Comparative effectiveness and cost-effectiveness of treat-to-target versus benefit-based tailored treatment of type 2 diabetes in low-income and middle-income countries: a modelling analysis
Publication date: Available online 4 October 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Sanjay Basu, Vishnu Shankar, John S Yudkin Background Optimal prescription of blood pressure, lipid, and glycaemic control treatments for adults with type 2 diabetes remains unclear. We aimed to compare the effectiveness and cost-effectiveness of two treatment approaches for diabetes management in five low-income and middle-income countries. Methods We developed a microsimulation model to compare a treat-to-target (TTT) strategy, aiming to achieve target levels of biomarkers (blood pressure <130/80 mm Hg,...
Source: The Lancet Diabetes and Endocrinology - October 6, 2016 Category: Endocrinology Source Type: research

Effectiveness of activity trackers with and without incentives to increase physical activity (TRIPPA): a randomised controlled trial
Publication date: Available online 4 October 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Eric A Finkelstein, Benjamin A Haaland, Marcel Bilger, Aarti Sahasranaman, Robert A Sloan, Ei Ei Khaing Nang, Kelly R Evenson Background Despite the increasing popularity of activity trackers, little evidence exists that they can improve health outcomes. We aimed to investigate whether use of activity trackers, alone or in combination with cash incentives or charitable donations, lead to increases in physical activity and improvements in health outcomes. Methods In this randomised controlled trial, employees fro...
Source: The Lancet Diabetes and Endocrinology - October 6, 2016 Category: Endocrinology Source Type: research

Growing a billion dollar industry
Publication date: Available online 5 October 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Fiona Mitchell (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - October 6, 2016 Category: Endocrinology Source Type: research

Pablo Perel: leading improvements in global cardiovascular health
Publication date: Available online 5 October 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Fiona Mitchell (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - October 6, 2016 Category: Endocrinology Source Type: research

Critical fat studies and obesity in Canada
Publication date: Available online 5 October 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Arya M Sharma (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - October 6, 2016 Category: Endocrinology Source Type: research

Childhood obesity: changing perceptions
Publication date: Available online 5 October 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Fiona Mitchell (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - October 6, 2016 Category: Endocrinology Source Type: research

Correction to Lancet Diabetes Endocrinol 2016; 4: 812 –14
Publication date: Available online 28 September 2016 Source:The Lancet Diabetes & Endocrinology (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 29, 2016 Category: Endocrinology Source Type: research

Association between exogenous testosterone and cardiovascular events: an overview of systematic reviews
Publication date: Available online 23 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Oluwadamilola Onasanya, Geetha Iyer, Eleanor Lucas, Dora Lin, Sonal Singh, G Caleb Alexander Given the conflicting evidence regarding the association between exogenous testosterone and cardiovascular events, we systematically assessed published systematic reviews for evidence of the association between exogenous testosterone and cardiovascular events. We searched PubMed, MEDLINE, Embase, Cochrane Collaboration Clinical Trials, ClinicalTrials.gov, and the US Food and Drug Administration website for systematic ...
Source: The Lancet Diabetes and Endocrinology - September 24, 2016 Category: Endocrinology Source Type: research

Correction to Lancet Diabetes Endocrinol 2016; 4: 756 –65
Publication date: October 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 10 (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 21, 2016 Category: Endocrinology Source Type: research

Research digest: weight loss to prevent and treat diabetes
Publication date: October 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 10 Author(s): Naveed Sattar, Jennifer Logue, David Preiss (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 21, 2016 Category: Endocrinology Source Type: research

Strengthening of information systems and research to tackle HIV and non-communicable diseases
Publication date: October 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 10 Author(s): Pratik Khanal, Anu Khanal (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 21, 2016 Category: Endocrinology Source Type: research

SGLT2 inhibitors: β blockers for the kidney?
Publication date: October 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 10 Author(s): Richard E Gilbert (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 21, 2016 Category: Endocrinology Source Type: research

Renoprotection in LEADER and EMPA-REG OUTCOME
Publication date: October 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 10 Author(s): Marcel H A Muskiet, Lennart Tonneijck, Erik J M van Bommel, Mark M Smits, Daniël H van Raalte (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 21, 2016 Category: Endocrinology Source Type: research

Building better health
Publication date: October 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 10 Author(s): The Lancet Diabetes & Endocrinology (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 21, 2016 Category: Endocrinology Source Type: research

GLP-1 receptor agonists and SGLT2 inhibitors: a couple at last?
Publication date: Available online 16 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Michael A Nauck, Juris J Meier (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 17, 2016 Category: Endocrinology Source Type: research

Exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy (DURATION-8): a 28 week, multicentre, double-blind, phase 3, randomised controlled trial
Publication date: Available online 16 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Juan P Frías, Cristian Guja, Elise Hardy, Azazuddin Ahmed, Fang Dong, Peter Öhman, Serge A Jabbour Background Glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce glycaemia and weight, and improve cardiovascular risk factors via different mechanisms. We aimed to compare the efficacy and safety of co-initiation of the GLP-1 receptor agonist exenatide and the SGLT2 inhibitor dapagliflozin with exenatide or dapagliflozin alone in patients wit...
Source: The Lancet Diabetes and Endocrinology - September 17, 2016 Category: Endocrinology Source Type: research

IN CONTROL of type 1 diabetes, despite hypoglycaemia unawareness
Publication date: Available online 15 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Joseph El Youssef (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 16, 2016 Category: Endocrinology Source Type: research

Continuous glucose monitoring for patients with type 1 diabetes and impaired awareness of hypoglycaemia (IN CONTROL): a randomised, open-label, crossover trial
Publication date: Available online 15 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Cornelis A J van Beers, J Hans DeVries, Susanne J Kleijer, Mark M Smits, Petronella H Geelhoed-Duijvestijn, Mark H H Kramer, Michaela Diamant, Frank J Snoek, Erik H Serné Background Patients with type 1 diabetes who have impaired awareness of hypoglycaemia have a three to six times increased risk of severe hypoglycaemia. We aimed to assess whether continuous glucose monitoring (CGM) improves glycaemia and prevents severe hypoglycaemia compared with self-monitoring of blood glucose (SMBG) in this high-r...
Source: The Lancet Diabetes and Endocrinology - September 16, 2016 Category: Endocrinology Source Type: research

Clinical relevance of the bile acid receptor TGR5 in metabolism
Publication date: Available online 14 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): F Samuel van Nierop, Matthijs J Scheltema, Hannah M Eggink, Thijs W Pols, David P Sonne, Filip K Knop, Maarten R Soeters The bile acid receptor TGR5 (also known as GPBAR1) is a promising target for the development of pharmacological interventions in metabolic diseases, including type 2 diabetes, obesity, and non-alcoholic steatohepatitis. TGR5 is expressed in many metabolically active tissues, but complex enterohepatic bile acid cycling limits the exposure of some of these tissues to the receptor ligand. Prof...
Source: The Lancet Diabetes and Endocrinology - September 15, 2016 Category: Endocrinology Source Type: research

Mich èle Ramsay: working collaboratively to improve African health
Publication date: Available online 13 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Fiona Mitchell (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 14, 2016 Category: Endocrinology Source Type: research

Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis
Publication date: Available online 3 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Natriuretic Peptides Studies Collaboration Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present by predicting heart failure and enhancing coronary heart disease and stroke risk assessment. Methods In this individual-participant-data meta-analysis, we generated and harmoni...
Source: The Lancet Diabetes and Endocrinology - September 3, 2016 Category: Endocrinology Source Type: research

Cardiac natriuretic peptides in plasma: from prediction to precision medicine
Publication date: Available online 3 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Jens P Goetze, Nora E Zois (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - September 3, 2016 Category: Endocrinology Source Type: research

Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial
We examined whether the incidence of cardiovascular disease in Look AHEAD varied by changes in weight or fitness. Methods Look AHEAD was a randomised clinical trial done at 16 clinical sites in the USA, recruiting patients from Aug 22, 2001, to April 30, 2004. In the trial, 5145 overweight or obese adults aged 45–76 years with type 2 diabetes were assigned (1:1) to an intensive lifestyle intervention or diabetes support and education. In this observational, post-hoc analysis, we examined the association of magnitude of weight loss and fitness change over the first year with incidence of cardiovascular disease. The pr...
Source: The Lancet Diabetes and Endocrinology - August 31, 2016 Category: Endocrinology Source Type: research

Lifestyle changes and cardiovascular risk reduction in diabetes
Publication date: Available online 30 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Matti Uusitupa (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 31, 2016 Category: Endocrinology Source Type: research

Liberating non-communicable disease data
Publication date: Available online 25 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Peter H Bennett, Dianna J Magliano, K George Alberti, Paul Zimmet (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 26, 2016 Category: Endocrinology Source Type: research

Papillary thyroid microcarcinoma: time to shift from surgery to active surveillance?
Publication date: Available online 20 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Sophie Leboulleux, R Michael Tuttle, Furio Pacini, Martin Schlumberger The incidence of differentiated thyroid cancer is increasing greatly in high-income countries. Roughly 50% of this increase is attributable to the identification of intrathyroidal papillary thyroid microcarcinomas. Since mortality associated with these tumours remains low and stable, the increasing diagnosis has led to concerns about overdiagnosis and overtreatment. Management of papillary thyroid microcarcinomas should take into account the ...
Source: The Lancet Diabetes and Endocrinology - August 21, 2016 Category: Endocrinology Source Type: research

Use and misuse of hormones in sport
Publication date: Available online 16 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Peter H Sonksen, David Cowan, Richard I G Holt (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 18, 2016 Category: Endocrinology Source Type: research

Correction to Lancet Diabetes Endocrinol 2016; 4: 733 –34
Publication date: September 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 9 (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 18, 2016 Category: Endocrinology Source Type: research

Country in focus: Gulf region states face major health challenges from obesity and diabetes
Publication date: September 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 9 Author(s): Talha Khan Burki (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 18, 2016 Category: Endocrinology Source Type: research

Oral glucose tolerance testing and cardiovascular disease
Publication date: September 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 9 Author(s): Lars Rydén, Gyberg Viveca, Oliver Schnell, Tuomilehto Jaakko (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 18, 2016 Category: Endocrinology Source Type: research

Moving forward with research and care for diabetic foot disease
Publication date: September 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Issue 9 Author(s): The Lancet Diabetes & Endocrinology (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 18, 2016 Category: Endocrinology Source Type: research

Burden of diabetes in Iran: how will it be affected by lifting of the economic sanctions?
Publication date: Available online 12 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Bagher Larijani (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 13, 2016 Category: Endocrinology Source Type: research

Incentives in workplace wellness programmes
Publication date: Available online 8 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Justin S White (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 9, 2016 Category: Endocrinology Source Type: research

Hyperandrogenism rule no longer in play at Rio Olympics
Publication date: Available online 5 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Talha Khan Burki (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 6, 2016 Category: Endocrinology Source Type: research

The global diabetes epidemic: what does it mean for infectious diseases in tropical countries?
Publication date: Available online 4 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Reinout van Crevel, Steven van de Vijver, David A J Moore Tropical countries are experiencing a substantial rise in type 2 diabetes, which is often undiagnosed or poorly controlled. Since diabetes is a risk factor for many infectious diseases, this increase probably adds to the large infectious disease burden in tropical countries. We reviewed the literature to investigate the interface between diabetes and infections in tropical countries, including the WHO-defined neglected tropical diseases. Although solid dat...
Source: The Lancet Diabetes and Endocrinology - August 5, 2016 Category: Endocrinology Source Type: research

Correction to Lancet Diabetes Endocrinol 2016; 4: 647
Publication date: Available online 3 August 2016 Source:The Lancet Diabetes & Endocrinology (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 4, 2016 Category: Endocrinology Source Type: research

Minority groups and the artificial pancreas: who is (not) in line?
Publication date: Available online 1 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Lauren Huyett, Eyal Dassau, Jordan E Pinsker, Francis J Doyle, David Kerr (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 3, 2016 Category: Endocrinology Source Type: research

De-evolution of diagnostic testing for adrenal insufficiency
Publication date: Available online 1 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Gregory A Kline, Daniel T Holmes (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - August 3, 2016 Category: Endocrinology Source Type: research

Diabetic macular oedema
Publication date: Available online 3 August 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Gavin S Tan, Ning Cheung, Rafael Simó, Gemmy C M Cheung, Tien Yin Wong Diabetic macular oedema, characterised by exudative fluid accumulation in the macula, is the most common form of sight-threatening retinopathy in people with diabetes. It affects one in 15 people with diabetes resulting in more than 20 million cases worldwide. Few epidemiological studies have been done to specifically investigate risk factors for diabetic macular oedema, although poor glycaemic and blood pressure control are associated ...
Source: The Lancet Diabetes and Endocrinology - August 3, 2016 Category: Endocrinology Source Type: research

Research digest: NAFLD in the spotlight
Publication date: Available online 30 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): David Preiss, Naveed Sattar (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - July 30, 2016 Category: Endocrinology Source Type: research

Knowing what we do not know: statin therapy in advanced chronic kidney disease
Publication date: Available online 29 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Muh Geot Wong, Vlado Perkovic (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - July 29, 2016 Category: Endocrinology Source Type: research

Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials
Publication date: Available online 29 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Cholesterol Treatment Trialists' (CTT) Collaboration Background Statin therapy is effective for the prevention of coronary heart disease and stroke in patients with mild-to-moderate chronic kidney disease, but its effects in individuals with more advanced disease, particularly those undergoing dialysis, are uncertain. Methods We did a meta-analysis of individual participant data from 28 trials (n=183 419), examining effects of statin-based therapy on major vascular events (major coronary event [non-fatal myoca...
Source: The Lancet Diabetes and Endocrinology - July 29, 2016 Category: Endocrinology Source Type: research

An internet-based intervention with brief nurse support to manage obesity in primary care (POWeR+): a pragmatic, parallel-group, randomised controlled trial
Publication date: Available online 26 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Paul Little, Beth Stuart, FD Richard Hobbs, Jo Kelly, Emily R Smith, Katherine J Bradbury, Stephanie Hughes, Peter W F Smith, Michael V Moore, Mike E J Lean, Barrie M Margetts, Chris D Byrne, Simon Griffin, Mina Davoudianfar, Julie Hooper, Guiqing Yao, Shihua Zhu, James Raftery, Lucy Yardley Background The obesity epidemic has major public health consequences. Expert dietetic and behavioural counselling with intensive follow-up is effective, but resource requirements severely restrict widesprea...
Source: The Lancet Diabetes and Endocrinology - July 28, 2016 Category: Endocrinology Source Type: research

Splitting atoms: the Endocrine Society guideline for the management of primary aldosteronism
Publication date: Available online 26 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Morris J Brown, William M Drake (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - July 28, 2016 Category: Endocrinology Source Type: research

Monogenic autoimmune diseases of the endocrine system
Publication date: Available online 26 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Matthew B Johnson, Andrew T Hattersley, Sarah E Flanagan The most common endocrine diseases, type 1 diabetes, hyperthyroidism, and hypothyroidism, are the result of autoimmunity. Clustering of autoimmune endocrinopathies can result from polygenic predisposition, or more rarely, may present as part of a wider syndrome due to a mutation within one of seven genes. These monogenic autoimmune diseases show highly variable phenotypes both within and between families with the same mutations. The average age of onset ...
Source: The Lancet Diabetes and Endocrinology - July 28, 2016 Category: Endocrinology Source Type: research

The POWeR of looking into the black box
Publication date: Available online 26 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Emily Brindal (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - July 28, 2016 Category: Endocrinology Source Type: research

Type 1 diabetes: the need for culture-appropriate nutritional information for carbohydrate counting
Publication date: Available online 25 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Hamza Nasir, Sumana Narasimhan (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - July 27, 2016 Category: Endocrinology Source Type: research

Lipoprotein(a) and familial hypercholesterolaemia
Publication date: Available online 23 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Leopoldo Pérez de Isla, Adriana Saltijeral Cerezo, Rodrigo Alonso, Pedro Mata (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - July 24, 2016 Category: Endocrinology Source Type: research

Lipoprotein(a) and familial hypercholesterolaemia – Authors' reply
Publication date: Available online 23 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Anne Langsted, Pia R Kamstrup, Marianne Benn, Anne Tybjærg-Hansen, Børge G Nordestgaard (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - July 24, 2016 Category: Endocrinology Source Type: research

Collaborative funding for NCDs —a model of research funding
Publication date: Available online 23 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Justine Davies (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - July 24, 2016 Category: Endocrinology Source Type: research