Veterinary Immunology and Immunopathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Immune response and protection against Lawsonia intracellularis infections in pigs
Publication date: Available online 31 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Milan R. Obradovic, Heather L. WilsonAbstractLawsonia intracellularis are Gram-negative, obligate intracellular bacteria that cause proliferative enteropathy (PE), an economically important disease for the pig industry. Numerous reviews have been published on the characteristics and pathogenesis of this bacterium since its isolation and taxonomic characterization, with most reviews only partially covering how the host immune response develops during infection and the immune correlates of protection. With the develo...
Source: Veterinary Immunology and Immunopathology - November 1, 2019 Category: Veterinary Research Source Type: research

Development of antibody ELISA specific of Leptospira interrogans serovar Grippotyphosa, Canicola, and Icterohaemorrhagiae to monitor vaccine immunogenicity
Publication date: Available online 25 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Carine Cariou, Gaëtan Herbet, Prescillia Ripart, Nathalie Martin-Cagnon, Jérôme Bouvet, Michèle Schneider, Anne-Laure Guiot, Lionel CupillardAbstractThe antibody response after primary vaccination and annual revaccination with a multivalent DAPPi-L vaccine was assessed respectively in SPF dogs and in client owned dogs against the Grippotyphosa (Lg), Canicola (Lc) and Icterohaemorrhagiae (Li) Leptospira serovars. To overcome limitations of the microscopic agglutination test (MAT), we developed serovar-specific a...
Source: Veterinary Immunology and Immunopathology - October 26, 2019 Category: Veterinary Research Source Type: research

1Effects of Cyclosporine on Feline Lymphocytes Activated In Vitro
Publication date: Available online 25 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Harry Cridge, Adef Kordon, Leysa M. Pinchuk, Robert W. Wills, John M. Thomason, Andrew J. Mackin, Todd M. ArcherAbstractCyclosporine A (CsA) is a calcineurin inhibitor that is known to decrease lymphocyte expression of NFAT-regulated cytokines in humans, dogs and cats, and thereby depress lymphocyte function. Less is known about the effects of CsA on lymphocytes in cats than in other species.Peripheral blood mononuclear cells (PBMCs) were isolated from 6 healthy cats. PBMCs were exposed to i) no treatment, ii) 5 ...
Source: Veterinary Immunology and Immunopathology - October 26, 2019 Category: Veterinary Research Source Type: research

Serum and salivary adiponectin dynamics in septic and non-septic systemic inflammation in a canine model
Publication date: Available online 25 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Roman Dąbrowski, Anna Wdowiak, Maria D. Contreras-Aguilar, Lorena Franco-Martinez, Alberto Muñoz-Prieto, Marek Szczubiał, Silvia Martinez-Subiela, Jose J. Ceron, Asta TvarijonaviciuteAbstractAdiponectin is a 30 kDa protein hormone that has anti-atherogenic properties, being an insulin-sensitizing and anti-inflammatory molecule. Salivary adiponectin concentrations correlate positively with serum, thus, saliva was indicated as appropriate biofluid for its measurement in different clinical situations. However, in...
Source: Veterinary Immunology and Immunopathology - October 26, 2019 Category: Veterinary Research Source Type: research

A new polymorphic epitope of bovine CD4 antigen evidenced by flow cytometry
Publication date: Available online 17 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Francesco Grandoni, Francesco Napolitano, Maria Carmela Scatà, Giovanna De MatteisAbstractCluster of differentiation 4 (CD4) is the accessory protein non-covalently bounded to T cell receptor (TCR) that recognize an invariant region of MHC class II on antigen presenting cell (APC). Its cytoplasmic tail, physically associated with a protein tyrosine kinase, is important in the activation of helper/inducer T (TH) lymphocytes. The anti-bovine CD4 monoclonal antibody (mAb) CC8 is a clone usefully used in flow cytometr...
Source: Veterinary Immunology and Immunopathology - October 19, 2019 Category: Veterinary Research Source Type: research

Comparison Of Acute Phase Proteins In Different Clinical Classification Systems For Canine Leishmaniosis
Publication date: Available online 14 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Luis Pardo-Marin, Jose J Ceron, Fernando Tecles, Gad Baneth, Silvia Martínez-SubielaAbstractThe main objective of the present study was to evaluate the acute phase protein (APP) concentrations that dogs naturally infected with Leishmania infantum show in different clinical stages of disease staged according to the Leishvet and CLWG classifications. In addition, these classifications are compared with the groups based on APP recommendations published recently.Medical records of 458 dogs with leishmaniosis whose sam...
Source: Veterinary Immunology and Immunopathology - October 15, 2019 Category: Veterinary Research Source Type: research

Oxidative stress pathway gene transcription after bovine respiratory syncytial virus infection in vitro and ex vivo
Publication date: Available online 1 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Amelia R. Hofstetter, Randy E. SaccoAbstractStudies in mouse and lamb models indicate important roles of reactive oxygen species (ROS) in the pathology and immune response to respiratory syncytial virus (RSV). The role of ROS in bovine RSV (BRSV) infection of calves remains unclear. BRSV naturally infects calves, leading to similar disease course, micro- and macro-lesions, and symptomology as is observed in RSV infection of human neonates. Furthermore, humans, lambs, and calves, but not mice, have an active lung oxi...
Source: Veterinary Immunology and Immunopathology - October 3, 2019 Category: Veterinary Research Source Type: research

Phenotypic characterization of immune cells in fetal tissues of cattle immunized and challenged with Neospora caninum
Publication date: Available online 1 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): J.E. Maldonado Rivera, J. DeLay, Y.P. Hecker, M.G. Monterubbianesi, G.J. Cantón, C.M. Campero, A.C. Odeón, D.P. MooreAbstractThe purpose of this work was to characterize the cellular phenotype in inflammatory infiltrates of fetal tissues from pregnant heifers immunized and experimentally challenged with Neospora caninum. Fetuses from 20 heifers separated into 5 groups were obtained. The experiment was designed as follow: Group A, heifers inoculated intravenously with live tachyzoites of Argentine strain NC-6 (n ...
Source: Veterinary Immunology and Immunopathology - October 3, 2019 Category: Veterinary Research Source Type: research

Inflammatory Th17 responses to infection with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle and their potential role in development of Johne’s disease
Publication date: Available online 1 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Justin L. DeKuiper, Paul M. Coussens (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - October 3, 2019 Category: Veterinary Research Source Type: research

Evaluation of immunogenicity and protective efficacy of a CpG-adjuvanted DNA vaccine against Tembusu virus
Publication date: Available online 27 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Hao Chen, Min Yan, Yi Tang, Youxiang DiaoAbstractTembusu virus (TMUV) is a contagious pathogen of waterfowl including ducks and geese, which causes symptoms of high fever, loss of appetite and reduced egg production. The development of an effective vaccine is important for the prevention and control of the disease. We evaluated a DNA vaccine based on a recombinant pre-membrane (prM) and envelope (E) protein, using CpG oligodeoxynucleotide (ODN) as an adjuvanted, and tested it for protection efficacy. BHK21 cells ...
Source: Veterinary Immunology and Immunopathology - September 28, 2019 Category: Veterinary Research Source Type: research

Mycobacterium avium sp. paratuberculosis (MAP) induces IL-17a production in bovine peripheral blood mononuclear cells (PBMCs) and enhances IL-23R expression in-vivo and in-vitro
Publication date: Available online 26 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Justin L. DeKuiper, Paul M. CoussensAbstractJohne’s disease (JD) is a chronic inflammatory gastrointestinal disease of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). Control of JD is difficult largely due to insensitive diagnostic tools, a long subclinical stage of infection, and lack of effective vaccines. Correlates of protection are lacking in model systems of JD and the sources of inflammation due to JD are not well characterized. Commonly studied immune responses, such as the Th...
Source: Veterinary Immunology and Immunopathology - September 27, 2019 Category: Veterinary Research Source Type: research

Effect of allogeneic platelet lysate on equine bone marrow derived mesenchymal stem cell characteristics, including immunogenic and immunomodulatory gene expression profile
In conclusion, the replacement of FBS by allogeneic CPL as a supplement for ex vivo propagation of eBM-MSCs provides appropriate proliferation and cryopreservation, and mildly upregulates the gene expression of immunomodulatory markers, thus constituting a potentially suitable alternative to the use of FBS. Further studies are needed to clarify the composition and effects of CPL supplementation on equine MSCs immunological profile. (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - September 23, 2019 Category: Veterinary Research Source Type: research

Proteomic alteration of porcine intestinal epithelial cells after pretreatment with Lactobacillus plantarum followed by infection with enterotoxigenic Escherichia coli F4
Publication date: Available online 16 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Cui Zhu, Yantao Lv, Jun Yang, Yinshan Bai, Jinling Ye, Zhilin Wang, Zhuang Chen, Zongyong JiangAbstractEnterotoxigenic Escherichia coli (ETEC) F4 causes diarrhea in infants and weaned piglets. The technique of isobaric tags for relative and absolute quantitation (iTRAQ) was used in this study to determine the differentially expressed proteins in porcine intestinal epithelial cells (IPEC-J2) after pretreatment with Lactobacillus plantarum (LP) followed by challenge with ETEC F4. A total of 4,771 proteins were iden...
Source: Veterinary Immunology and Immunopathology - September 18, 2019 Category: Veterinary Research Source Type: research

Characterization of CD79αcy+ cells in placentas from ruminants
Publication date: Available online 13 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Germán J. Cantón, Alex Schock, Noelita Melo de Sousa, Jean-François Beckers, Francesca ChianiniAbstractPrevious work carried out to characterise different immune cells in ruminant placentas found strong CD79αcy nuclear labelling in cells histologically resembling trophoblast cells. In the attempt to characterize this cell population, placentomes collected from cattle, sheep and water buffaloes were examined by immunohistochemistry with single and double labelling using monoclonal antibodies (mAb) against B ly...
Source: Veterinary Immunology and Immunopathology - September 14, 2019 Category: Veterinary Research Source Type: research

Assessing the clinical and bacteriological outcomes of vaccination with recombinant Asp14 and OmpA against A. phagocytophilum in sheep
Publication date: Available online 11 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Sveinung Eskeland, Snorre Stuen, Francy L. Crosby, Kari Lybeck, Anthony F. Barbet, Per-Eric Lindgren, Stig Tollefsen, Peter Wilhelmsson, Tore S. Tollersrud, Shokouh Makvandi-Nejad, Erik G. GranquistAbstractAnaplasma phagocytophilum is a tick borne bacterium, causing disease in sheep and other mammals, including humans. The bacterium has great economic and animal welfare implications for sheep husbandry in Northern Europe. With the prospect of a warmer and more humid climate, the vector availability will likely in...
Source: Veterinary Immunology and Immunopathology - September 12, 2019 Category: Veterinary Research Source Type: research