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Research Articles Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models
Platelets are crucial for normal hemostasis; however, their hyperactivation also contributes to many potentially lethal pathologies including myocardial infarction, stroke, and cancer. We hypothesized that modified platelets lacking their aggregation and activation capacity could act as reversible inhibitors of platelet activation cascades. Here, we describe the development of detergent-extracted human modified platelets (platelet decoys) that retained platelet binding functions but were incapable of functional activation and aggregation. Platelet decoys inhibited aggregation and adhesion of platelets on thrombogenic surfa...
Source: Science Translational Medicine - February 13, 2019 Category: Biomedical Science Authors: Papa, A.-L., Jiang, A., Korin, N., Chen, M. B., Langan, E. T., Waterhouse, A., Nash, E., Caroff, J., Graveline, A., Vernet, A., Mammoto, A., Mammoto, T., Jain, A., Kamm, R. D., Gounis, M. J., Ingber, D. E. Tags: Research Articles Source Type: research

The Association between Exposure to Second-Hand Smoke and Disease in the Chinese Population: A Systematic Review and Meta-Analysis
CONCLUSION: The effect of SHS exposure in China was similar to that in Western countries, but its definition and characterization require further clarification. Studies on the association between SHS exposure and certain diseases with high incidence rates are insufficient.PMID:36650679 | DOI:10.3967/bes2023.003
Source: Biomedical and Environmental Sciences : BES - January 18, 2023 Category: Biomedical Science Authors: Yu Tong Wang Kui Ru Hu Jian Zhao Fei Ling Ai Yu Lin Shi Xue Wei Wang Wen Yi Yang Jing Xin Wang Li Mei Ai Xia Wan Source Type: research

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