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Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12
Sci Signal. 2023 Aug 22;16(799):eadg0485. doi: 10.1126/scisignal.adg0485. Epub 2023 Aug 22.ABSTRACTThe second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) evokes calcium ion (Ca2+) release from endosomes and lysosomes by activating two-pore channels (TPCs) on these organelles. Rather than directly binding to TPCs, NAADP associates with proteins that indirectly confer NAADP sensitivity to the TPC complex. We investigated whether and how the NAADP-binding proteins Jupiter microtubule-associated homolog 2 (JPT2) and like-Sm protein 12 (LSM12) contributed to NAADP-TPC-Ca2+ signaling in human cells. Biochemic...
Source: Science Signaling - August 22, 2023 Category: Biomedical Science Authors: Gihan S Gunaratne Eugen Brailoiu Sushil Kumar Yu Yuan James T Slama Timothy F Walseth Sandip Patel Jonathan S Marchant Source Type: research

COVID-19: A Review on the Role of Trace Elements Present in Saudi Arabian Traditional Dietary Supplements
Pak J Biol Sci. 2022 Jan;25(1):1-8. doi: 10.3923/pjbs.2022.1.8.ABSTRACTThe novel coronavirus infection is also called COVID-19 (coronavirus disease 2019). The infection has affected millions of people worldwide and caused morbidity as well mortality in patients with pre-existing chronic conditions such as metabolic, respiratory and cardiovascular disorders. The severity of the disease is mostly seen in people with low immunity and chronic sufferers of respiratory, cardiovascular and metabolic disorders. To date, there is no specific treatment available for COVID-19. Precaution and prevention are the most recommended option...
Source: Pakistan Journal of Biological Sciences: PJBS - January 10, 2022 Category: Biomedical Science Authors: Hani A Alfheeaid Syed Imam Rabbani Source Type: research

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