Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development
For decades, scientists have been using two-dimensional cell culture platforms for high-throughput drug screening of anticancer drugs. Growing evidence indicates that the results of anti-cancer drug screening vary with the cell culture microenvironment, and this variation has been proposed as a reason for the high failure rate of clinical trials. Since the culture condition-dependent drug sensitivity of anti-cancer drugs may negatively impact the identification of clinically effective drug candidates, more reliable in vitro cancer platforms are urgently needed. In this review article, we provide an overview of how cell cul...
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yeonho Jo, Nakwon Choi, Kyobum Kim, Hyung-Jun Koo, Jonghoon Choi, Hong Nam Kim Tags: Review Source Type: research

Increasing lean muscle mass in mice via nanoparticle-mediated hepatic delivery of follistatin mRNA
Conclusion: Based on the obtained results demonstrating an increased muscle mass as well as restricted fat accumulation, this nanoplatform might be a milestone in the development of mRNA technologies and the treatment of muscle wasting disorders. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Canan Schumann, Duc X. Nguyen, Mason Norgard, Yulia Bortnyak, Tetiana Korzun, Stephanie Chan, Anna St. Lorenz, Abraham S. Moses, Hassan A. Albarqi, Leon Wong, Katherine Michaelis, Xinxia Zhu, Adam W. G. Alani, Olena R. Taratula, Stephanie Krasnow, Daniel Tags: Research Paper Source Type: research

MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance
Conclusion: MICAL2 binds to p53, retains p53 in the cytoplasm and oxidizes it at Met 40 and 160, promotes p53 ubiquitination, and decreases p53 function. MICAL2-reduced p53 promotes CRC development. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Jinping Lu, Yuejin Li, Yuanzhong Wu, Shan Zhou, Chaojun Duan, Zigang Dong, Tiebang Kang, Faqing Tang Tags: Research Paper Source Type: research

EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers
Epstein-Barr virus (EBV) infects more than 90% of humans worldwide and establishes lifelong latent infection in the hosts. It is closely associated with endemic forms of a wide range of human cancers and directly contributes to the formation of some. Despite its critical role in cancer development, no EBV- or EBV latent protein-targeted therapy is available. The EBV-encoded latent protein, Epstein-Barr nuclear antigen 1 (EBNA1), is expressed in all EBV-associated tumors and acts as the only latent protein in some of these tumors. This versatile protein functions in the maintenance, replication, and segregation of the EBV g...
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Lijun Jiang, Chen Xie, Hong Lok Lung, Kwok Wai Lo, Ga-Lai Law, Nai-Ki Mak, Ka-Leung Wong Tags: Review Source Type: research

Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery
Conclusion: The present study not only sheds light on the development of AuNP-DPA as a novel class of antitumor agents for drugging the p53 pathway in vivo, but also supplies a new strategy to use D-peptides as intracellular PPI inhibitors for cancer-targeted therapy. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Zhenyuan Bian, Jin Yan, Simeng Wang, Yijie Li, Yi Guo, Bohan Ma, Hao Guo, Zhijie Lei, Chun Yin, Yi Zhou, Min Liu, Kaishan Tao, Peng Hou, Wangxiao He Tags: Research Paper Source Type: research

Recommendations for reporting on emerging optical imaging agents to promote clinical approval
Intraoperative fluorescence imaging is particularly well-suited for surgical applications due to its inherently high sensitivity, resolution, and ability to provide images in real-time. To date, the intraoperative observation of fluorescence has largely been subjective. With the need to show objective evidence in order to demonstrate the benefit of this technique, quantitative data needs to be provided to overseeing regulatory bodies. Standardization of fluorescence imaging protocols would improve reproducibility and minimize inter- and intra-institution variance. This would allow studies to be conducted using the same inj...
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Willemieke S. Tummers, Jason M Warram, Nynke S. van den Berg, Sarah E. Miller, Rutger-Jan Swijnenburg, Alexander L. Vahrmeijer, Eben L. Rosenthal Tags: Review Source Type: research

Prostaglandin E2 hydrogel improves cutaneous wound healing via M2 macrophages polarization
Conclusion: Our findings highlight the potential of the CS+PGE2 hydrogel as a novel therapeutic strategy for promoting tissue regeneration via M2 macrophage polarization. Moreover, molecular imaging provides a platform for monitoring cellular and molecular events in real-time during tissue repair and facilitates the discovery of optimal therapeutics for injury repair by regulating the balance of cytokines and mediators at injured sites. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Shuaiqiang Zhang, Yuanyuan Liu, Xin Zhang, Dashuai Zhu, Xin Qi, Xiaocang Cao, Yihu Fang, Yongzhe Che, Zhong-Chao Han, Zuo-Xiang He, Zhibo Han, Zongjin Li Tags: Research Paper Source Type: research

A Biomimetic Gold Nanocages-Based Nanoplatform for Efficient Tumor Ablation and Reduced Inflammation
Conclusion: This biomimetic AuNCs-based platform might be a prospective drug delivery system for precision PTT and chemotherapy, acquiring desired cancer treatment efficacy and low inflammatory response. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Qingbo Xu, Jiangshan Wan, Nana Bie, Xianlin Song, Xiaoquan Yang, Tuying Yong, Yanbing Zhao, Xiangliang Yang, Lu Gan Tags: Research Paper Source Type: research

V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis
Vacuolar ATPases (V-ATPases) play a critical role in regulating extracellular acidification of osteoclasts and bone resorption. The deficiencies of subunit a3 and d2 of V-ATPases result in increased bone density in humans and mice. One of the traditional drug design strategies in treating osteoporosis is the use of subunit a3 inhibitor. Recent findings connect subunits H and G1 with decreased bone density. Given the controversial effects of ATPase subunits on bone density, there is a critical need to review the subunits of V-ATPase in osteoclasts and their functions in regulating osteoclasts and bone remodeling. In this re...
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Xiaohong Duan, Shaoqing Yang, Lei Zhang, Tielin Yang Tags: Review Source Type: research

Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state
Conclusion: This study provides new translational targets for PET tracers for the anti-inflammatory/protective activation state of microglia and shows the potential of a rationale-based approach. It therefore paves the way for the development of novel non-invasive methodologies aimed to monitor the success of therapeutic approaches in various neurological diseases. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Alessandro Villa, Barbara Klein, Bieneke Janssen, Jordi Pedragosa, Giovanna Pepe, Bastian Zinnhardt, Danielle J. Vugts, Paolo Gelosa, Luigi Sironi, Wissam Beaino, Annelaure Damont, Fr é d é ric Doll é , Benoit Jego, Alexandra Winkeler, Dieter Ory, Olof Tags: Research Paper Source Type: research

Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking
Conclusion: We demonstrate that CS triggers the modification of exosome components and identify miR-21 derived from bronchial epithelial cells as a mediator of myofibroblast differentiation through the pVHL/HIF-1α signaling pathway, which has potential value for diagnosis and treatment of COPD. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Hui Xu, Min Ling, Junchao Xue, Xiangyu Dai, Qian Sun, Chao Chen, Yi Liu, Liang Zhou, Jianping Liu, Fei Luo, Qian Bian, Qizhan Liu Tags: Research Paper Source Type: research

Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway
Conclusion: These results indicated that TLR4-dependent autophagy regulates microglial polarization and induces ischemic white matter damage via STAT1/6 pathway. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Chuan Qin, Qian Liu, Zi-Wei Hu, Luo-Qi Zhou, Ke Shang, Dale B. Bosco, Long-Jun Wu, Dai-Shi Tian, Wei Wang Tags: Research Paper Source Type: research

Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming
Conclusion: Elevated expression of PITPNC1 in GC is correlated with an advanced clinical stage and a poor prognosis. PITPNC1 promotes anoikis resistance through enhanced FAO, which is regulated by omental adipocytes and consequently facilitates GC omental metastasis. Targeting PITPNC1 might present a promising strategy to treat omental metastasis. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yujing Tan, Kelin Lin, Yang Zhao, Qijing Wu, Dongping Chen, Jin Wang, Yanxiao Liang, Jingyu Li, Jiazhu Hu, Hao Wang, Yajing Liu, Shuyi Zhang, Wanming He, Qiong Huang, Xingbin Hu, Zhiqi Yao, Bishan Liang, Wangjun Liao, Min Shi Tags: Research Paper Source Type: research

“ Cell-addictive ” dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway
Conclusion: Due to their low price, simple preparation, safety, and excellent therapeutic effect on PD, B6ME-NPs are expected to have potential application in PD treatment. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: YanHui Li, ZiXuan Chen, ZhiGuo Lu, QingHu Yang, LinYing Liu, ZhaoTan Jiang, LiQun Zhang, Xin Zhang, Hong Qing Tags: Research Paper Source Type: research

Development of an Accurate and Proactive Immunomodulatory Strategy to Improve Bone Substitute Material-Mediated Osteogenesis and Angiogenesis
Conclusions: Accurate immunomodulation via IL4 delivery significantly enhanced DBM-mediated osteogenesis and angiogenesis via the coordinated involvement of M1 and M2 macrophages, revealing the promise of this accurate and proactive immunomodulatory strategy for developing new bone substitute materials. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Zhi-wei Zheng, Ya-hong Chen, Ding-yu Wu, Jin-bing Wang, Ming-ming Lv, Xian-song Wang, Jian Sun, Zhi-Yong Zhang Tags: Research Paper Source Type: research

Self-assembly of porphyrin-grafted lipid into nanoparticles encapsulating doxorubicin for synergistic chemo-photodynamic therapy and fluorescence imaging
Conclusion: In summary, the PGL-DOX NPs combined chemo-photodynamic nanoplatform may serve as a potential candidate for cancer theranostics. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Sadaf Hameed, Pravin Bhattarai, Xiaolong Liang, Nisi Zhang, Yunxue Xu, Min Chen, Zhifei Dai Tags: Research Paper Source Type: research

Injection of Adipose-Derived Stromal Cells in the Knee of Patients with Severe Osteoarthritis has a Systemic Effect and Promotes an Anti-Inflammatory Phenotype of Circulating Immune Cells
Conclusion: ASCs may drive an immediate local response by releasing paracrine factors and cytokines, and our results suggest that ASCs could also initiate a cascade resulting in a long-lasting systemic immune modulation. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yves-Marie Pers, Julie Quentin, Rosanna Feirreira, Francisco Espinoza, Naoill Abdellaoui, Nejla Erkilic, Ma ï lys Cren, Emilie Dufourcq-Lopez, Oliver Pullig, Ulrich N ö th, Christian Jorgensen, Pascale Louis-Plence Tags: Research Paper Source Type: research

Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics
Conclusion: D-NAC has shown promising efficacy in many animal models of neurodegeneration, and this work provides evidence that modification for mitochondrial targeting can further enhance its therapeutic efficacy, particularly in diseases where oxidative stress-induced glial cell death plays a significant role in disease progression. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Anjali Sharma, Kevin Liaw, Rishi Sharma, Zhi Zhang, Sujatha Kannan, Rangaramanujam M. Kannan Tags: Research Paper Source Type: research

Verification of Long-Term Genetic Stability of hMSCs during Subculture after Internalization of Sunflower-Type Nanoparticles (SF-NPs)
Conclusion: The QD nanogels used in this study, did not affect genome integrity during long-term subculture, and are thus suitable for multiple theranostic applications. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Ji Sun Park, Se Won Yi, Hye Jin Kim, Hyun Jyung Oh, Jung Sun Lee, Minyeon Go, Sung Han Shim, Keun-Hong Park Tags: Research Paper Source Type: research

Novel spheroid reservoir bioartificial liver improves survival of nonhuman primates in a toxin-induced model of acute liver failure
Conclusions: The benefit of SRBAL therapy included preventive effects and therapeutic effects. SRBAL improved survival rate and prolonged median survival time in a nonhuman primate model of drug-induced ALF, and these benefits declined with a delay in the initiation of therapy. Improved survival and recovery of ALF monkeys was associated with a reduction in blood ammonia levels, inhibition of the pro-inflammatory response of ALF, and provided a microenvironment more suitable for regeneration of the injured liver. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yi Li, Qiong Wu, Yujia Wang, Chengxin Weng, Yuting He, Mengyu Gao, Guang Yang, Li Li, Fei Chen, Yujun Shi, Bruce P. Amiot, Scott L. Nyberg, Ji Bao, Hong Bu Tags: Research Paper Source Type: research

Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3 β Complex in Hypophosphatasia
Conclusion: Based on our findings, TNSALP acts as a signal regulator to control lineage switching of BMMSCs by regulating the LRP6/GSK3β cascade. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Wenjia Liu, Liqiang Zhang, Kun Xuan, Chenghu Hu, Liya Li, Yongjie Zhang, Fang Jin, Yan Jin Tags: Research Paper Source Type: research

miR-125a-5p ameliorates hepatic glycolipid metabolism disorder in type 2 diabetes mellitus through targeting of STAT3
Conclusions: Our results confirmed that miR-125a-5p should be considered as a regulator of glycolipid metabolism in T2DM, which can inhibit hepatic lipogenesis and gluconeogenesis and elevate glycogen synthesis by targeting STAT3. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Lina Xu, Yue Li, Lianhong Yin, Yan Qi, Huijun Sun, Pengyuan Sun, Ming Xu, Zeyao Tang, Jinyong Peng Tags: Research Paper Source Type: research

Longitudinal intravital imaging of transplanted mesenchymal stem cells elucidates their functional integration and therapeutic potency in an animal model of interstitial cystitis/bladder pain syndrome
Conclusion: This longitudinal bioimaging study of transplanted hESC-derived M-MSCs in living animals reveals their long-term functional integration, which underlies the improved therapeutic effects of these cells on IC/BPS. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Chae-Min Ryu, Hwan Yeul Yu, Hye-Yeon Lee, Jung-Hyun Shin, Seungun Lee, Hyein Ju, Bjorn Paulson, Sanghwa Lee, Sujin Kim, Jisun Lim, Jinbeom Heo, Ki-Sung Hong, Hyung-Min Chung, Jun Ki Kim, Dong-Myung Shin, Myung-Soo Choo Tags: Research Paper Source Type: research

Cascaded Electrochemiluminescence Signal Amplifier for the Detection of Telomerase Activity from Tumor Cells and Tissues
Conclusion: This cascaded ECL signal amplifier has the potential to be a technological innovation in the field of telomerase activity detection. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Zhaoyan Zhao, Qingqin Tan, Xiaoxia Zhan, Jingyan Lin, Zhijin Fan, Keng Xiao, Bing Li, Yuhui Liao, Xi Huang Tags: Research Paper Source Type: research

Engineered RNase P Ribozymes Effectively Inhibit the Infection of Murine Cytomegalovirus in Animals
Conclusions: Our results provide the first direct evidence that novel engineered RNase P ribozyme variants with more active catalytic activity in vitro are also more effective in inhibiting viral gene expression in animals. Moreover, our studies imply the potential of engineering novel RNase P ribozyme variants with unique mutations to improve ribozyme activity for therapeutic application. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Wei Li, Yujun Liu, Yuanyuan Wang, Ruilin Li, Phong Trang, Wei Tang, Zhu Yang, Yu Wang, Xu Sun, Xiwen Xing, Sangwei Lu, Fenyong Liu Tags: Research Paper Source Type: research

In vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis
Conclusion: Dextran-Catechin mediates its activity by lowering CTR1 and intracellular copper levels in tumors. This finding further reveals a potential therapeutic strategy for targeting copper-dependent cancers and presents a novel PET imaging method to assess patient response to copper-targeting anticancer treatments. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Arvind Parmar, Giancarlo Pascali, Florida Voli, Luigi Lerra, Eugene Yee, Aria Ahmed-Cox, Kathleen Kimpton, Giuseppe Cirillo, Andrew Arthur, David Zahra, Gita Rahardjo, Guo Jun Liu, Nigel Lengkeek, Federica Saletta, Arnaud Charil, Maria Kavallaris, Orazio Tags: Research Paper Source Type: research

In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell: Erratum
(Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Kuan Hu, Feng Yin, Mengyin Yu, Chengjie Sun, Jingxu Li, Yujie Liang, Wenjun Li, Mingsheng Xie, Yuanzhi Lao, Wei Liang, Zi-gang Li Tags: Erratum Source Type: research

In vivo Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy
Conclusion: Our findings demonstrate that this novel nanoplatform for targeted image-guided treatment of tumor and tactfully integrated chemotherapy, photothermal therapy (PTT) and gene therapy might provide an insight for cancer theranostics. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Cheng Li, Xiao-Quan Yang, Ming-Zhen Zhang, Yuan-Yang Song, Kai Cheng, Jie An, Xiao-Shuai Zhang, Yang Xuan, Bo Liu, Yuan-Di Zhao Tags: Research Paper Source Type: research

Long non-coding RNA DANCR stabilizes HIF-1 α and promotes metastasis by interacting with NF90/NF45 complex in nasopharyngeal carcinoma
Conclusions: Taken together, our results suggest that DANCR acts as a prognostic biomarker and increases HIF-1α mRNA stability by interacting with NF90/NF45, leading to metastasis and disease progression of NPC. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Xin Wen, Xu Liu, Yan-Ping Mao, Xiao-Jing Yang, Ya-Qin Wang, Pan-Pan Zhang, Yuan Lei, Xiao-Hong Hong, Qing-Mei He, Jun Ma, Na Liu, Ying-Qin Li Tags: Research Paper Source Type: research

Clinical significance of PD-1/PD-Ls gene amplification and overexpression in patients with hepatocellular carcinoma
Conclusions: Amplification or higher expression of PD-L1 significantly and independently correlated with unfavorable survival in HCC patients, authenticating the PD-1/PD-L1 axis as rational immunotherapeutic targets for HCC. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Li-Jie Ma, Fei-Ling Feng, Liang-Qing Dong, Zhao Zhang, Meng Duan, Long-Zi Liu, Jie-Yi Shi, Liu-Xiao Yang, Zhi-Chao Wang, Shu Zhang, Zhen-Bin Ding, Ai-Wu Ke, Ya Cao, Xiao-Ming Zhang, Jian Zhou, Jia Fan, Xiao-Ying Wang, Qiang Gao Tags: Research Paper Source Type: research

Use of a pre-vascularised oral mucosal cell sheet for promoting cutaneous burn wound healing
Conclusions: The pre-vascularised mucosal cell sheet promotes cutaneous burn wound healing. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Jaewang Lee, Daiha Shin, Jong-Lyel Roh Tags: Research Paper Source Type: research

Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy
This study aims to investigate whether caffeine, a well-known purine alkaloid, is able to prevent skin from oxidative stress-induced senescence, and to explore the underlying molecular mechanisms.Methods: A free radical inducer 2,2'-Azobis (2-amidinopropane) dihydrochloride (AAPH) was used to induce oxidative stress and cellular senescence in both transformed skin cells and in normal human epidermal keratinocytes (NHEKs). Ultraviolet (UV) irradiation was established as the in vivo oxidative stress model in mouse skin tissues. Cellular senescence was determined by SA β-galactosidase staining, immunofluorescence and wes...
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yi-Fang Li, Shu-Hua Ouyang, Long-Fang Tu, Xi Wang, Wei-Lin Yuan, Guo-En Wang, Yan-Ping Wu, Wen-Jun Duan, Hong-Min Yu, Zhong-Ze Fang, Hiroshi Kurihara, Youwei Zhang, Rong-Rong He Tags: Research Paper Source Type: research

Spatial-Temporal Cellular Bioeffects from Acoustic Droplet Vaporization
Conclusion: This study provide new insights into the ADV-mediated physicochemical synergic effect for medical applications. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Ching-Hsiang Fan, Yi-Ting Lin, Yi-Ju Ho, Chih-Kuang Yeh Tags: Research Paper Source Type: research

A Positive Feedback Loop of SLP2 Activates MAPK Signaling Pathway to Promote Gastric Cancer Progression
Conclusion: Our findings demonstrated a positive feedback loop of SLP2 which leads to acceleration of tumor progression and poor survival of GC patients. This finding also provided evidence for the reason of SLP2 elevation. Moreover, we found that sorafenib might be a potential therapeutic drug for GC and disrupting the interaction between SLP2 and PHB might also serve as a potential therapeutic target in GC. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Wenhui Ma, Zhuoluo Xu, Yutian Wang, Wenyi Li, Zhigang Wei, Tao Chen, Tingyu Mou, Mingzhen Cheng, Jun Luo, Tingyue Luo, Yuehong Chen, Jiang Yu, Weijie Zhou, Guoxin Li Tags: Research Paper Source Type: research

Virtual stenting with simplex mesh and mechanical contact analysis for real-time planning of thoracic endovascular aortic repair
This study developed a fast virtual stenting algorithm to simulate stent-induced aortic remodeling to assist in real-time thoracic endovascular aortic repair planning.Methods: The virtual stenting algorithm was established based on simplex deformable mesh and mechanical contact analysis. The key parameters of the mechanical contact analysis were derived from mechanical tests on aortic tissue (n=40) and commonly used stent-grafts (n=6). Genetic algorithm was applied to select weighting parameters. Testing and validation of the algorithm were performed using pre- and post-treatment computed tomography angiography datasets of...
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Duanduan Chen, Jianyong Wei, Yiming Deng, Huanming Xu, Zhenfeng Li, Haoye Meng, Xiaofeng Han, Yonghao Wang, Jia Wan, Tianyi Yan, Jiang Xiong, Xiaoying Tang Tags: Research Paper Source Type: research

An Aptamer-Based Probe for Molecular Subtyping of Breast Cancer
Conclusion: The results suggest that the aptamer-based probe is a powerful tool for fast and highly sensitive subtyping of breast cancer both in vitro and in vivo and is also very promising for the identification, diagnosis, and targeted therapy of breast cancer molecular subtypes. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Mei Liu, Zhifei Wang, Ting Tan, Zhongsi Chen, Xianbo Mou, Xiaocheng Yu, Yan Deng, Guangming Lu, Nongyue He Tags: Research Paper Source Type: research

Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?
The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer. Utilization of ACT can enhance the function of the immune system or improve the specificity and persistence of transferred cells. Various immune cells including T lymphocytes, natural killer cells, dendritic cells, and even stem cells can be used in the ACT despite their different functional mechanisms. Colorectal cancer (CRC) is among the most common malignancies and causes millions of deaths worldwide every year. In this review, we d...
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Jiaqiao Fan, Dong Shang, Bing Han, Jianxun Song, Hailong Chen, Jin-Ming Yang Tags: Review Source Type: research

miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/ β -Catenin Axis
Conclusions: Our results indicated that miR-200c/141 played biphasic roles in breast tumor progression via affecting the BCSC heterogeneity, suggesting targeting BCSC heterogeneity to simultaneously restrict breast cancer initiation and metastasis could be a promising therapeutic strategy for breast cancer. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Bingjie Liu, Ruikai Du, Lei Zhou, Jiahui Xu, Song Chen, Ji Chen, Xiaoli Yang, Dong-xu Liu, Zhi-ming Shao, Lixing Zhang, Zuoren Yu, Ni Xie, Jun-lin Guan, Suling Liu Tags: Research Paper Source Type: research

A heparan sulfate-based matrix therapy reduces brain damage and enhances functional recovery following stroke
Conclusion: HSm represent a promising ECM-based therapeutic strategy to protect and repair the brain after a stroke and favor functional recovery. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yacine Khelif, J é r ô me Toutain, Marie-Sophie Quittet, Sandrine Chantepie, Xavier Laffray, Samuel Valable, Didier Divoux, Fernando Sineriz, Emanuelle Pascolo-Rebouillat, Dulce Papy-Garcia, Denis Barritault, Omar Touzani, Myriam Bernaudin Tags: Research Paper Source Type: research

Remote loading of liposomes with a 124I-radioiodinated compound and their in vivo evaluation by PET/CT in a murine tumor model
Conclusion: The lower accumulation was interpreted as release of the tracer from the liposomes within these organs after accumulation. These results may guide the design of systems for controlled release of remote loadable drugs from liposomes. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Gokce Engudar, Henrik Schaarup-Jensen, Frederikke P. Fliedner, Anders E. Hansen, Paul Kempen, Rasmus I. J ø lck, Andreas Kj æ er, Thomas L. Andresen, Mads H. Clausen, Andreas I. Jensen, Jonas R. Henriksen Tags: Research Paper Source Type: research

Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
Conclusion: Overall, this research shows how powerful complementary single cell analytical approaches can be used to improve our understanding of drug action in vivo. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Sean P. Arlauckas, Seth B. Garren, Chris S. Garris, Rainer H. Kohler, Juhyun Oh, Mikael J. Pittet, Ralph Weissleder Tags: Research Paper Source Type: research

A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p
Conclusions: Our findings reveal a novel regulatory pathway that comprises circNCX1, miR-133a-3p and CDIP1, that is involved in cardiomyocyte apoptosis. This pathway may serve as a potential therapeutic avenue for ischemic heart diseases. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Mengyang Li, Wei Ding, Muhammad Akram Tariq, Wenguang Chang, Xuejuan Zhang, Wenhua Xu, Lin Hou, Yifei Wang, Jianxun Wang Tags: Research Paper Source Type: research

Radiation-responsive scintillating nanotheranostics for reduced hypoxic radioresistance under ROS/NO-mediated tumor microenvironment regulation
Conclusion: This work demonstrates the great potential of scintillating nanotheranostics for multimodal imaging-guided X-ray radiation-triggered tumor combined therapy to overcome radioresistance. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yan Dou, Yajuan Liu, Fangshi Zhao, Yanyan Guo, Xue Li, Menglin Wu, Jin Chang, Chunshui Yu Tags: Research Paper Source Type: research

BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1
Conclusion: Our data indicated that BPI-9016M is an effective agent against lung adenocarcinoma, particularly in tumors with c-Met activation, and likely functions through upregulation of miR203 leading to reduced DKK1 expression. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Panpan Zhang, Shaolei Li, Chao Lv, Jiahui Si, Ying Xiong, Lieming Ding, Yuanyuan Ma, Yue Yang Tags: Research Paper Source Type: research

Dual-Modality ImmunoPET/Fluorescence Imaging of Prostate Cancer with an Anti-PSCA Cys-Minibody
Conclusion: Dual-labeled A11 cMb specifically visualized PSCA-positive tumor by successive immunoPET/fluorescence, which can potentially be translated for preoperative whole-body prostate cancer detection and intraoperative surgical guidance in patients. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Wenting K Tsai, Kirstin A Zettlitz, Richard Tavar é , Naoko Kobayashi, Robert E Reiter, Anna M Wu Tags: Research Paper Source Type: research

Radiomic signature of 18F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits
Conclusion: The newly developed radiomic signature was a powerful predictor of OS and DFS. Moreover, the radiomic signature could predict which patients could benefit from chemotherapy. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yuming Jiang, Qingyu Yuan, Wenbing Lv, Sujuan Xi, Weicai Huang, Zepang Sun, Hao Chen, Liying Zhao, Wei Liu, Yanfeng Hu, Lijun Lu, Jianhua Ma, Tuanjie Li, Jiang Yu, Quanshi Wang, Guoxin Li Tags: Research Paper Source Type: research

Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated blood-brain barrier preservation
Conclusion: Taken together, this study suggests that overexpression of CCR2 on MSCs enhances their targeted migration to the ischemic hemisphere and improves the therapeutic outcomes, which is attributed to the PRDX4-mediated BBB preservation. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Yinong Huang, Jiancheng Wang, Jianye Cai, Yuan Qiu, Haiqing Zheng, Xiaofan Lai, Xin Sui, Yi Wang, Qiying Lu, Yanan Zhang, Meng Yuan, Jin Gong, Wei Cai, Xin Liu, Yilong Shan, Zhezhi Deng, Yue Shi, Yaqing Shu, Lei Zhang, Wei Qiu, Lisheng Peng, Jie Ren, Zhen Tags: Research Paper Source Type: research

Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin
Conclusion: Our findings suggest a novel gut-brain dialogue through intestinal benzoic acid for the treatment of depression and reveal that the gut microbiota may play a causal role in the pathogenesis and treatment of the central nervous system disease. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Zhen-Xiong Zhao, Jie Fu, Shu-Rong Ma, Ran Peng, Jin-Bo Yu, Lin Cong, Li-Bin Pan, Zuo-Guang Zhang, Hui Tian, Chun-Tao Che, Yan Wang, Jian-Dong Jiang Tags: Research Paper Source Type: research

Islet α -cell Inflammation Induced By NF- κ B inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice
Conclusions: Islet α-cell specific overexpression of NIK results in islet α-cell dysfunction and causes islet β-cell death and pancreatitis, which are most likely due to paracrine secretion of cytokines and chemokines from islet α cells, thus leading to hypoglycemia, growth retardation, and postnatal death in mice. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Xinzhi Li, Linna Jia, Xiaoyue Chen, Ying Dong, Xiaomeng Ren, Yuefan Dong, Ying Chen, Liwei Xie, Ming Liu, Chiyo Shiota, George K. Gittes, Liangyou Rui, Zheng Chen Tags: Research Paper Source Type: research

Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis
Conclusion: Our results show that classical monocytes play a critical role in arthritis bone erosion. They demonstrate the theranostics potential of manipulating miR-146a expression in Ly6Chigh monocytes to prevent joint destruction while sparing inflammation in arthritis. (Source: Theranostics)
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Meryem Ammari, Jessy Presumey, Clara Ponsolles, Gautier Roussignol, Christine Roubert, Virginie Escriou, Karine Toupet, Anne-Laure Mausset-Bonnefont, Ma ï lys Cren, Maxime Robin, Philippe Georgel, Ramzi Nehmar, Leonie Taams, Joachim Gr ü n, Andrea Gr ü Tags: Research Paper Source Type: research