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Management: Mergers and Aquisitions
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The EMT Phenotype Confers Resistance to CTLs
In this study, we investigated the functional consequences of this mode of epithelial cell plasticity on targeted cell lysis by cytotoxic T lymphocytes (CTL). Acquisition of the EMT phenotype in various derivatives of MCF-7 human breast cancer cells was associated with dramatic morphologic changes and actin cytoskeleton remodeling, with CD24−/CD44+/ALDH+ stem cell populations present exhibiting a higher degree of EMT relative to parental cells. Strikingly, acquisition of this phenotype also associated with an inhibition of CTL-mediated tumor cell lysis. Resistant cells exhibited attenuation in the formation of an immunol...
Source: Cancer Research - April 15, 2013 Category: Cancer & Oncology Authors: Akalay, I., Jan&jnodot;i, B., Hasmim, M., Noman, M. Z., Andre, F., De Cremoux, P., Bertheau, P., Badoual, C., Vielh, P., Larsen, A. K., Sabbah, M., Tan, T. Z., Keira, J. H., Ying Hung, N. T., Thiery, J. P., Mami–Chouaib, F., Chouaib, S. Tags: Priority Reports Source Type: research
