Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 1, 2014 Category: Cardiology Source Type: research

TCM Editorial Policy
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 1, 2014 Category: Cardiology Source Type: research

Cover 1
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 1, 2014 Category: Cardiology Source Type: research

Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 1, 2014 Category: Cardiology Source Type: research

TCM Editorial Policy
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 1, 2014 Category: Cardiology Source Type: research

Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - April 28, 2014 Category: Cardiology Tags: Frontmatter Source Type: research

Cover 1
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - April 28, 2014 Category: Cardiology Source Type: research

Physiological and pathological functions of NADPH oxidases during myocardial ischemia–reperfusion
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - April 1, 2014 Category: Cardiology Authors: Shouji Matsushima, Hiroyuki Tsutsui, Junichi Sadoshima Source Type: research

Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - April 1, 2014 Category: Cardiology Authors: Shouji Matsushima, Hiroyuki Tsutsui, Junichi Sadoshima Source Type: research

Passing the baton
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 31, 2014 Category: Cardiology Authors: Elizabeth G. Nabel Source Type: research

Accepting the baton
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 31, 2014 Category: Cardiology Source Type: research

Novel roles of hypoxia response system in glucose metabolism and obesity
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 30, 2014 Category: Cardiology Authors: Toshihiro Ichiki, Kenji Sunagawa Source Type: research

TEMPORARY REMOVAL: Passing the Baton
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 28, 2014 Category: Cardiology Authors: Elizabeth G. Nabel Source Type: research

TEMPORARY REMOVAL: Dear Friends and colleagues:
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 28, 2014 Category: Cardiology Authors: Douglas P. Zipes Source Type: research

TEMPORARY REMOVAL: Passing the Baton
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 28, 2014 Category: Cardiology Authors: Elizabeth G. Nabel Source Type: research

TEMPORARY REMOVAL: Dear Friends and colleagues:
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 28, 2014 Category: Cardiology Authors: Douglas P. Zipes Source Type: research

TCM Editorial Policy
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 3, 2014 Category: Cardiology Tags: Frontmatter Source Type: research

Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 3, 2014 Category: Cardiology Tags: Frontmatter Source Type: research

Cover 1- 4c
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - March 3, 2014 Category: Cardiology Source Type: research

Desmosomes and the sodium channel complex: Implications for arrhythmogenic cardiomyopathy and Brugada syndrome
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - February 21, 2014 Category: Cardiology Authors: Marina Cerrone, Mario Delmar Source Type: research

TCM Editorial Policy
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 14, 2014 Category: Cardiology Tags: Frontmatter Source Type: research

Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 14, 2014 Category: Cardiology Tags: Frontmatter Source Type: research

Cover 1-4c
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 14, 2014 Category: Cardiology Source Type: research

TCM Editorial Policy
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 20, 2013 Category: Cardiology Tags: Frontmatter Source Type: research

Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 20, 2013 Category: Cardiology Tags: Frontmatter Source Type: research

Cover 1
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 20, 2013 Category: Cardiology Source Type: research

From GWAS to function: Genetic variation in sodium channel gene enhancer influences electrical patterning
Abstract: The electrical activity of the heart depends on the correct interplay between key transcription factors and cis-regulatory elements, which together regulate the proper heterogeneous expression of genes encoding for ion channels and other proteins. Genome-wide association studies of ECG parameters implicated genetic variants in the genes for these factors and ion channels modulating conduction and depolarization. Here, we review recent insights into the regulation of localized expression of ion channel genes and the mechanism by which a single-nucleotide polymorphism (SNP) associated with alterations in cardiac co...
Source: Trends in Cardiovascular Medicine - December 19, 2013 Category: Cardiology Authors: Malou van den Boogaard, Phil Barnett, Vincent M. Christoffels Tags: Review Articles Source Type: research

Mechanisms of myocardial infarction without obstructive coronary artery disease
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 16, 2013 Category: Cardiology Authors: Harmony R. Reynolds Tags: Review Articles Source Type: research

Mechanisms of myocardial infarction without obstructive coronary artery disease
Abstract: Angiography in patients with myocardial infarction (MI) most commonly reveals one or more significantly narrowed coronary arteries, but a substantial minority of patients with spontaneous MI have no obstructive coronary artery disease (CAD) at angiography. This review summarizes evidence for the most commonly hypothesized mechanisms, including plaque disruption, plaque erosion, vasospasm, embolism, and spontaneous coronary dissection. In addition, tako-tsubo syndrome and myocarditis are discussed. The best treatment of MI without obstructive CAD is likely to differ substantially based on the underlying cause. Add...
Source: Trends in Cardiovascular Medicine - December 16, 2013 Category: Cardiology Authors: Harmony R. Reynolds Tags: Review Articles Source Type: research

Oxidative stress and endothelial dysfunction: Clinical evidence and therapeutic implications
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 5, 2013 Category: Cardiology Authors: Yukihito Higashi, Tatsuya Maruhashi, Kensuke Noma, Yasuki Kihara Tags: Review Articles Source Type: research

Oxidative stress and endothelial dysfunction: Clinical evidence and therapeutic implications
Abstract: An imbalance of nitric oxide (NO) and reactive oxygen species (ROS), so-called “oxidative stress,” may promote endothelial dysfunction, leading to cardiovascular complications. Activation of nicotinamide–adenine dinucleotide phosphate oxidase, xanthine oxidase, cyclooxygenase, and mitochondrial electron transport, inactivation of the antioxidant system, and uncoupling of endothelial NO synthase lead to oxidative stress along with an increase in ROS production and decrease in ROS degradation. Although experimental studies, both in vitro and in vivo, have shown a critical role of oxidative stress ...
Source: Trends in Cardiovascular Medicine - December 5, 2013 Category: Cardiology Authors: Yukihito Higashi, Tatsuya Maruhashi, Kensuke Noma, Yasuki Kihara Tags: Review Articles Source Type: research

Using advanced noninvasive imaging techniques to probe the links between regional coronary artery endothelial dysfunction and atherosclerosis
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 2, 2013 Category: Cardiology Authors: Micaela Iantorno, Robert G. Weiss Tags: Review Articles Source Type: research

Using advanced noninvasive imaging techniques to probe the links between regional coronary artery endothelial dysfunction and atherosclerosis
Abstract: Cardiovascular disease remains the number one cause of death in the US annually. The development in recent years of imaging strategies that can identify coronary endothelial dysfunction noninvasively provides new information about the early presence and local spatial heterogeneity of endothelial function in patients with, and those at risk for, coronary artery disease. In this article, we will briefly review the mechanisms relating endothelial function and atherosclerosis, contemporary imaging strategies now able to quantify coronary endothelial function noninvasively, and recent insights on human coronary endoth...
Source: Trends in Cardiovascular Medicine - December 2, 2013 Category: Cardiology Authors: Micaela Iantorno, Robert G. Weiss Tags: Review Articles Source Type: research

Antioxidant and antiplatelet effects of atorvastatin by Nox2 inhibition
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 20, 2013 Category: Cardiology Authors: Francesco Violi, Roberto Carnevale, Daniele Pastori, Pasquale Pignatelli Tags: Review Articles Source Type: research

Antioxidant and antiplatelet effects of atorvastatin by Nox2 inhibition
Abstract: In recent years, it became evident that reactive oxygen species (ROS) are implicated in the thrombotic process. Statins are lipid-lowering agents able to lower serum cholesterol levels and retard atherosclerotic complications and their clinical sequelae. There is evidence that, among statins, atorvastatin may exert antiplatelet effects by interfering with redox signaling. Recent studies demonstrated that atorvastatin possesses antiplatelet activity via inhibition of platelet formation of NADPH oxidase-derived ROS. This effect results in down-regulation of isoprostanes, which are pro-aggregating molecules, and up-...
Source: Trends in Cardiovascular Medicine - November 20, 2013 Category: Cardiology Authors: Francesco Violi, Roberto Carnevale, Daniele Pastori, Pasquale Pignatelli Tags: Review Articles Source Type: research

The Brugada syndrome revisited
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 13, 2013 Category: Cardiology Authors: Meghavi Mashar, Andrew J. Kwok, Richard Pinder, Ian Sabir Source Type: research

DPP-IV inhibitors: Beyond glycaemic control?
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 4, 2013 Category: Cardiology Authors: Andrew J. Kwok, Meghavi Mashar, Kaivan Khavandi, Ian Sabir Tags: Review Articles Source Type: research

DPP-IV inhibitors: Beyond glycaemic control?
Abstract: Dipeptidyl-peptidase-IV (DPP-IV) inhibitors are a new class of oral hypoglycaemic agents recently approved for the management of type 2 diabetes mellitus. Early data suggested that they had a positive impact on the cardiovascular system: treatment appeared to result in improvements in cardiac performance, blood pressure and lipid levels. However, recent clinical findings bring this into question. Our understanding of the physiological actions of these agents is complicated by the fact that DPP-IV has a wide range of substrates in addition to glucagon-like peptide 1. Indeed, DPP-IV inhibition alters concentrations...
Source: Trends in Cardiovascular Medicine - November 4, 2013 Category: Cardiology Authors: Andrew J. Kwok, Meghavi Mashar, Kaivan Khavandi, Ian Sabir Tags: Review Articles Source Type: research

Lymphatic vessel abnormalities arising from disorders of Ras signal transduction
Abstract: A number of genetic diseases in man have been described in which abnormalities in the development and function of the lymphatic vascular (LV) system are prominent features. The genes that are mutated in these diseases are varied and include genes that encode lymphatic endothelial cell (LEC) growth factor receptors and their ligands and transcription factors that control LEC fate and function. In addition, an increasing number of genes have been identified that encode components of the Ras signal transduction pathway that conveys signals from cell surface receptors to regulate cell growth, proliferation, and diffe...
Source: Trends in Cardiovascular Medicine - November 4, 2013 Category: Cardiology Authors: Eva M. Sevick-Muraca, Philip D. King Tags: Review Articles Source Type: research

Reactive oxygen at the heart of metabolism
We describe here the metabolic changes that occur in the developing heart and how they can revert in cardiopathologies. They are discussed in the light of what is currently known about the regulation of these processes by changes in the cellular redox state and levels of ROS production. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 4, 2013 Category: Cardiology Authors: Thomas V.A. Murray, Aminah Ahmad, Alison C. Brewer Tags: Review Articles Source Type: research

Role of miR-181 family in regulating vascular inflammation and immunity
Abstract: The microRNA family, miR-181, plays diverse roles in regulating key aspects of cellular growth, development, and activation. Accumulating evidence supports a central role for the miR-181 family in vascular inflammation by controlling critical signaling pathways, such as downstream NF-κB signaling, and targets relevant to endothelial cell activation and immune cell homeostasis. This review examines the current knowledge of the miR-181 family's role in key cell types that critically control cardiovascular inflammation under pathological and physiological stimuli. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 4, 2013 Category: Cardiology Authors: Xinghui Sun, Alan Sit, Mark W. Feinberg Tags: Review Articles Source Type: research