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Targeting Hexokinase II to mitochondria to modulate energy metabolism and reduce ischemia‐reperfusion injury in heart
Summary Mitochondrially‐bound hexokinase II (mtHKII) has long been known to confer cancer cells with their resilience against cell death. More recently, mtHKII has emerged as a powerful protector against cardiac cell death. mtHKII protects against IR injury in skeletal muscle and heart, attenuates cardiac hypertrophy and remodelling, and is one of the major end‐effectors through which ischemic preconditioning protects against myocardial ischemia‐reperfusion injury. Mechanisms of mtHKII cardioprotection against reperfusion injury entail the maintenance of regulated OMM permeability during ischemia and reperfusion resu...
Source: British Journal of Pharmacology - August 30, 2013 Category: Drugs & Pharmacology Authors: Rianne Nederlof, Otto Eerbeek, Markus W Hollmann, Richard Southworth, Coert J Zuurbier Tags: Review Article Source Type: research

Therapeutic Potential of Midkine in Cardiovascular Diseases
Abstract Ischemic heart disease, stroke and their pathological consequences are life‐threatening diseases that account for about half of deaths in developed countries. Pathology of these diseases includes cell death due to ischemia/reperfusion injury, vascular stenosis, and cardiac remodeling. The growth factor midkine plays a pivotal role in these events. Midkine shows an acute cytoprotective effect in ischemia/reperfusion injury at least in part via its anti‐apoptotic effect. Moreover, while midkine promotes endothelial cell proliferation, it also recruits inflammatory cells to lesions. These activities eventually en...
Source: British Journal of Pharmacology - November 28, 2013 Category: Drugs & Pharmacology Authors: Kenji Kadomatsu, Péter Bencsik, Anikó Görbe, Csaba Csonka, Kazuma Sakamoto, Satoshi Kishida, Péter Ferdinandy Tags: Review Article – Midkine Themed Issue Source Type: research

Therapeutic potential of midkine in cardiovascular disease
This article is part of a themed section on Midkine. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐4
Source: British Journal of Pharmacology - January 24, 2014 Category: Drugs & Pharmacology Authors: Kenji Kadomatsu, Péter Bencsik, Anikó Görbe, Csaba Csonka, Kazuma Sakamoto, Satoshi Kishida, Péter Ferdinandy Tags: REVIEW Source Type: research

Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia‐reperfusion injury in heart
This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue‐8
Source: British Journal of Pharmacology - March 28, 2014 Category: Drugs & Pharmacology Authors: Rianne Nederlof, Otto Eerbeek, Markus W Hollmann, Richard Southworth, Coert J Zuurbier Tags: Review Source Type: research