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Molecular links between allergy and cancer
Trends Mol Med. 2022 Jul 4:S1471-4914(22)00158-7. doi: 10.1016/j.molmed.2022.06.003. Online ahead of print.ABSTRACTEpidemiologic studies show both positive and negative associations between allergies and cancer. Allergic diseases may protect against tumorigenesis by promoting the immune surveillance, while carcinogenesis may be promoted through inflammatory responses from allergies. Histamine receptor antagonists are the focus of recent cancer studies because of their promising beneficial effect on tumor development. Also, cytokines, particularly IL-4 or IL-33, IgE as well as allergy-related immune cells such as eosinophil...
Source: Trends in Molecular Medicine - July 6, 2022 Category: Molecular Biology Authors: Axel Lorentz Sabrina Bilotta Mehtap Civelek Source Type: research

Unleashing cell-penetrating peptide applications for immunotherapy
Trends Mol Med. 2022 Apr 21:S1471-4914(22)00078-8. doi: 10.1016/j.molmed.2022.03.010. Online ahead of print.ABSTRACTWith the advent of cancer immunotherapy, immunomodulation has emerged as an important strategy for the treatment of various diseases. We review recent advances in clinical trials of cell-penetrating peptide (CPP) applications for immunotherapy and also discuss their challenges and opportunities for preclinical studies in various immune diseases. CPP conjugation to antigenic peptides or proteins can enable efficient antigen uptake and cross-presentation by antigen-presenting cells (APCs), which induce both hum...
Source: Trends in Molecular Medicine - April 25, 2022 Category: Molecular Biology Authors: Ja-Hyun Koo Gil-Ran Kim Kyung-Ho Nam Je-Min Choi Source Type: research