Newly discovered windows of brain plasticity may help with treatment of stress-related disorders
Even under repeated stress, the brain maintains the potential to adapt and recover. Researchers have shown how changes in gene expression cause these transitory opportunities to open up. Their results suggest well-timed treatment could change the trajectory of a brain suffering from depression or other disorder. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 22, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Bruce McEwen Bruce S. McEwen Carla Nasca epigenetics Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology mGlu2 P300 Stress Source Type: news

Study links epigenetic processes to the development of the cerebellar circuitry
Researchers have, for the first time, described the pivotal changes responsible for controlling the formation of the part of the brain that allows us to learn and execute complex movements. These changes involve modifications to chromatin, which is DNA packaged with protein. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 21, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News cerebellum chromatin epigenetics Laboratory of Developmental Neurobiology Mary E. Hatten Source Type: news

Experiments explain the events behind molecular ‘bomb’ seen in cancer cells
Sometimes, in cancer cells, a part of a chromosome looks like it has been pulverized, then put back together incorrectly, leading to multiple mutations. New research from The Rockefeller University describes the cellular events leading to this molecular explosion, which serves as a precursor to cancer. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 17, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News cancer chromatin chromothripsis Laboratory of Cell Biology and Genetics telomeres Titia de Lange Source Type: news

New research explores how the fly brain reroutes odor information to produce flexible behavior
Taking advantage of the simple architecture of the fruit fly brain, scientists examined how the molecule dopamine acts like an operator at a switchboard, changing the flow of information. Their work helps explain why the same stimulus can lead to different responses, and quite likely has parallels in the human brain. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 17, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Source Type: news

Widespread skewed expression of mRNA components correlate with fine tuning of protein production
In numerous tissues and genes, the researchers found lopsided ratios in two parts of mRNA transcripts of genes, one of which carries the code for a protein and one that doesn’t. They suspect some of these skewed ratios may help control protein production, particularly in the embryo, but also in the adult. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 16, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News 3' UTR developmental biology dopamine neurons genetics and genomics Mary Hynes mRNA sox11 Source Type: news

Luciano Marraffini receives the Hans Sigrist Prize for work on antibiotic resistance
This award, bestowed by the University of Bern, honors Marraffini for his work developing a new approach to fight antibiotic resistance. Marraffini studies CRISPR-Cas systems, which enable some bacteria to acquire immunity against viruses, and is investigating ways to use them to fight off microbial pathogens. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 15, 2015 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors antibiotic resistance CRISPR Hans Sigrist Prize Laboratory of Bacteriology Luciano Marraffini Source Type: news

Mosquitoes are tuned to seek out temperatures that match warm-blooded hosts
Researchers have described a process that allows the insects to distinguish between temperatures with high precision to find their prey. Studies like this one may help generate better repellents, traps, and other ways to control mosquitoes. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 15, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News genetic and genomics Laboratory of Neurogenetics and Behavior Leslie Vosshall mosquitos Roman Corfas Source Type: news

Groundbreaking ceremony marks start of construction on East River seawall repairs
The university has started to refurbish the damaged seawall that supports the East River Esplanade between 63rd and 68th Streets as part of the campus extension project. The esplanade will also be improved, with a new bike lane, landscaping, and a noise barrier along the FDR Drive. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 11, 2015 Category: Biomedical Science Authors: pubaff Tags: Campus News community engagement Marie-Josée and Henry R. Kravis Research Building Stavros Niarchos Foundation–David Rockefeller River Campus Source Type: news

In the News – Scientific American – Greengard turns 90
A Nobel Laureate Turning 90 Continues to Churn Out Ideas for New Drugs   “Paul Greengard has been busy. In August he co-authored a paper on molecules that appear to regulate genes that might protect against Parkinson’s. That same month … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 11, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News Laboratory of Molecular and Cellular Neuroscience Paul Greengard Source Type: news

Researchers discover new aspect of gene regulation and a possible target for cancer drugs
The expression of about three-quarters of a cell’s active genes is controlled by a process in which the DNA-transcribing enzyme hesitates before going to work. Experiments have identified the complex of proteins that helps restart this enzyme when it stalls, and so helped to explain how some promising cancer drugs work. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 10, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News gene regulation genomics and genetics Laboratory of Biochemistry and Molecular Biology Ming Yu PAF1C RNA polymerase pausing Robert G. Roeder Robert Roeder Source Type: news

Study suggests new way to help the immune system fight off sleeping sickness parasite
There are currently few treatments for the disease, and those that exist have substantial side effects. A new study reveals a method, involving epigenetic mechanisms, that causes the African sleeping sickness parasite to change into a new state, potentially making it easier for the host immune system to eliminate it. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 8, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News African sleeping sickness chromatin F. Nina Papavasiliou Günter Blobel immunology Laboratory of Lymphocyte Biology parasitic infection small-molecule inhibitors Virology and Microbiology Source Type: news

New research helps to explain how temperature shifts the circadian clock
One important aspect of the internal time-keeping system continues to perplex scientists: its complex response to temperature, which can shift the clock forward or backward, but cannot change its 24-hour period. New experiments help explain how this is possible. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 2, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Center for Studies in Physics and Biology circadian clock Eric Siggia genetics and genomics Laboratory of Genetics Michael W. Young molecular and cell biology Philip Kidd temperature compensation Source Type: news

Study reveals new mechanism in nicotine addiction
Two chemical signals, acetylcholine and glutamate, were known to act as part of the negative reward system that fuels craving, but it wasn’t clear how this happened. In new experiments, researchers have learned that one of these neurotransmitters, acetylcholine, regulates the other, glutamate, to reinforce nicotine dependence. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 1, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News addiction habenula Ines Ibanez-Tallon Laboratory of Molecular Biology molecular and cell biology Nathaniel Heintz neurosciences and behavior nicotine Source Type: news

In the News – STAT – McEwen
There’s no such thing as a male or female brain, study finds   “These results add to a complex picture that you’d never guess from media accounts and pop psych books. After decades of research, ‘we’re still debating the question … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 30, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News brain Bruce McEwen Bruce S. McEwen commentary sex differences sex hormones Source Type: news

A newly discovered signaling molecule helps neurons find their way in the developing brain
In the developing nervous system, some neurons must extend their branches to connect one half of the brain with the other. A new study sheds light on the molecular mechanisms that guide the winding paths of their axons. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 19, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Alexander Jaworski axon guidance Laboratory of Brain Development and Repair Marc Tessier-Lavigne NELL2 Netrin neurosciences and behavior Slit Source Type: news