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Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2
Antimicrob Agents Chemother. 2021 Mar 1:AAC.02428-20. doi: 10.1128/AAC.02428-20. Online ahead of print.ABSTRACTMolnupiravir, EIDD-2801/MK-4482, the prodrug of the active antiviral ribonucleoside analog ß-d-N4-hydroxycytidine (NHC; EIDD-1931), has activity against a number of RNA viruses including severe acute respiratory syndrome coronavirus 2, severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus, and seasonal and pandemic influenza viruses.Single and multiple doses of molnupiravir were evaluated in this first-in-human, phase 1, randomized, double-blind, placebo-controlled study in h...
Source: Antimicrobial Agents and Chemotherapy - March 2, 2021 Category: Microbiology Authors: Wendy P Painter Wayne Holman Jim A Bush Firas Almazedi Hamzah Malik Nicola C J E Eraut Merribeth J Morin Laura J Szewczyk George R Painter Source Type: research