Vertebral-specific activation of the CX3CL1/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions
Conclusions: Our results indicated a unique feedback cycle between circulating NSCLC cells and VBMECs mediated by CX3CL1/ICAM-1 signaling, which is necessary for NSCLC spinal metastasis. This work provides a new perspective for underlying the mechanisms of NSCLC spinal metastasis and indicates potential novel targets for the prevention of NSCLC spinal metastasis. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Ketao Wang, Libo Jiang, Annan Hu, Chi Sun, Lei Zhou, Yiwei Huang, Qing Chen, Jian Dong, Xiaogang Zhou, Feng Zhang Tags: Research Paper Source Type: research
Thyroid hormone plus dual-specificity phosphatase-5 siRNA increases the number of cardiac muscle cells and improves left ventricular contractile function in chronic doxorubicin-injured hearts
Conclusion: RNA therapies are showing great potential. Importantly, a GMP compliant in vivo-jetPEI system for delivery of siRNA is already in use in humans, as is T3. Given these considerations, our findings provide a potentially highly translatable strategy for addressing doxorubicin cardiomyopathy, a currently untreatable condition. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Lin Tan, Nikolay Bogush, Emmen Naqvi, John W. Calvert, Robert M. Graham, W. Robert Taylor, Nawazish Naqvi, Ahsan Husain Tags: Research Paper Source Type: research
WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer
Conclusions: These data revealed that targeting WDR5 suppressed proliferation, enhanced apoptosis, chemosensitivity to cisplatin and immunotherapy in PCa. Therefore, our findings provide insight into OICR-9429 is a multi-potency and promising therapy drug, which improves the antitumor effect of cisplatin or immunotherapy in PCa. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Qianghua Zhou, Xu Chen, Haixia He, Shengmeng Peng, Yangjie Zhang, Jingtong Zhang, Liang Cheng, Sen Liu, Ming Huang, Ruihui Xie, Tianxin Lin, Jian Huang Tags: Research Paper Source Type: research
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux
Conclusions: SIRT2 ablation inhibits GSIS through blocking GKRP protein degradation and promoting ALDOA protein degradation, resulting in a decrease in glycolytic flux. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Feiye Zhou, Linlin Zhang, Kecheng Zhu, Mengyao Bai, Yuqing Zhang, Qin Zhu, Shushu Wang, Chunxiang Sheng, Miaomiao Yuan, Yun Liu, Jieli Lu, Li Shao, Xiao Wang, Libin Zhou Tags: Research Paper Source Type: research
The double-edged roles of ROS in cancer prevention and therapy
Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative metabolism and are associated with a number of human diseases. The reprogramming of redox metabolism induces abnormal accumulation of ROS in cancer cells. It has been widely accepted that ROS play opposite roles in tumor growth, metastasis and apoptosis according to their different distributions, concentrations and durations in specific subcellular structures. These double-edged roles in cancer progression include the ROS-dependent malignant transformation and the oxidative stress-induced cell death. In this review, we summarize the nota...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yawei Wang, Huan Qi, Yu Liu, Chao Duan, Xiaolong Liu, Tian Xia, Di Chen, Hai-long Piao, Hong-Xu Liu Tags: Review Source Type: research
In vivo fermentation production of humanized noncoding RNAs carrying payload miRNAs for targeted anticancer therapy
Conclusion: This novel ncRNA bioengineering technology and resulting recombinant ncRNAs are unique additions to conventional technologies and tools for basic research and drug development. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Peng-Cheng Li, Mei-Juan Tu, Pui Yan Ho, Neelu Batra, Michelle M.L. Tran, Jing-Xin Qiu, Theodore Wun, Primo N. Lara, Xiang Hu, Ai-Xi Yu, Ai-Ming Yu Tags: Research Paper Source Type: research
Recent progress of surface-enhanced Raman spectroscopy for subcellular compartment analysis
Organelles are involved in many cell life activities, and their metabolic or functional disorders are closely related to apoptosis, neurodegenerative diseases, cardiovascular diseases, and the development and metastasis of cancers. The explorations of subcellular structures, microenvironments, and their abnormal conditions are conducive to a deeper understanding of many pathological mechanisms, which are expected to achieve the early diagnosis and the effective therapy of diseases. Organelles are also the targeted locations of drugs, and they play significant roles in many targeting therapeutic strategies. Surface-enhanced...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yanting Shen, Jing Yue, Weiqing Xu, Shuping Xu Tags: Review Source Type: research
Requirement of G α i1 and G α i3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response
Conclusion: These findings highlight novel and essential roles for Gαi1/3 in regulating IL-4-induced signaling, macrophage M2 polarization and allergic asthma response. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jin-yu Bai, Ya Li, Guan-hua Xue, Ke-ran Li, Yu-Fan Zheng, Zhi-qing Zhang, Qin Jiang, Yuan-yuan Liu, Xiao-zhong Zhou, Cong Cao Tags: Research Paper Source Type: research
Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria
Antimicrobial resistance has been a global health challenge that threatens our ability to control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new drugs or alternatives to antibiotics, no new classes of antibiotic or their alternatives have been clinically approved in the last three decades. A combination of antibiotics and non-antibiotic compounds that could inhibit bacterial resistance determinants or enhance antibiotic activity offers a sustainable and effective strategy to confront multidrug-resistant bacteria. In this review, we provide a brief overview of the co-evolution of an...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yuan Liu, Ziwen Tong, Jingru Shi, Ruichao Li, Mathew Upton, Zhiqiang Wang Tags: Review Source Type: research
Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2
Conclusion: Our study established the role of PINT87aa as a novel biomarker and a key regulator of cellular senescence in HCC and identified PINT87aa as a potential therapeutic target for HCC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiaohong Xiang, Yunong Fu, Kun Zhao, Runchen Miao, Xing Zhang, Xiaohua Ma, Chang Liu, Nu Zhang, Kai Qu Tags: Research Paper Source Type: research
Candida albicans disorder is associated with gastric carcinogenesis
Conclusions: This study revealed GC-associated mycobiome imbalance characterized by an altered fungal composition and ecology and demonstrated that C. albicans can be a fungal biomarker for GC. With the significant increase of C. albicans in GC, the abundance of Fusicolla acetilerea, Arcopilus aureus, Fusicolla aquaeductuum were increased, while Candida glabrata, Aspergillus montevidensis, Saitozyma podzolica and Penicillium arenicola were obviously decreased. In addition, C. albicans may mediate GC by reducing the diversity and richness of fungi in the stomach, contributing to the pathogenesis of GC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Mengya Zhong, Yubo Xiong, Jiabao Zhao, Zhi Gao, Jingsong Ma, Zhengxin Wu, Yongxi Song, Xuehui Hong Tags: Research Paper Source Type: research
Single-cell transcriptome analysis of the heterogeneous effects of differential expression of tumor PD-L1 on responding TCR-T cells
Conclusion: Overall, though the effector functionality of TCR-T cells was suppressed by increased expression percentages of tumor PD-L1 in vitro, scRNA-seq profiles revealed that both the anti-inflammatory and pro-inflammatory responses were triggered by a higher expression of tumor PD-L1. This suggests that the sole blockade of tumor PD-L1 might inhibit not only the anti-inflammatory response but also the pro-inflammatory response in the complicated tumor microenvironment. Thus, the outcome of PD-L1 intervention may depend on the final balance among the highly dynamic and heterogeneous immune regulatory circuits. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Renpeng Ding, Shang Liu, Shanshan Wang, Huanyi Chen, Fei Wang, Qumiao Xu, Linnan Zhu, Xuan Dong, Ying Gu, Xiuqing Zhang, Cheng-Chi Chao, Qianqian Gao Tags: Research Paper Source Type: research
FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts
Conclusion: FOSL2/Wnt5a signaling plays an essential role in breast cancer angiogenesis in a VEGF-independent manner, and targeting the FOSL2/Wnt5a signaling axis in CAFs may offer a potential option for antiangiogenesis therapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xueying Wan, Shengdong Guan, Yixuan Hou, Yilu Qin, Huan Zeng, Liping Yang, Yina Qiao, Shuiqing Liu, Qiao Li, Ting Jin, Yuxiang Qiu, Manran Liu Tags: Research Paper Source Type: research
Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly
Conclusion: These findings offer substantial novel insights into the reproductive toxicity of DEHP exposure during murine germ cell cyst breakdown and primordial follicle formation. These results may enhance the understanding of DEHP exposure on reproductive health. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jun-Jie Wang, Yu Tian, Ming-Hao Li, Yan-Qin Feng, Li Kong, Fa-Li Zhang, Wei Shen Tags: Research Paper Source Type: research
Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis
Conclusions: Our study provides comprehensive insights into the global transcriptional signatures of autophagy-related genes and confirms the importance of autophagy homeostasis in SSC maintenance and normal spermatogenesis, opening new avenues for further dissecting the significance of the autophagy regulatory network in spermatogenesis as well as male infertility. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Mei Wang, Yanwen Xu, Yuncong Zhang, Yuhan Chen, Gang Chang, Geng An, Xinyan Yang, Caihong Zheng, Jiexiang Zhao, Zhaoting Liu, Dazhuang Wang, Kai Miao, Shuan Rao, Meng Dai, Dong Wang, Xiao-Yang Zhao Tags: Research Paper Source Type: research
