A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models
Conclusions: The PROTAC (C004019) created in the current study can selectively and efficiently promote tau clearance both in vitro and in vivo, which provides a promising drug candidate for AD and the related tauopathies. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Weijin Wang, Qiuzhi Zhou, Tao Jiang, Shihong Li, Jinwang Ye, Jie Zheng, Xin Wang, Yanchao Liu, Minmin Deng, Dan Ke, Qun Wang, Yipeng Wang, Jian-Zhi Wang Tags: Research Paper Source Type: research
Role of serotonin receptor signaling in cancer cells and anti-tumor immunity
Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter known to affect emotion, behavior, and cognition, and its effects are mostly studied in neurological diseases. The crosstalk between the immune cells and the nervous system through serotonin and its receptors (5-HTRs) in the tumor microenvironment and the secondary lymphoid organs are known to affect cancer pathogenesis. However, the molecular mechanism of - alteration in the phenotype and function of - innate and adaptive immune cells by serotonin is not well explored. In this review, we discuss how serotonin and serotonin receptors modulate the phenotype and f...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Surojit Karmakar, Girdhari Lal Tags: Review Source Type: research
Deep-learning and MR images to target hypoxic habitats with evofosfamide in preclinical models of sarcoma
Conclusion: Artificial intelligence analysis of pre-therapy MR images can predict hypoxia and subsequent response to HAPs. This approach can be used to monitor therapy response and adapt schedules to forestall the emergence of resistance. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Bruna V. Jardim-Perassi, Wei Mu, Suning Huang, Michal R. Tomaszewski, Jan Poleszczuk, Mahmoud A. Abdalah, Mikalai M. Budzevich, William Dominguez-Viqueira, Damon R. Reed, Marilyn M. Bui, Joseph O. Johnson, Gary V. Martinez, Robert J. Gillies Tags: Research Paper Source Type: research
CD45RO-CD8+ T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ER β /miR-765/PLP2/Notch axis
Conclusions: This observation reveals novel molecular mechanisms underlying estrogen signaling and CD8+ T cell-released exosomes in UCEC development, and provides a potential therapeutic strategy for UCEC patients with aberrant ERβ/miR-765/PLP2/Notch signaling axis. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Wen-Jie Zhou, Jie Zhang, Feng Xie, Jiang-Nan Wu, Jiang-Feng Ye, Jian Wang, Ke Wu, Ming-Qing Li Tags: Research Paper Source Type: research
An integrated epigenomic-transcriptomic landscape of lung cancer reveals novel methylation driver genes of diagnostic and therapeutic relevance
Conclusions: We discovered several novel methylation driver genes of diagnostic and therapeutic relevance in lung cancer. Our findings revealed that DNA methylation in TF binding motifs regulates target gene expression by affecting the binding ability of TFs. Our study also provides a valuable epigenetic resource for identifying DNA methylation-based diagnostic biomarkers, developing cancer drugs for epigenetic therapy and studying cancer pathogenesis. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiwei Sun, Jiani Yi, Juze Yang, Yi Han, Xinyi Qian, Yi Liu, Jia Li, Bingjian Lu, Jisong Zhang, Xiaoqing Pan, Yong Liu, Mingyu Liang, Enguo Chen, Pengyuan Liu, Yan Lu Tags: Research Paper Source Type: research
Turning cold tumors into hot tumors by improving T-cell infiltration
We present a critical review of our understanding of the mechanisms underlying “cold tumors”, including impaired T-cell priming and deficient T-cell homing to tumor beds. “Hot tumors” with significant T-cell infiltration are associated with better ICI efficacy. In this review, we summarize multiple strategies that promote the transformation of "cold tumors" into “hot tumors” and discuss the mechanisms by which these strategies lead to increased T-cell infiltration. Finally, we discuss the application of nanomaterials to tumor immunotherapy and provide an outlook on the future of ...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yuan-Tong Liu, Zhi-Jun Sun Tags: Review Source Type: research
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
Conclusion: Taken together, our study revealed a PRMT1-dependent epigenetic mechanism in the control of ccRCC tumor growth and drug resistance, indicating PRMT1 may serve as a promising target for therapeutic intervention in ccRCC patients. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jianfeng Wang, Chen Wang, Pan Xu, Xiao Li, Yongning Lu, Di Jin, Xiaomao Yin, Hao Jiang, Jing Huang, Huan Xiong, Fei Ye, Jia Jin, Yu Chen, Yiqian Xie, Zhifeng Chen, Hong Ding, Hao Zhang, Rongfeng Liu, Hualiang Jiang, Kaixian Chen, Zhiyi Yao, Cheng Luo, Yir Tags: Research Paper Source Type: research
Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3
Conclusions: These results demonstrate a novel pathway involving hsa_circ_0030042, eIF4A3, FOXO1, and beclin1; hence, modulating their levels may be a potential therapeutic strategy against CHD. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Fangpu Yu, Ya Zhang, Zunzhe Wang, Weigang Gong, Cheng Zhang Tags: Research Paper Source Type: research
Manganese-deposited iron oxide promotes tumor-responsive ferroptosis that synergizes the apoptosis of cisplatin
Conclusion: The Pt-FMO nanoplatform is designed to introduce mutual beneficial cascade reactions for promoting ferroptosis and apoptosis in combination with tumor MRI. The Pt-FMO system, which causes ferroptosis combined with apoptosis, can efficiently induce tumor cell death. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Junjie Cheng, Yang Zhu, Xin Xing, Jianmin Xiao, Hui Chen, Hongwei Zhang, Dan Wang, Yuanyuan Zhang, Guilong Zhang, Zhengyan Wu, Yangzhong Liu Tags: Research Paper Source Type: research
Sialylated immunoglobulin G: a promising diagnostic and therapeutic strategy for autoimmune diseases
Human immunoglobulin G (IgG), especially autoantibodies, has major implications for the diagnosis and management of a wide range of autoimmune diseases. However, some healthy individuals also have autoantibodies, while a portion of patients with autoimmune diseases test negative for serologic autoantibodies. Recent advances in glycomics have shown that IgG Fc N-glycosylations are more reliable diagnostic and monitoring biomarkers than total IgG autoantibodies in a wide variety of autoimmune diseases. Furthermore, these N-glycosylations of IgG Fc, particularly sialylation, have been reported to exert significant anti-inflam...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Danqi Li, Yuchen Lou, Yamin Zhang, Si Liu, Jun Li, Juan Tao Tags: Review Source Type: research
Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension
Conclusion: A comprehensive study on the importance of HMCN shell thickness in developing long-acting nano eye drops for the efficient management of glaucoma is proposed. The findings suggest a central role of nanobiomaterial structural engineering in developing the long-life eye drops for pharmacological treatment of intraocular diseases. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Li-Jyuan Luo, Duc Dung Nguyen, Jui-Yang Lai Tags: Research Paper Source Type: research
Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the leading causes of cancer-related death worldwide. Advanced HCC displays strong resistance to chemotherapy, and traditional chemotherapy drugs do not achieve satisfactory therapeutic efficacy. Sorafenib is an oral kinase inhibitor that inhibits tumor cell proliferation and angiogenesis and induces cancer cell apoptosis. It also improves the survival rates of patients with advanced liver cancer. However, due to its poor solubility, fast metabolism, and low bioavailability, clinical applications of sorafenib have been substantially restricte...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Fan-Hua Kong, Qi-Fa Ye, Xiong-Ying Miao, Xi Liu, Si-Qi Huang, Li Xiong, Yu Wen, Zi-Jian Zhang Tags: Review Source Type: research
Identification of the canonical and noncanonical role of miR-143/145 in estrogen-deficient bone loss
Conclusions: Our findings reveal a canonical and noncanonical role of miR-143/145 in controlling BMSCs pluripotency and unfold their dual effect on bone formation and bone resorption, suggesting miR-143/145 as promising therapeutic targets for treating estrogen-deficient bone loss. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Rongyao Xu, Xin Shen, Hanyu Xie, Hengguo Zhang, Dingshan Liu, Xin Chen, Yu Fu, Ping Zhang, Yi Yang, Jie Cheng, Hongbing Jiang Tags: Research Paper Source Type: research
STAT3 ameliorates cognitive deficits via regulation of NMDAR expression in an Alzheimer's disease animal model
Conclusions: Taken together, our study indicates that hTau accumulation impaired synaptic plasticity through STAT3 inactivation induced suppression of NMDARs expression, revealing a novel mechanism for hTau-associated synapse and memory deficits. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Hua-Li Wan, Xiao-Yue Hong, Zai-Hua Zhao, Ting Li, Bing-Ge Zhang, Qian Liu, Qun Wang, Shi Zhao, Jian-Zhi Wang, Xue-Feng Shen, Gong-Ping Liu Tags: Research Paper Source Type: research
Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice
Conclusion: Our results demonstrate that genetic fusion of a nanobody to ABD can significantly extend serum half-life, resulting in prolonged and homogenous tumor accumulation. Most importantly, as supported by the impressive anti-tumor efficacy observed after a single dose administration of 11A4-ABD-AF, our data reveal that monovalent internalizing ABD-fused nanobodies have potential for the development of highly effective NDCs. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Katerina T Xenaki, Bram Dorrestijn, Joey A Muns, Kevin Adamzek, Sofia Doulkeridou, HendrikJan Houthoff, Sabrina Oliveira, Paul MP van Bergen en Henegouwen Tags: Research Paper Source Type: research
