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Source: Cell Reports
Cancer: Cancer
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Total 11 results found since Jan 2013.
Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
Publication date: Available online 3 March 2016 Source:Cell Reports Author(s): James Campbell, Colm J. Ryan, Rachel Brough, Ilirjana Bajrami, Helen N. Pemberton, Irene Y. Chong, Sara Costa-Cabral, Jessica Frankum, Aditi Gulati, Harriet Holme, Rowan Miller, Sophie Postel-Vinay, Rumana Rafiq, Wenbin Wei, Chris T. Williamson, David A. Quigley, Joe Tym, Bissan Al-Lazikani, Timothy Fenton, Rachael Natrajan, Sandra J. Strauss, Alan Ashworth, Christopher J. Lord One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell line...
Source: Cell Reports - March 4, 2016 Category: Cytology Source Type: research
YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression
Publication date: Available online 12 March 2015 Source:Cell Reports Author(s): Julien Fitamant , Filippos Kottakis , Samira Benhamouche , Helen S. Tian , Nicolas Chuvin , Christine A. Parachoniak , Julia M. Nagle , Rushika M. Perera , Marjorie Lapouge , Vikram Deshpande , Andrew X. Zhu , Albert Lai , Bosun Min , Yujin Hoshida , Joseph Avruch , Daniela Sia , Genís Campreciós , Andrea I. McClatchey , Josep M. Llovet , David Morrissey , Lakshmi Raj , Nabeel Bardeesy Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms...
Source: Cell Reports - March 13, 2015 Category: Cytology Source Type: research
Differential Effector Engagement by Oncogenic KRAS
Publication date: 13 February 2018 Source:Cell Reports, Volume 22, Issue 7 Author(s): Tina L. Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A. Strathern, Katie Powell, Brian Smith, Andrew M. Waters, David Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T. Stein, Ellen Murchie, Eliane Cortez, Regina K. Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott W. Lowe, Cyril H. Benes, Frank McCormick KRAS can bind numerous effector proteins, which activate different downstream signal...
Source: Cell Reports - February 24, 2018 Category: Cytology Source Type: research
Specific Myosins Control Actin Organization, Cell Morphology, and Migration in Prostate Cancer Cells
Publication date: Available online 6 December 2015 Source:Cell Reports Author(s): Katarzyna A. Makowska, Ruth E. Hughes, Kathryn J. White, Claire M. Wells, Michelle Peckham We investigated the myosin expression profile in prostate cancer cell lines and found that Myo1b, Myo9b, Myo10, and Myo18a were expressed at higher levels in cells with high metastatic potential. Moreover, Myo1b and Myo10 were expressed at higher levels in metastatic tumors. Using an siRNA-based approach, we found that knockdown of each myosin resulted in distinct phenotypes. Myo10 knockdown ablated filopodia and decreased 2D migration speed....
Source: Cell Reports - December 7, 2015 Category: Cytology Source Type: research
Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis
Publication date: Available online 10 December 2015 Source:Cell Reports Author(s): Rajesha Rupaimoole, Jaehyuk Lee, Monika Haemmerle, Hui Ling, Rebecca A. Previs, Sunila Pradeep, Sherry Y. Wu, Cristina Ivan, Manuela Ferracin, Jennifer B. Dennison, Niki M. Zacharias Millward, Archana S. Nagaraja, Kshipra M. Gharpure, Michael McGuire, Nidhin Sam, Guillermo N. Armaiz-Pena, Nouara C. Sadaoui, Cristian Rodriguez-Aguayo, George A. Calin, Ronny I. Drapkin, Jeffery Kovacs, Gordon B. Mills, Wei Zhang, Gabriel Lopez-Berestein, Pratip K. Bhattacharya, Anil K. Sood Long noncoding RNAs (lncRNAs...
Source: Cell Reports - December 12, 2015 Category: Cytology Source Type: research
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers
Publication date: 1 November 2016 Source:Cell Reports, Volume 17, Issue 6 Author(s): Hiroto Hatakeyama, Sherry Y. Wu, Yasmin A. Lyons, Sunila Pradeep, Wanqin Wang, Qian Huang, Karem A. Court, Tao Liu, Song Nie, Cristian Rodriguez-Aguayo, Fangrong Shen, Yan Huang, Takeshi Hisamatsu, Takashi Mitamura, Nicholas Jennings, Jeajun Shim, Piotr L. Dorniak, Lingegowda S. Mangala, Marco Petrillo, Vladislav A. Petyuk, Athena A. Schepmoes, Anil K. Shukla, Madeline Torres-Lugo, Ju-Seog Lee, Karin D. Rodland, Anna Fagotti, Gabriel Lopez-Berestein, Chun Li, Anil K. Sood Even though hyperthermia is a promising treatment for can...
Source: Cell Reports - October 31, 2016 Category: Cytology Source Type: research
HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients
Publication date: 20 June 2017 Source:Cell Reports, Volume 19, Issue 12 Author(s): Zhaobo Li, Lihong Zhou, Chrisostomos Prodromou, Velibor Savic, Laurence H. Pearl Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases. This provides the rationale for HSP90 inhibitors as cancer therapeutics. However, the mechanism by which HSP90 ATPase inhibition triggers ubiquitylation is not understood, and the E3 ubiquitin ligases involved are largely unknown. Using a siRNA screen, we have identified components of two...
Source: Cell Reports - June 21, 2017 Category: Cytology Source Type: research
ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): James Monypenny, Hanna Milewicz, Fabian Flores-Borja, Gregory Weitsman, Anthony Cheung, Ruhe Chowdhury, Thomas Burgoyne, Appitha Arulappu, Katherine Lawler, Paul R. Barber, Jose M. Vicencio, Melanie Keppler, Wahyu Wulaningsih, Sean M. Davidson, Franca Fraternali, Natalie Woodman, Mark Turmaine, Cheryl Gillett, Dafne Franz, Sergio A. QuezadaSummaryThe immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA screen identified the endosomal sorting co...
Source: Cell Reports - July 18, 2018 Category: Cytology Source Type: research
The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery
Publication date: 13 November 2018Source: Cell Reports, Volume 25, Issue 7Author(s): Daniel S.J. Miller, Robert D. Bloxham, Ming Jiang, Ilaria Gori, Rebecca E. Saunders, Debipriya Das, Probir Chakravarty, Michael Howell, Caroline S. HillSummarySignal transduction pathways stimulated by secreted growth factors are tightly regulated at multiple levels between the cell surface and the nucleus. The trafficking of cell surface receptors is emerging as a key step for regulating appropriate cellular responses, with perturbations in this process contributing to human diseases, including cancer. For receptors recognizing ligands of...
Source: Cell Reports - November 14, 2018 Category: Cytology Source Type: research
Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis
Publication date: 13 August 2019Source: Cell Reports, Volume 28, Issue 7Author(s): Hila Doron, Malak Amer, Nour Ershaid, Raquel Blazquez, Ophir Shani, Tzlil Gener Lahav, Noam Cohen, Omer Adler, Zahi Hakim, Sabina Pozzi, Anna Scomparin, Jonathan Cohen, Muhammad Yassin, Lea Monteran, Rachel Grossman, Galia Tsarfaty, Chen Luxenburg, Ronit Satchi-Fainaro, Tobias Pukrop, Neta ErezSummaryMelanoma is the deadliest skin cancer due to its high rate of metastasis, frequently to the brain. Brain metastases are incurable; therefore, understanding melanoma brain metastasis is of great clinical importance. We used a mouse model of spont...
Source: Cell Reports - August 14, 2019 Category: Cytology Source Type: research
Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1
Publication date: 10 December 2019Source: Cell Reports, Volume 29, Issue 11Author(s): Jiagui Song, Tianzhuo Wang, Xiaochun Chi, Xiaofan Wei, Sidi Xu, Miao Yu, Huiying He, Ji Ma, Xueying Li, Juan Du, Xiaoran Sun, Yunling Wang, Jun Zhan, Hongquan ZhangSummaryThe Hippo signaling pathway plays a key role in development and cancer progression. However, molecules that intrinsically inhibit this pathway are less well known. Here, we report that the focal adhesion molecule Kindlin-2 inhibits Hippo signaling by interacting with and degrading MOB1 and promoting the interaction between MOB1 and the E3 ligase praja2. Kindlin-2 thus in...
Source: Cell Reports - December 11, 2019 Category: Cytology Source Type: research
