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Authors ’ response to Dai et al re: “Chronic constipation as a risk factor for colorectal cancer: results from a nationwide, case-control study”
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 8, 2021 Category: Gastroenterology Authors: Kyle Staller, Jonas F. Ludvigsson Source Type: research

High but Inequitable COVID-19 Vaccine Uptake Among Patients with Inflammatory Bowel Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 8, 2021 Category: Gastroenterology Authors: Trevor L. Schell, Luke J. Richard, Katharine Tippins, Rachel K. Russ, Mary S. Hayney, Freddy Caldera Source Type: research

Abdomino-anal Dyscoordination in Defecatory Disorders
The contribution of the abdominal muscles to normal defecation and disturbances thereof in defecatory disorders (DD) are unknown. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2021 Category: Gastroenterology Authors: Sushmitha Grama Srinivasan, Anjani Muthyala, Mayank Sharma, Kelly Feuerhak, Andrea Boon, Kent R. Bailey, Adil E. Bharucha Source Type: research

2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis
The increasing rates of obesity and type 2 diabetes mellitus may lead to increased prevalence of nonalcoholic fatty liver disease (NAFLD). We aimed to determine the current and recent trends on the global and regional prevalence of NAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 6, 2021 Category: Gastroenterology Authors: Michael H. Le, Yee Hui Yeo, Xiaohe Li, Jie Li, Biyao Zou, Yuankai Wu, Qing Ye, Daniel Q. Huang, Changqing Zhao, Jie Zhang, Chenxi Liu, Na Chang, Feng Xing, Shiping Yan, Wan Zi Hui, Natasha Tang Sook Yee, Maeda Mayumi, Xinting Liu, Chuanli Liu, Fajuan Rui, Source Type: research

Reply
We thank Drs Giri and Sundaram for their letter and interest in our study. As you know, we have had a keen interest in this potential second clinical phenotype of esophageal adenocarcinoma (EAC) and agree that this subtype may need to be analyzed differently. However, it is also important to note that epidemiologic modeling suggests that this type of EAC likely starts with intestinal metaplasia.1 Furthermore, a molecular difference in the 2 EAC phenotypes has not yet yielded different molecular routes to cancer. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 6, 2021 Category: Gastroenterology Authors: Tarek Sawas, David A. Katzka Tags: Letter to the Editor Source Type: research

Reply
We thank Dr Suprabhat Giri and coworkers for their interest in our study1 and for highlighting several important issues. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 6, 2021 Category: Gastroenterology Authors: Octavi Bassegoda, Pol Olivas, Isabel Graupera, Virginia Hern ández-Gea Tags: Letter to the Editor Source Type: research

2019 global NAFLD prevalence - A systematic review and meta-analysis
The increasing rates of obesity and type 2 diabetes mellitus may lead to increased prevalence of NAFLD. We aimed to determine the current and recent trends on the global and regional prevalence of NAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 6, 2021 Category: Gastroenterology Authors: Michael H. Le, Yee Hui Yeo, Xiaohe Li, Jie Li, Biyao Zou, Yuankai Wu, Qing Ye, Daniel Q. Huang, Changqing Zhao, Jie Zhang, Chenxi Liu, Na Chang, Feng Xing, Shiping Yan, Wan Zi Hui, Natasha Tang Sook Yee, Maeda Mayumi, Xinting Liu, Chuanli Liu, Fajuan Rui, Source Type: research

Reply to “Decompensation in patients with advanced NAFLD – more questions that need answering”
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 6, 2021 Category: Gastroenterology Authors: Octavi Bassegoda, Pol Olivas, Isabel Graupera, Virginia Hern ández-Gea Source Type: research

In response to Drs. Giri and Sundaram CGH-D-21-02677
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 6, 2021 Category: Gastroenterology Authors: Tarek Sawas, David A. Katzka Source Type: research

Intensive Lifestyle Management Improves Steatosis and Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease
Childhood obesity, with associated comorbidities such as nonalcoholic fatty liver disease (NAFLD), is an increasing global health problem. Although lifestyle management is the mainstay of treatment, its efficacy on liver fibrosis has not yet been established. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 3, 2021 Category: Gastroenterology Authors: Sander Lefere, Ellen Dupont, Ann De Guchtenaere, Stephanie Van Biervliet, Saskia Vande Velde, Xavier Verhelst, Lindsey Devisscher, Hans Van Vlierberghe, Anja Geerts, Ruth De Bruyne Source Type: research

Impact of Bile Acid Diarrhea in Patients with Diarrhea-Predominant Irritable Bowel Syndrome on Symptoms and Quality of Life
Bile acid diarrhea (BAD) affects about a quarter of patients with irritable bowel syndrome with diarrhea (IBS-D). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 3, 2021 Category: Gastroenterology Authors: Joelle BouSaba, Wassel Sannaa, Sanna McKinzie, Priya Vijayvargiya, Victor Chedid, Xiao Jing Wang, Jessica Atieh, Ting Zheng, Justin Brandler, Ann L. Taylor, Irene Busciglio, W. Scott Harmsen, Michael Camilleri Source Type: research

An Observational Data Meta-Analysis on the Differences in Prevalence and Risk Factors Between MAFLD vs NAFLD
The shift to redefine non-alcoholic fatty liver disease (NAFLD) as metabolic associated fatty liver disease (MAFLD) can profoundly affect patient care, healthcare professionals, and progress within the field. To date, there remains no consensus on the characterization of NAFLD versus MAFLD. Thus, this study sought to compare the differences between the natural history of NAFLD and MAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 3, 2021 Category: Gastroenterology Authors: Grace En Hui Lim, Ansel Tang, Cheng Han Ng, Yip Han Chin, Wen Hui Lim, Darren Jun Hao Tan, Jie Ning Yong, Jieling Xiao, Chloe Wen-Min Lee, Mark Chan, Nicholas WS. Chew, Eunice Xiang Xuan Tan, Mohammad Shadab Siddiqui, Daniel Huang, Mazen Noureddin, Arun J Source Type: research

Intensive lifestyle management improves steatosis and fibrosis in pediatric non-alcoholic fatty liver disease
Childhood obesity, with associated comorbidities such as non-alcoholic fatty liver disease (NAFLD), is a growing global health problem. Although lifestyle management is the mainstay of treatment, its efficacy on liver fibrosis has not yet been established. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 3, 2021 Category: Gastroenterology Authors: Sander Lefere, Ellen Dupont, Ann De Guchtenaere, Stephanie Van Biervliet, Saskia Vande Velde, Xavier Verhelst, Lindsey Devisscher, Hans Van Vlierberghe, Anja Geerts, Ruth De Bruyne Source Type: research

Reply
We thank Xie and Xu for their interest in our study, “Coffee Consumption is Associated with Lower Liver Stiffness: A Nationally Representative Study.”1,2 We would like to address each of their comments. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 2, 2021 Category: Gastroenterology Authors: Sebastian Niezen, Elliot B. Tapper Tags: Letter to the Editor Source Type: research

Reply. Coffee consumption and lower liver stiffness: the risk for residual confounders should be considered
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 2, 2021 Category: Gastroenterology Authors: Sebastian Niezen, Elliot B. Tapper Source Type: research