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AMPK in TRAIL Combination-induced Apoptosis Signal Transduction
Prostate cancer (PCa) is one of the most frequently diagnosed cancers in men with limited treatment options for the hormone-resistant forms. Development of novel therapeutic options is critically needed to target advanced forms. Here we demonstrate that combinatorial treatment with the thiazolidinedione troglitazone (TZD) and TNF-related apoptosis-inducing ligand (TRAIL) can induce significant apoptosis in various PCa cells independent of androgen receptor status. Because TZD is known to activate AMP-activated protein kinase (AMPK), we determined whether AMPK is a molecular target mediating this apoptotic cascade by utiliz...
Source: Journal of Biological Chemistry - September 4, 2015 Category: Chemistry Authors: Santha, S., Viswakarma, N., Das, S., Rana, A., Rana, B. Tags: Cell Biology Source Type: research