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Inhibition Of Fatty Acid Amide Hydrolase Activates Nrf2 Signaling And Induces Heme Oxygenase 1 Transcription In Breast Cancer Cells
Conclusions and ImplicationsThese data uncovered a novel mechanism by which inhibition of FAAH or exposure to AEA induced HO‐1 transcripts and implicating AEA and FAAH as direct modifiers in signaling mediated activation of Nrf2‐HO‐1 pathway, independent of cannabinoid receptors.
Source: British Journal of Pharmacology - January 24, 2013 Category: Drugs & Pharmacology Authors: H Li, JT Wood, KM Whitten, SK Vadival, S Seng, A Makriyannis, S Avraham, HK Avraham Tags: Research Paper Source Type: research

Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.
Abstract All-trans retinoic acid (atRA) is the active form of vitamin A, known to activate retinoid receptors, especially the heterodimer retinoid X receptor (RXR):retinoic acid receptor (RAR) that otherwise may play a role in regulation of some drug transporters. The present study was designed to characterize the nature of human hepatic transporters that may be targeted by atRA and the heterodimer RXR:RAR. Exposure of human hepatoma HepaRG cells and primary human hepatocytes to 5 μM atRA down-regulated mRNA levels of various sinusoidal solute carrier (SLC) influx transporters, including organic anion transportin...
Source: European Journal of Pharmaceutical Sciences - January 22, 2013 Category: Drugs & Pharmacology Authors: Le Vee M, Jouan E, Stieger B, Fardel O Tags: Eur J Pharm Sci Source Type: research

Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress.
In conclusion, SD inhibits breast cancer cell growth and induces interplay between apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress. It will provide molecular bases for developing SD into a drug candidate for the treatment of breast cancer. PMID: 23348250 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - January 21, 2013 Category: Drugs & Pharmacology Authors: Shi JM, Bai LL, Zhang DM, Yiu A, Yin ZQ, Han WL, Liu JS, Li Y, Fu DY, Ye WC Tags: Biochem Pharmacol Source Type: research

Targeted Delivery of siRNA into Breast Cancer Cells via Phage Fusion Proteins
Molecular PharmaceuticsDOI: 10.1021/mp3006006
Source: Molecular Pharmaceutics - January 8, 2013 Category: Drugs & Pharmacology Authors: Deepa Bedi, James W. Gillespie, Vasily A. Petrenko, Andreas Ebner, Michael Leitner, Peter Hinterdorfer and Valery A. Petrenko Source Type: research

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