Improvement of patient-reported outcomes in severe allergic asthma by omalizumab treatment: the real life observational PROXIMA study
ConclusionThis study demonstrated that in severe allergic asthma, omalizumab improves patient-reported outcomes such as patients ’ illness perception and QoL, while confirming improvement of asthma control and exacerbation rate reduction in Italian patients. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - November 1, 2018 Category: Allergy & Immunology Source Type: research
Potential new targets for drug development in severe asthma
AbstractIn recent years there has been increasing recognition of varying asthma phenotypes that impact treatment response. This has led to the development of biological therapies targeting specific immune cells and cytokines in the inflammatory cascade. Currently, there are two primary asthma phenotypes, Type 2 hi and Type 2 lo, which are defined by eosinophilic and neutrophilic/pauci- granulocytic pattern of inflammation respectively. Most biologics focus on Type 2 hi asthma, including all four biologics approved for treatment of uncontrolled asthma in the United States — omalizumab, mepolizumab, reslizumab, and benrali...
Source: World Allergy Organization Journal - October 25, 2018 Category: Allergy & Immunology Source Type: research
Brazilian experience with atopy patch tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis
ConclusionThe APT should be considered as an additional test when the SPT and specific serum IgE tests are negative in patients with clinical histories of allergies. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 24, 2018 Category: Allergy & Immunology Source Type: research
Brazilian experience with atopy patch tests for Dermatophagoides pteronyssinus , Dermatophagoides farinae and Blomia tropicalis
ConclusionThe APT should be considered as an additional test when the SPT and specific serum IgE tests are negative in patients with clinical histories of allergies. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 24, 2018 Category: Allergy & Immunology Source Type: research
The connection of pollen concentrations and crowd-sourced symptom data: new insights from daily and seasonal symptom load index data from 2013 to 2017 in Vienna
ConclusionMore than just the seasonal pollen index has to be considered when the SLI of a selected pollen season has to be explained. Cross-reactivity to other pollen types, allergen content and air pollution could play a considerable role. The similar behavior of the SLI in Vienna and a whole region indicate the feasibility of a possible symptom forecast in future and justifies the use of a single pollen monitoring station within a city of the size of Vienna. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 16, 2018 Category: Allergy & Immunology Source Type: research
Increasing trends of anaphylaxis-related events: an analysis of anaphylaxis using nationwide data in Taiwan, 2001 –2013
ConclusionThe incidence rate of anaphylaxis in Taiwan has increased at an average rate of 5% annually since 2001, paralleling the rising trends in several Western countries. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 10, 2018 Category: Allergy & Immunology Source Type: research
Clinical efficacy of sublingual immunotherapy is associated with restoration of steady-state serum lipocalin 2 after SLIT: a pilot study
ConclusionSerum LCN2 concentrations 9 months off-SLIT correlated with clinical reactivity in allergic patients. An increase in the LCN2 levels 9 months after HDM-SLIT was associated with a clinical benefit. Serum LCN2 may thus contribute to assess clinical reactivity in allergic patients.Trial registrationPart of the data were generated fromclinicaltrials.gov Identifier NCT01644617. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 1, 2018 Category: Allergy & Immunology Source Type: research
Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study
ConclusionsFor the diagnostic verification of clinically suspected allergy, the novel concept “from molecules to clinic” offers a reliable diagnostic workup in shorter time. Due to lower skin test numbers it is especially applicable for young children and seniors, in atopic patients, and whenever skin tests get difficult or unreliable. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - September 11, 2018 Category: Allergy & Immunology Source Type: research
Anaphylaxis triggers in a large tertiary care hospital in Qatar: a retrospective study
This study aims to examine the common triggers of anaphylaxis in Qatar.MethodsA total of 1068 electronic medical records were audited using power chart system: 446 from the medical coding system of anaphylaxis and 622 from the epinephrine auto-injectors (EAIs) dispensed during January 2012 –December 2017.ResultsOf 1068 patients, 574 (53.5%) had anaphylaxis; male to female ratio was 1.2, and 300 patients (77.9%) were less than 10 years old. The common triggers were food (n = 316, 55.0%), insect stings (n = 161, 28.0%), and drugs (n = 103, 17.9%). Common anaphylaxis food triggers were nuts (n = 173, 30.1%...
Source: World Allergy Organization Journal - September 4, 2018 Category: Allergy & Immunology Source Type: research
The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis
AbstractAllergic rhinitis (AR) is an IgE-mediated inflammatory disease of the nasal mucosa with well described local immune responses during allergen exposure. The frequent association of AR with general extra-nasal symptoms and other allergic conditions, such as conjunctivitis and asthma, however, support a more systemic disease impact. In addition to acute elevation of soluble inflammatory mediators in periphery blood, a growing number of studies have reported changes in circulating blood cells after specific nasal allergen challenge or environmental allergen exposure. These findings imply an involvement of specific bloo...
Source: World Allergy Organization Journal - August 15, 2018 Category: Allergy & Immunology Source Type: research
Appropriateness of chronic asthma management and medication adherence in patients visiting ambulatory clinic of Gondar University Hospital: a cross-sectional study
ConclusionThe findings of the study showed more than half of asthmatic patients received inappropriate treatment. Nevertheless, a larger proportion of the patients claimed to be highly adherent to their medications. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - August 10, 2018 Category: Allergy & Immunology Source Type: research
