Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes
Conclusion: An HT-enriched diet significantly increased the number of Iba-1+ microglia/macrophages in the post-ischemic area, inducing higher expression of anti-inflammatory markers while no clear-cut effect was observed. Also, HT did not affect recovery of the cerebrovascular parameters, including ADC and CBF.Altogether, our data indicated that a prolonged dietary intervention with HT, as a single component of the Mediterranean diet, induces molecular changes that may improve stroke outcomes. Therefore, we support the use of the Mediterranean diet as a multicomponent therapy approach after stroke. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Cristina Barca, Maximilian Wiesmann, Jes ú s Calahorra, Lydia Wachsmuth, Christian D ö ring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Á ngeles Peinado, Eva Siles, Cornelius Faber, Michael Sch ä fers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Tags: Research Paper Source Type: research
Molecular imaging and biochemical response assessment after a single cycle of [225Ac]Ac-PSMA-617/[177Lu]Lu-PSMA-617 tandem therapy in mCRPC patients who have progressed on [177Lu]Lu-PSMA-617 monotherapy
Conclusion: Based on both assessment methods, [225Ac]Ac-PSMA-617/[177Lu]Lu-PSMA-617 tandem therapy is an effective treatment for the highly challenging cohort of patients with mCRPC who have progressed on [177Lu]Lu-PSMA-617 monotherapy. Molecular imaging response and biochemical PSA response were mostly concordant, though a considerable number of cases (29.4%) were discordant. Molecular imaging response reflecting the change in total viable tumour burden appears to be superior to PSA change in estimating survival outcome after tandem therapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Florian Rosar, Fabian Hau, Mark Bartholom ä , Stephan Maus, Tobias Stemler, Johannes Linxweiler, Samer Ezziddin, Fadi Khreish Tags: Research Paper Source Type: research
miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene
Conclusion: Collectively our findings reveal that oral administration of GDNP to HFD mice improves host glucose tolerance and insulin response via regulating AhR expression by GDNP induced miR-375 and VAMP7. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Anil Kumar, Yi Ren, Kumaran Sundaram, Jingyao Mu, Mukesh K Sriwastva, Gerald W Dryden, Chao Lei, Lifeng Zhang, Jun Yan, Xiang Zhang, Juw Won Park, Michael L Merchant, Yun Teng, Huang-Ge Zhang Tags: Research Paper Source Type: research
Electroacupuncture ameliorates intestinal inflammation by activating α 7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus
Conclusions: The present study revealed that EA of hindlimb regions inhibited the expression of GABAA receptor in DMV neurons, whose excited vagal nerve, in turn suppressed IM-induced inflammation via activation of α7nAChR-mediated JAK2/STAT3 signaling pathway. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Na-Na Yang, Jing-Wen Yang, Yang Ye, Jin Huang, Lu Wang, Yu Wang, Xin-Tong Su, Ying Lin, Fang-Ting Yu, Si-Ming Ma, Ling-Yu Qi, Lu-Lu Lin, Li-Qiong Wang, Guang-Xia Shi, Hong-Ping Li, Cun-Zhi Liu Tags: Research Paper Source Type: research
Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS)
Conclusion: Our results show that this method can be used to improve the accuracy and robustness of in vivo Raman/SERS biomedical application, aiding the process of clinical translation of these technologies. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Pietro Strobbia, Vanessa Cupil-Garcia, Bridget M. Crawford, Andrew M. Fales, T. Joshua Pfefer, Yang Liu, Martin Maiwald, Bernd Sumpf, Tuan Vo-Dinh Tags: Research Paper Source Type: research
MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease
In this study, we discovered that microglia-specific miR-146a overexpression reduced cognitive deficits in learning and memory, attenuated neuroinflammation, reduced Aβ levels, ameliorated plaque-associated neuritic pathology, and prevented neuronal loss in APP/PS1 transgenic mice. In addition, we found that miR-146a switched the microglial phenotype, reduced pro-inflammatory cytokines and enhanced phagocytic function to protect neurons in vitro and in vivo. Moreover, transcriptional analysis confirmed that miR-146a opposed the pathological process of AD mainly through neuroinflammation-related pathways. In summary, o...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chunmei Liang, Ting Zou, Miaoping Zhang, Weihao Fan, Tianzhen Zhang, Yuling Jiang, Yujie Cai, Feng Chen, Xiongjin Chen, Yuanhong Sun, Bin Zhao, Yan Wang, Lili Cui Tags: Research Paper Source Type: research
MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer
Conclusion: Our results suggest that phospho-MARCKS is a novel NF-kB activator in smoke-mediated lung cancer progression and provide a promising molecular model for developing new anticancer strategies. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jun Liu, Szu-Jung Chen, Ssu-Wei Hsu, Jun Zhang, Ji-Min Li, David C. Yang, Shenwen Gu, Kent E. Pinkerton, Ching-Hsien Chen Tags: Research Paper Source Type: research
Balancing the stability and drug activation in adaptive nanoparticles potentiates chemotherapy in multidrug-resistant cancer
Conclusion: Collectively, our approach enables more effective and less toxic delivery of the cabazitaxel drug, which could be a new generalizable strategy for re-engineering other toxic and water-insoluble therapeutics. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jianqin Wan, Lingling Huang, Jiangting Cheng, Huangfu Qi, Jiahui Jin, Hangxiang Wang Tags: Research Paper Source Type: research
Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer
Conclusion: Pectin facilitated the anti-PD-1 mAb efficacy in CRC via regulating the T cell infiltration in the tumor microenvironment, which was potentially mediated by the metabolite butyrate. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Shi-Long Zhang, Yu-Qin Mao, Zheng-Yan Zhang, Zhan-Ming Li, Chao-Yue Kong, Hui-Ling Chen, Pei-Ran Cai, Bing Han, Tao Ye, Li-Shun Wang Tags: Research Paper Source Type: research
Redox-sensitive carrier-free nanoparticles self-assembled by disulfide-linked paclitaxel-tetramethylpyrazine conjugate for combination cancer chemotherapy
Conclusions: These in vitro and in vivo results provide clear evidence that this redox-responsive carrier-free nanosystem with intrinsic amphiphilicity has great potential for combination cancer chemotherapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Liang Zou, Xiaowei Liu, Jingjing Li, Wei Li, Lele Zhang, Chaomei Fu, Jinming Zhang, Zhongwei Gu Tags: Research Paper Source Type: research
SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF- κ B signaling
Conclusion: Our results indicate that SARM1-mediated prodegenerative pathway and neuroinflammation promotes the pathological progress of SCI and anti-SARM1 therapeutics are viable and promising approaches for preserving neuronal function after SCI. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Huitao Liu, Jingjing Zhang, Xingxing Xu, Sheng Lu, Danlu Yang, Changnan Xie, Mengxian Jia, Wenbin Zhang, Lingting Jin, Xiwu Wang, Xiya Shen, Fayi Li, Wangfei Wang, Xiaomei Bao, Sijia Li, Minyu Zhu, Wei Wang, Ying Wang, Zhihui Huang, Honglin Teng Tags: Research Paper Source Type: research
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis
Conclusions: The present findings uncovered a novel pro-EndMT mechanism during the pathogenesis of diabetic cardiac fibrosis via the upregulation of KLK8, and may contribute to the development of future KLK8-based therapeutic strategies for diabetic cardiomyopathy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jian-Kui Du, Qing Yu, Yu-Jian Liu, Shu-Fang Du, Li-Yang Huang, Dan-Hong Xu, Xin Ni, Xiao-Yan Zhu Tags: Research Paper Source Type: research
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma
Conclusions: Our findings provided evidence that loss of SPTBN1 in HCC cells increases p65 protein stability via the inhibition of SOCS1 and enhances NF-κB activation, stimulating the release of inflammatory cytokines, which are critical molecular mechanisms for the loss of SPTBN1-induced liver cancer formation. Reduced SPTBN1 and SOCS1 predict poor outcome in HCC patients. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Ling Lin, Shuyi Chen, Hua Wang, Bin Gao, Bhaskar Kallakury, Krithika Bhuvaneshwar, Katherine Cahn, Yuriy Gusev, Xue Wang, Yunan Wu, John L. Marshall, Xiuling Zhi, Aiwu Ruth He Tags: Research Paper Source Type: research
Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production
Conclusions: Our findings identify the dual anti-inflammatory and pro-resolving actions of dabigatran, through promoting sFgl2-triggered RvD5n-3 DPA production, which has important implications for promoting tissue homeostasis of sepsis. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Juan Lei, Yu Zhou, Huakan Zhao, Yu Chen, Guifang Yan, Lei Wu, Yanquan Xu, Jiangang Zhang, Xiao Zhang, Jingchun Wang, Dingshan Li, Yongsheng Li Tags: Research Paper Source Type: research
Thymosin β 4 released from functionalized self-assembling peptide activates epicardium and enhances repair of infarcted myocardium
Conclusions: These results demonstrate that sustained release of Tβ4 from the functionalized SAP can activate the epicardium and effectively enhance the repair of infarcted myocardium. We believe the delivery of SAP-Tβ4 may be a promising strategy for MI therapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yong-li Wang, Shu-na Yu, Hao-ran Shen, Hai-jie Wang, Xue-ping Wu, Qiang-li Wang, Bin Zhou, Yu-zhen Tan Tags: Research Paper Source Type: research
