• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial.
Conclusion: The effects of CEE did not differ by BSO status in the overall cohort, but some findings varied by age. Among women with prior BSO, in those aged 70 years or older, CEE led to adverse effects during the treatment period, whereas women randomly assigned to CEE before age 60 seemed to derive mortality benefit over the long term. Primary Funding Source: The WHI program is funded by the National Heart, Lung, and Blood Institute; National Institutes of Health; and U.S. Department of Health and Human Services. Wyeth Ayerst donated the study drugs. PMID: 31499528 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 9, 2019 Category: Internal Medicine Authors: Manson JE, Aragaki AK, Bassuk SS, Chlebowski RT, Anderson GL, Rossouw JE, Howard BV, Thomson CA, Stefanick ML, Kaunitz AM, Crandall CJ, Eaton CB, Henderson VW, Liu S, Luo J, Rohan T, Shadyab AH, Wells G, Wactawski-Wende J, Prentice RL, WHI Investigators Tags: Ann Intern Med Source Type: research

Should This Patient Receive Aspirin?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2017 Dec 05;167(11):786-793 Authors: Burns RB, Graham K, Sawhney MS, Reynolds EE Abstract Aspirin exerts antiplatelet effects through irreversible inhibition of cyclooxygenase-1, whereas its anticancer effects may be due to inhibition of cyclooxygenase-2 and other pathways. In 2009, the U.S. Preventive Services Task Force endorsed aspirin for primary prevention of cardiovascular disease. However, aspirin's role in cancer prevention is still emerging, and no groups currently recommend its use for this purpose. To help physicians bala...
Source: Annals of Internal Medicine - December 5, 2017 Category: Internal Medicine Authors: Burns RB, Graham K, Sawhney MS, Reynolds EE Tags: Ann Intern Med Source Type: research

Aspirin for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: A Decision Analysis for the U.S. Preventive Services Task Force.
Conclusion: Lifetime aspirin use for primary prevention initiated at younger ages (40 to 69 years) and in persons with higher CVD risk shows the greatest potential for positive net benefit. Primary Funding Source: Agency for Healthcare Research and Quality. PMID: 27064573 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - April 11, 2016 Category: Internal Medicine Authors: Dehmer SP, Maciosek MV, Flottemesch TJ, LaFrance AB, Whitlock EP Tags: Ann Intern Med Source Type: research