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The role of RhoC in epithelial-to-mesenchymal transition of ovarian carcinoma cells
Conclusion: RhoC expression might be involved in EMT of ovarian epithelial carcinoma cells, stimulated by TGF-beta1 and VEGF.
Source: BioMed Central - July 1, 2014 Category: Journals (General) Authors: Wen-feng GouYang ZhaoHang LuXue-feng YangYin-ling XiuShuang ZhaoJian-min LiuZhi-tu ZhuHong-zhi SunYun-peng LiuFeng XuYasuo TakanoHua-chuan Zheng Source Type: research

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma
Conclusions: Acquisitions of p53 mutations contributed to the resistance of HCC to arsenic trioxide. Nutlin-3 could overcome arsenic trioxide resistance and inhibit tumor metastasis through p73 activation and promoting mutant p53 degradation mediated by arsenic trioxide.
Source: BioMed Central - May 31, 2014 Category: Journals (General) Authors: Tongsen ZhengDalong YinZhaoyang LuJiabei WangYuejin LiXi ChenYingjian LiangXuan SongShuyi QiBoshi SunChangming XieXianzhi MengShangha PanJiaren LiuHongchi JiangLianxin Liu Source Type: research

Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
Conclusions: Given DCLK1's tumor stem cell marker status, a strong understanding of its biological role and interactions in gastrointestinal tumors may lead to discoveries that improve patient outcomes. The results of this study suggest that small molecule inhibitors of DCLK1 kinase should be further investigated as they may hold promise as anti-tumor stem cell drugs.
Source: BioMed Central - May 6, 2014 Category: Journals (General) Authors: Nathaniel WeygantDongfeng QuWilliam L BerryRandal MayParthasarathy ChandrakesanDaniel B OwenSripathi M SurebanNaushad AliRalf JanknechtCourtney W Houchen Source Type: research

SLUG is activated by nuclear factor kappa B and confers human alveolar epithelial A549 cells resistance to tumor necrosis factor-alpha-induced apoptosis
Conclusions: The findings suggested that TNF-alpha treatment promoted apoptosis via the NF-kappaB-dependent PUMA pathway. The anti-apoptotic role of TNF-alpha was via NF-kappaB-dependent SLUG and Bcl-2 pathway at a later time.
Source: BioMed Central - January 22, 2013 Category: Journals (General) Authors: Yaopeng WangBin YueXuyi YuZhan WangMingzhao Wang Source Type: research

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