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Source: Cancer Research
Cancer: Colorectal Cancer

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Total 94 results found since Jan 2013.

Abstract 5358: IL-4/IL-13 induce Duox2/DuoxA2 expression and reactive oxygen production in human pancreatic and colon cancer cells
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) contribute significantly to inflammation-associated carcinogenesis. Expression of dual oxidase 2 (Duox2), one of seven members of the NOX gene family, is up-regulated in inflammatory bowel disease, chronic pancreatitis, and in many human malignancies including carcinomas of the prostate, lung, and breast. Previously, we demonstrated that Stat1 and/or NF-κB play a critical role in modulating the enhanced expression of Duox2, and its cognate maturation factor DuoxA2, by IFN-γ and lipopolysaccharide in human pancreatic cancer cells. This cytokine-mediated increase in...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wu, Y., Doroshow, J. H. Tags: Carcinogenesis Source Type: research

Abstract 5150: JMJD3 suppresses progression of colorectal carcinoma by regulating cell cycle and anti-apoptosis
Conclusion: We showed the expression of JMJD3 in carcinoma tissue was lower than in normal tissue and demonstrated that the down-regulation of JMJD3 resulted in the increase of cell proliferation, acceleration of cell cycle and anti-apoptosis in vitro analysis. These results suggest that JMJD3 is a tumor suppressor gene for colorectal carcinoma. Note: This abstract was not presented at the meeting. Citation Format: Ryuma Tokunaga, Shigeki Nakagawa, Yasuo Sakamoto, Ryuichi Karashima, Satoshi Ida, Yu Imamura, Takatsugu Ishimoto, Shiro Iwagami, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Hideo Baba. JMJD3 suppresses progres...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Tokunaga, R., Nakagawa, S., Sakamoto, Y., Karashima, R., Ida, S., Imamura, Y., Ishimoto, T., Iwagami, S., Baba, Y., Miyamoto, Y., Yoshida, N., Baba, H. Tags: Molecular and Cellular Biology Source Type: research

Abstract 5362: Deficiencies in mismatch repair proteins induce elevated levels of acrolein-derived 1,N2-propanodeoxyguanosine and apoptosis in human colon cancer cells treated with acrolein
This study shows that MMR proteins, MLH1 and MSH2, are involved in the repair of Acr-dG. The results also suggest that Acr-dG may cause double-strand breaks which lead to apoptosis. Whether MMR acts as an independent repair pathway for Acr-dG or MMR proteins cross-talk and interact with other DNA repair pathways, such as NER, is under investigation. (Supported by NCI grant CA43159) Citation Format: Jishen Pan, Zhuoli Xuan, Marcin Dyba, Yongwei Zhang, Ying Fu, Rabindra Roy, Louis M. Weiner, Fung-Lung Chung. Deficiencies in mismatch repair proteins induce elevated levels of acrolein-derived 1,N2-propanodeoxyguanosine and apo...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Pan, J., Xuan, Z., Dyba, M., Zhang, Y., Fu, Y., Roy, R., Weiner, L. M., Chung, F.-L. Tags: Carcinogenesis Source Type: research

Abstract 5382: A breakthrough in application of a drug delivery nanoparticle system for therapy and diagnosis of solid tumor
Conclusion: Our data suggest that sCA itself, while designed as an in vivo delivery device, can facilitate entrance of low molecular chemicals into tumor cells in vitro and in vivo. Citation Format: Xin Wu, Hirofumi Yamamoto, Mamoru Uemura, Taishi Hata, Junichi Nishimura, Ichiro Takemasa, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori. A breakthrough in application of a drug delivery nanoparticle system for therapy and diagnosis of solid tumor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wu, X., Yamamoto, H., Uemura, M., Hata, T., Nishimura, J., Takemasa, I., Mizushima, T., Doki, Y., Mori, M. Tags: Cancer Chemistry Source Type: research

Abstract 3903: A sub-set of DCLK1+ve colon cancer stem cells (CSCs) survive curcumin induced autophagy, while co-treatment with curcumin +DCLK1-siRNA eliminates CSCs: Role of long and short isofoms of DCLK1
Conclusion. Our studies strongly suggest that, 1) DCLK1 represents a functional protein for colon cancers, 2) combination of curcumin+DCLK1-siRNA may target and eradicate colon cancer stem cells., and 3) identifying small molecules that inhibit expression of S-isoform may allow to specifically target cancer stem cells, while sparing normal stem cells for cancer treatment purposes. This work was supported by NIH Granst to PS (R01CA09795909 and RO1CA0975909-S1). Citation Format: Shubhashish Sarkar, Malaney O'Connell, Carla, Kantara, Pomila Singh. A sub-set of DCLK1+ve colon cancer stem cells (CSCs) survive curcumin induced a...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Sarkar, S., O'Connell, M., Kantara, C., Singh, P. Tags: Tumor Biology Source Type: research

Abstract SY43-03: Screening for triple negative breast cancer vulnerabilities
There is no targeted therapy for triple negative breast cancers (TNBC), which have the worst prognosis of human breast cancers. TNBCs are prone to relapse and metastasize after cytotoxic drug treatment. This group of cancers, defined by low or absent expression of estrogen, progesterone and Her2 receptors, are heterogeneous in genetic, epigenetic and phenotypic features, making it difficult to identify specific drug targets suitable for this group of cancers as a whole. About half or more of TNBCs have an epithelial phenotype (classified based on gene expression profiling as basal-like or basal-A) and a large minority of t...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Petrocca, F., Altschuler, G., Tan, S. M., Mendillo, M. L., Yan, H., Jerry, D. J., Kung, A. L., Hide, W., Ince, T. A., Lieberman, J. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 5112: Histone deacetylase and proteasome inhibitors synergistically induce apoptosis in colon cancer, multiple myeloma and CTCL cells through induction of the immediate early genes ATF3 and JUN
Conclusions: This study provides insight into the mechanistic basis by which combination treatment with HDAC and proteasome inhibitors synergistically induces apoptosis in tumour cells. Citation Format: Janson WT Tse, Anderly C. Chueh, Ian Y. Luk, Fiona Chionh, Yvonne Yeung, Georgia A. Corner, Dominic CH Ng, Hoanh Tran, Amardeep S. Dhillon, John M. Mariadason. Histone deacetylase and proteasome inhibitors synergistically induce apoptosis in colon cancer, multiple myeloma and CTCL cells through induction of the immediate early genes ATF3 and JUN. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Associ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Tse, J. W., Chueh, A. C., Luk, I. Y., Chionh, F., Yeung, Y., Corner, G. A., Ng, D. C., Tran, H., Dhillon, A. S., Mariadason, J. M. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3485: Efficient transfection of cancer cell lines using the 4D-NucleofectorTM System
In this study we used the 4D-Nucleofector™ System in combination with the 96-well Shuttle™ Add-on for optimizing transfection conditions for multiple cancer cell lines. An exemplary optimization process is depicted for the human prostate carcinoma cell line DU 145 and for the human colorectal adenocarcinoma cell line COLO 205. Optimization steps included the selection of the appropriate Nucleofector™ Solution, Nucleofector™ Program and plasmid DNA concentration. Transfection parameters were thereby optimized for a variety of adherent and non-adherent human cancer cell lines resulting in transfection efficiencies of...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Schroeder, J., Altrogge, L., Lorbach, E., Kokatam, S., Schaepermeier, S., Weigel, M., Andretta-Beu, G., Buesch, S., Grabeck, T., Krumnow, A., Spicker, S., Kallol, S., Kapoor, P., Toell, A. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3526: The mTORC2 component RICTOR plays a key role in lung cancer cell growth
RICTOR (Rapamycin-insensitive companion of mTOR protein) is a key component of mTORC2 (the mammalian target of rapamycin complex 2). One of the most-recognized targets for RICTOR-mTORC2 is AKT (Ser473). RICTOR also carries functions independent of mTORC2. RICTOR signaling has been suggested to play key roles in regulating cancer cell migration, invasion and metastasis in breast, ovarian, colorectal cancers and gliomas. The potential roles of RICTOR in lung cancer remain to be elucidated. We first examined the expression profile of RICTOR in primary lung tumor specimens and in lung cancer cell lines by immunohistochemistry....
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Cheng, H., Zou, Y., Borczuk, A., Qiu, W., Piperdi, B., Kim, M., Halmos, B., Perez–Soler , R. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3537: Suppression of miR-145 by long noncoding RNA RoR in colon cancer
Conclusion: Taken together, these results suggest that lncRNA-RoR plays an oncogene role in colon cancer in part through suppression of the tumor suppressor miR-145. Thus, a better understanding of the p53-RoR-miR-145 regulatory system will provide new insight of colon cancer therapy. Citation Format: Jianguo Huang, Yin-Yuan Mo. Suppression of miR-145 by long noncoding RNA RoR in colon cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3537. doi:10.1158/1538-7445.AM2014-3537
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Huang, J., Mo, Y.-Y. Tags: Molecular and Cellular Biology Source Type: research

Abstract 4897: Genetic variants and expression of AEG-1 in relation to clinical outcome and radiotherapy response in colorectal cancer patients and cell lines
Background: Colorectal cancer (CRC) is the third most common cancer in men and the second in woman worldwide. The therapy of CRC has been critically improved during the past two decades, but the treatment response varies significantly between different treatments and patients. Therefore it is of need to search for biomarkers for more suitable prognosis and treatment. The aim of this study was to investigate genetic variants of the astrocyte elevated gene-1 (AEG-1), its expression in CRC patient samples and colon cancer cell lines and the potential correlation to clinicopathological variables and treatment response. Materia...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gnosa, S., Brodin, V. P., Ticha, I., Adell, G., Arbman, G., Zhang, H., Sun, X.-F. Tags: Tumor Biology Source Type: research

Abstract 5267: Pro-inflammatory CXCL8 signaling potentiates survival of K-Ras mutant colorectal cancer cells
Conclusions: CXCL8 signaling is elevated in K-Ras and PI3KCA mutant cancers. The up-regulation of autocrine CXCL8 signaling is linked to the promotion of cell survival, principally mediated through the inhibition of apoptosis and promotion of RTK signaling. The clinical relevance of CXCL8 signaling in modulating outcome of K-Ras mutant CRC to current treatments remains to be determined. However, CXCL8-directed therapies may be relevant as chemo-sensitizing agents in K-Ras and/or PIK3CA mutant tumors. Citation Format: Laura M. Campbell, Olabode Oladipo, Pamela J. Maxwell, Daniel Longley, Richard H. Wilson, David JJ Waugh. P...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Campbell, L. M., Oladipo, O., Maxwell, P. J., Longley, D., Wilson, R. H., Waugh, D. J. Tags: Molecular and Cellular Biology Source Type: research

Abstract 4992: Zkscan3 facilitates invasion of colorectal cancer associated with ceacam5
Conclusion: ZKSCAN3 is related with colorectal tumor progression and invasion. ZKSCAN3 overexpression tumor may facilitate metastasis of colorectal cancer associated with CEACAM5. Citation Format: Seon Ae Roh, Chan Wook Kim, Ka Hee Tak, Jin Cheon Kim. Zkscan3 facilitates invasion of colorectal cancer associated with ceacam5. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4992. doi:10.1158/1538-7445.AM2014-4992
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Roh, S. A., Kim, C. W., Tak, K. H., Kim, J. C. Tags: Tumor Biology Source Type: research

Abstract 5204: MicroRNA-6734 induces p21 gene expression by targeting a complementary p21 promoter sequence and inhibits colon cancer cells
MicroRNAs (miRNAs) regulate gene expression by binding to the cellular transcript leading to translational repression or degradation of the target mRNA. However, miRNA have also been shown to induce gene expression by targeting promoter in a phenomenon referred to as RNA activation (RNAa). Recently, p21 promoter targeted small activating RNA, dsP21-322, has been shown to inhibit the growth of various cancer cells. The purpose of this study was to investigate the effects of miR-6734, which has a sequence homology with dsP21-322, on p21 gene activation and cell growth inhibition in HCT116 human colon cancer cells. miR-6734 i...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Kang, M. R., Yun, J., Oh, S. J., Lee, C. W., Park, K. H., Kang, J. S. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3355: Inhibiting glyoxylase 1 as a strategy to target highly glycolytic cancer cells
Cancer cells typically display altered glucose metabolism characterized by a preference of aerobic glycolysis (Warburg effect) resulting in higher levels of glycolytic waste including methylglyoxal (MG). GLO1 (Glyoxalase 1) functions in the detoxification of MG: MG reacts with glutathione to form hemithioacetal, which is converted into S-D-Lactoylglutathione by GLO1 and further metabolised into D-lactate by GLO2. When not detoxified, MG acts as a cytotoxic reagent by forming DNA- and protein-adducts (advanced glycation end products = AGEs) that subsequently lead to cell death. Therefore, GLO1 has been discussed as a potent...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gruenewald, S., Steckel, M., Timmermann, A., Rehwinkel, H., Steigemann, P., Zacharias, S., Walter, A., Bauser, M., Haegebarth, A. Tags: Molecular and Cellular Biology Source Type: research