Trends in Endocrinology and Metabolism 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Acromegaly and Vertebral Fractures: Facts and Questions
Publication date: Available online 13 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Andrea GiustinaHere I review vertebral fractures (VFs) as an emerging complication of acromegaly through a pathway of key questions in order to help clinicians manage the disease. Peculiarities of acromegalic osteopathy are that VFs are common but not explained by low bone mineral density (BMD) being related to disease duration and activity, and occurring even after remission. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - February 14, 2020 Category: Endocrinology Source Type: research
Blood Microbiota and Circulating Microbial Metabolites in Diabetes and Cardiovascular Disease
Publication date: Available online 11 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Ganesan Velmurugan, Vasudevan Dinakaran, Jeyaprakash Rajendhran, Krishnan SwaminathanDiabetes and cardiovascular disease (CVD) have evolved as the leading cause of mortality and morbidity worldwide. In addition to traditional risk factors, recent studies have established that the human microbiota, particularly gut bacteria, plays a role in the development of diabetes and CVD. Although the presence of microbes in blood has been known for centuries, mounting evidence in this metagenomic era provides new insights into the...
Source: Trends in Endocrinology and Metabolism - February 12, 2020 Category: Endocrinology Source Type: research
Debunking the Myth of the Endogenous Antiangiogenic Vegfaxxxb Transcripts
Publication date: Available online 12 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Hugues Dardente, William R. English, Manoj K. Valluru, Chryso Kanthou, David SimpsonIn this opinion article we critically assess evidence for the existence of a family of antiangiogenic vascular endothelial growth factor (Vegfaxxxb) transcripts, arising from the use of a phylogenetically conserved alternative distal splice site within exon 8 of the VEGFA gene. We explain that prior evidence for Vegfaxxxb transcripts in tissues rests heavily upon flawed RT-PCR methodologies, with the extensive use of 5′-tailing in pri...
Source: Trends in Endocrinology and Metabolism - February 12, 2020 Category: Endocrinology Source Type: research
Trained Immunity: Linking Obesity and Cardiovascular Disease across the Life-Course?
Publication date: Available online 8 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Siroon Bekkering, Christoph Saner, Niels P. Riksen, Mihai G. Netea, Matthew A. Sabin, Richard Saffery, Rinke Stienstra, David P. BurgnerObesity, a chronic inflammatory disease, is the most prevalent modifiable risk factor for cardiovascular disease. The mechanisms underlying inflammation in obesity are incompletely understood. Recent developments have challenged the dogma of immunological memory occurring exclusively in the adaptive immune system and show that the innate immune system has potential to be reprogrammed. T...
Source: Trends in Endocrinology and Metabolism - February 10, 2020 Category: Endocrinology Source Type: research
Time for a New Perspective on Prolactin in Metabolism
Publication date: Available online 7 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Yazmín Macotela, Jakob Triebel, Carmen ClappThe pituitary hormone prolactin (PRL) regulates a variety of functions beyond reproduction. The association between physiological (pregnancy) and pathological (prolactinoma) hyperprolactinemia and metabolic alterations led to the concept of this hormone being diabetogenic. However, large cohort clinical studies have recently shown that low circulating PRL levels are associated with metabolic disease and represent a risk factor for type 2 diabetes (T2D), whereas high PRL level...
Source: Trends in Endocrinology and Metabolism - February 8, 2020 Category: Endocrinology Source Type: research
Meditation and Endocrine Health and Wellbeing
Publication date: Available online 6 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Michaela C. Pascoe, David R. Thompson, Chantal F. SkiMeditation is a popular practice for reducing stress and improving mental health and wellbeing. Its effects are mediated largely by the endocrine system, including the hypothalamic–pituitary–adrenal axis, the hypothalamic–pituitary–thyroid axis, and the renin–angiotensin–aldosterone system, and energy homeostasis. The limited evidence available indicates that changes associated with endocrine function following meditation correspond with improvements in me...
Source: Trends in Endocrinology and Metabolism - February 7, 2020 Category: Endocrinology Source Type: research
Glucocorticoid Sexual Dimorphism in Metabolism: Dissecting the Role of Sex Hormones
Publication date: Available online 6 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Jan Kroon, Alberto M. Pereira, Onno C. MeijerGlucocorticoids are steroid hormones that are of pivotal importance in human physiology. Glucocorticoid signaling is complex in nature and dependent on many interacting factors. As glucocorticoids exhibit sexually dimorphic effects on several key processes including in metabolism, crosstalk with the sex steroid hormones (androgens and estrogens) is relevant. In this review, we highlight the state-of-the-art knowledge on glucocorticoid sexual dimorphism and sex hormone crossta...
Source: Trends in Endocrinology and Metabolism - February 7, 2020 Category: Endocrinology Source Type: research
Frozen IVF Cycles to Circumvent the Hormonal Storm on Endometrium
Publication date: Available online 5 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Paola Viganò, Alessandra Alteri, Andrea Busnelli, Valeria Stella Vanni, Edgardo SomiglianaControlled ovarian hyperstimulation (COH) determines an anticipation of endometrial maturation and a premature occurrence of the implantation window, as shown by histological, histochemical, and molecular studies and indirectly by clinical trials. There is growing agreement that in patients hyper-responding to COH and in those undergoing transfer at the blastocyst stage, deferring the transfer in a subsequent frozen cycle could in...
Source: Trends in Endocrinology and Metabolism - February 6, 2020 Category: Endocrinology Source Type: research
Hypothalamic IRX3: A New Player in the Development of Obesity
Publication date: Available online 5 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Thiago Matos de Araújo, Licio A. VellosoGenome-wide association studies (GWASs) have identified SNPs of the fat mass and obesity (FTO) gene as the most important risk alleles for obesity. However, how the presence of risk alleles affect phenotype is still a matter of intense investigation. In 2014, a study revealed that long-range enhancers from the intronic regions of the FTO gene regulate iroquois-class homeobox protein (IRX)3 expression. IRX3 is expressed in hypothalamic pro-opiomelanocortin (POMC) neurons and chang...
Source: Trends in Endocrinology and Metabolism - February 6, 2020 Category: Endocrinology Source Type: research
Mitochondrial Adaptations in the Growing Heart
Publication date: Available online 5 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): María Sánchez-Díaz, José Ángel Nicolás-Ávila, Mario D. Cordero, Andrés HidalgoThe heart pumps blood throughout the whole life of an organism, without rest periods during which to replenish energy or detoxify. Hence, cardiomyocytes, the working units of the heart, have mechanisms to ensure constitutive production of energy and detoxification to preserve fitness and function for decades. Even more challenging, the heart must adapt to the varying conditions of the organism from fetal life to adulthood, old age, and...
Source: Trends in Endocrinology and Metabolism - February 6, 2020 Category: Endocrinology Source Type: research
A Novel Role for CETP as Immunological Gatekeeper: Raising HDL to Cure Sepsis?
Publication date: Available online 4 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Lisanne L. Blauw, Yanan Wang, Ko Willems van Dijk, Patrick C.N. RensenRaising HDL using cholesteryl ester transfer protein (CETP) inhibitors failed to show a clinically relevant risk reduction of cardiovascular disease in clinical trials, inviting reconsideration of the role of CETP and HDL in human physiology. Based on solid evidence from studies with isolated macrophages, rodents, and humans, we propose that a major function of CETP may be to modulate HDL in order to help resolve bacterial infections. When gram-negati...
Source: Trends in Endocrinology and Metabolism - February 5, 2020 Category: Endocrinology Source Type: research
Chronic Diabetes Complications: The Need to Move beyond Classical Concepts
Publication date: Available online 4 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Dídac Mauricio, Núria Alonso, Mònica GratacòsChronic-diabetes-related complications simultaneously compromise both the micro- and macrovascular trees, with target organs considered as the paradigm of large vessel injury also entailing microangiopathic changes. However, complications independent or partially independent from vascular damage are often overlooked. This includes neuronal dysfunction (e.g., retinal neurodegeneration), interstitial injury (e.g., tubulointerstitial disease), metabolic damage (e.g., in the ...
Source: Trends in Endocrinology and Metabolism - February 5, 2020 Category: Endocrinology Source Type: research
Wharton’s Jelly MSCs: Potential Weapon to Sharpen for Our Battle against DM
Publication date: Available online 5 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Dina H. Kassem, Mohamed M. KamalDiabetes mellitus (DM) is a devastating metabolic disease. Stem cell therapy provides great hope to all diabetic patients. Umbilical cord (UC) Wharton’s jelly mesenchymal stem cells (WJ-MSCs) specifically provides a potential cell therapy for DM. In this article, we discuss major advantages of WJ-MSCs and challenges facing their clinical utility in DM. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - February 5, 2020 Category: Endocrinology Source Type: research
Editorial Board and Contents
Publication date: February 2020Source: Trends in Endocrinology & Metabolism, Volume 31, Issue 2Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - January 22, 2020 Category: Endocrinology Source Type: research
Subscription and Copyright Information
Publication date: February 2020Source: Trends in Endocrinology & Metabolism, Volume 31, Issue 2Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - January 22, 2020 Category: Endocrinology Source Type: research
